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Primary astrocytic mitochondrial transplantation ameliorates ischemic stroke
In this study, we observed that treatment with mitochondria isolated from rat primary astrocytes enhanced cell viability and ameliorated hydrogen peroxide-damaged neurons. Interestingly, isolated astrocytic mitochondria increased the number of cells under damaged neuronal conditions, but not under normal conditions, although the mitochondrial transfer efficiency did not differ between the two conditions. This effect was also observed after transplanting astrocytic mitochondria in a rat middle cerebral artery occlusion model. These findings suggest that mitochondria transfer therapy can be used to treat acute ischemic strok...
Source: BMB Reports - October 4, 2022 Category: Biochemistry Authors: Eun-Hye Lee Minkyung Kim Seung Hwan Kim Chun-Hyung Kim Minhyung Lee Chang-Hwan Park Source Type: research

Erratum to: Stem cell-derived extracellular vesicle therapy for acute brain insults and neurodegenerative diseases
This article was republished on 30 April 2022, to correct the online version of the article which displayed an incorrect References. After online publication of this article, the authors noticed an error in the missing reference section for the page 21 and the Figure 1. The correct statement of this article should have read as below. 1. Our pre-specified biomarker sub-study showed that circulating EVs were markedly increased immediately after intravenous injection of MSCs (10). In this study, the number of the circulating EVs varied among patients after the application of the same dose of MSCs, and was associated with moto...
Source: BMB Reports - April 27, 2022 Category: Biochemistry Authors: Oh Young Bang Ji-Eun Kim Source Type: research

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