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Specialty: Biochemistry
Source: Amino Acids
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Total 24 results found since Jan 2013.
Interaction of exercise training with taurine attenuates infarct size and cardiac dysfunction via Akt-Foxo3a-Caspase-8 signaling pathway
Amino Acids. 2023 May 18. doi: 10.1007/s00726-023-03275-4. Online ahead of print.ABSTRACTThis research aimed to investigate the synergistic protective effect of exercise training and taurine on Akt-Foxo3a-Caspase-8 signaling related to infarct size and cardiac dysfunction. Therefore, 25 male Wistar rats with MI were divided into five groups: sham (Sh), control-MI(C-MI), exercise training-MI(Exe-MI), taurine supplementation-MI(Supp-MI), and exercise training + taurine-MI(Exe + Supp-MI). The taurine groups were given a 200 mg/kg/day dose of taurine by drinking water. Exercise training was conducted for 8 weeks (5 days/week),...
Source: Amino Acids - May 19, 2023 Category: Biochemistry Authors: Abolfazl Razzaghi Siroos Choobineh Abbasali Gaeini Rahman Soori Source Type: research
A search for acrolein scavengers among food components
In this study, we tried to identify food components which decrease acrolein toxicity. We found that 2-furanmethanethiol, cysteine methyl and ethyl esters, alliin, lysine and taurine decreased acrolein toxicity. These compounds neutralized acrolein by direct interaction. However, the interaction between acrolein and taurine was not so strong. Approximately 30 mM taurine was necessary to interact with 10 μM acrolein, and 2 g/kg taurine was necessary to decrease the size of mouse brain infarction. Taurine also slightly increased polyamine contents, which are involved in decrease in the acrolein toxicity. Mitochondrial potent...
Source: Amino Acids - February 8, 2023 Category: Biochemistry Authors: Takeshi Uemura Masashi Uchida Mizuho Nakamura Momo Shimekake Akihiko Sakamoto Yusuke Terui Kyohei Higashi Itsuko Ishii Keiko Kashiwagi Kazuei Igarashi Source Type: research
Accurately quantified plasma free glycine concentration as a biomarker in patients with acute ischemic stroke
Amino Acids. 2023 Jan 25. doi: 10.1007/s00726-023-03236-x. Online ahead of print.ABSTRACTWe developed a hollow fiber centrifugal ultrafiltration (HFCF-UF) method to study the change of plasma levels of free glycine (Gly) in patients with acute ischemic stroke (AIS). Twenty-four patients with AIS confirmed by diffusion-weighted imaging (DWI) were enrolled. During the study period, the patients did not receive any supplemental amino acids therapy that could affect the obtained results. Our results showed that although AIS patients adopted different methods of treatment (thrombolytic and non-thrombolytic), the clinical NIHSS ...
Source: Amino Acids - January 25, 2023 Category: Biochemistry Authors: Huan Wang Xiaoyu Ni Weichong Dong Weiman Qin Lei Xu Ye Jiang Source Type: research
Functional roles of polyamines and their metabolite acrolein in eukaryotic cells
Amino Acids. 2021 Sep 21. doi: 10.1007/s00726-021-03073-w. Online ahead of print.ABSTRACTAmong low molecular weight substances, polyamines (spermidine, spermine and their precursor putrescine) are present in eukaryotic cells at the mM level together with ATP and glutathione. It is expected therefore that polyamines play important roles in cell proliferation and viability. Polyamines mainly exist as a polyamine-RNA complex and regulate protein synthesis. It was found that polyamines enhance translation from inefficient mRNAs. The detailed mechanisms of polyamine stimulation of specific kinds of protein syntheses and the phy...
Source: Amino Acids - September 21, 2021 Category: Biochemistry Authors: Kazuei Igarashi Keiko Kashiwagi Source Type: research
Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK-STROKE)
Amino Acids. 2021 Mar 31. doi: 10.1007/s00726-021-02969-x. Online ahead of print.ABSTRACTTrimethyllysine (TML) is involved in the generation of the pro-atherogenic metabolite trimethylamine-N-oxide (TMAO) by gut microbiota. In clinical studies, elevated TML levels predicted major adverse cardiovascular events (MACE) in patients with acute or stable coronary artery disease (CAD). In contrast to cardiovascular patients, the role of TML in patients with acute cerebral ischemia is unknown. Here, we evaluated circulating TML levels in 374 stroke patients from the prospective biomarkers in stroke (MARK-STROKE) study. Compared wi...
Source: Amino Acids - March 31, 2021 Category: Biochemistry Authors: Edzard Schwedhelm Mirjam von Lucadou Sven Peine Susanne Lezius G ötz Thomalla Rainer B öger Christian Gerloff Chi-Un Choe Source Type: research
