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Specialty: Biochemistry
Source: Biochimica et Biophysica Acta
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Total 36 results found since Jan 2013.
Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats
This study aimed to investigate the roles of melatonin on pyroptosis, necroptosis, and pro-inflammatory pathways occurring in the I/R brain of obese rats. Male Wistar rats were given a high-fat diet for 16 weeks to induce the obese condition, and then were divided into 4 groups: Sham-operated, I/R treated with vehicle, I/R treated with melatonin (10 mg/kg), and I/R treated with glycyrrhizic acid (10 mg/kg). All drugs were administered via intraperitoneal injection at the onset of reperfusion. The development of neurological deficits, cerebral infarction, histological changes, neuronal death, and glial cell hyperactivation ...
Source: Biochimica et Biophysica Acta - June 11, 2023 Category: Biochemistry Authors: Nuttapong Yawoot Jirakhamon Sengking Piyarat Govitrapong Chainarong Tocharus Jiraporn Tocharus Source Type: research
Inosine attenuates post-stroke neuroinflammation by modulating inflammasome mediated microglial activation and polarization
Biochim Biophys Acta Mol Basis Dis. 2023 Jun 5:166771. doi: 10.1016/j.bbadis.2023.166771. Online ahead of print.ABSTRACTTo date, various agents and molecules have been developed to treat post-stroke neuroinflammation; however, none of them are clinically successful. Post-stroke neuroinflammation is primarily attributed to microglial polarization as the generation of inflammasome complexes shifts microglia to their M1 phenotype and regulate the downstream cascade. Inosine, an adenosine derivative reported to maintain cellular energy homeostasis in stressed condition. Although, the exact mechanism is still unexplored, variou...
Source: Biochimica et Biophysica Acta - June 7, 2023 Category: Biochemistry Authors: Aishika Datta Pramod Suthar Deepaneeta Sarmah Poonam Jadhav Jinagna Shah Mounika Katamneni Nikhil Bhosale Vishal Gupta Mariya Bohra Falguni Baidya Nikita Rana Bijoyani Ghosh Harpreet Kaur Anupom Borah Rajeshwari Rathod Pinaki Sengupta Pallab Bhattacharya Source Type: research
Kinases in cerebral cavernous malformations: Pathogenesis and therapeutic targets
Biochim Biophys Acta Mol Cell Res. 2023 May 18:119488. doi: 10.1016/j.bbamcr.2023.119488. Online ahead of print.ABSTRACTCerebral cavernous malformations (CCMs) are low-flow, hemorrhagic vascular lesions of the central nervous system of genetic origin, which can cause stroke-like symptoms and seizures. From the identification of CCM1, CCM2 and CCM3 as genes related to disease progression, molecular and cellular mechanisms for CCM pathogenesis have been established and the search for potential drugs to target CCM has begun. Broadly speaking, kinases are the major group signaling in CCM pathogenesis. These include the MEKK3/M...
Source: Biochimica et Biophysica Acta - May 20, 2023 Category: Biochemistry Authors: Chunxiao Qi Richard Sean Bujaroski Jonathan Baell Xiangjian Zheng Source Type: research
Biomechanical regulation of planar cell polarity in endothelial cells
This study provides new ideas and therapeutic targets for the treatment of endothelial PCP-related diseases.PMID:35850177 | DOI:10.1016/j.bbadis.2022.166495
Source: Biochimica et Biophysica Acta - July 19, 2022 Category: Biochemistry Authors: Caihong Wang Kai Qu Jing Wang Rui Qin Bingyi Li Juhui Qiu Guixue Wang Source Type: research
Protein-based HDL subspecies: Rationale and association with cardiovascular disease, diabetes, stroke, and dementia
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 May 20:159182. doi: 10.1016/j.bbalip.2022.159182. Online ahead of print.ABSTRACTHDL-cholesterol is associated with reduced risk of cardiovascular disease, and is used in clinical practice for risk stratification. HDL is composed of many protein-defined subspecies that each comprises just a few percent of the total, some associated with lower and some with higher risk of CVD. HDL that contains apoC3 and apoE are subspecies that have opposing actions on HDL reverse cholesterol transport and opposing associations with risk of future CVD, apoC3 adverse and apoE beneficial. In add...
Source: Biochimica et Biophysica Acta - May 23, 2022 Category: Biochemistry Authors: F M Sacks J D Furtado M K Jensen Source Type: research
BMAL1 modulates smooth muscle cells phenotypic switch towards fibroblast-like cells and stabilizes atherosclerotic plaques by upregulating YAP1
Biochim Biophys Acta Mol Basis Dis. 2022 May 19:166450. doi: 10.1016/j.bbadis.2022.166450. Online ahead of print.ABSTRACTBACKGROUND: Ischemic heart diseases and ischemic stroke are closely related to circadian clock and unstable atherosclerotic plaques. Vascular smooth muscle cells (VSMCs) can stabilize or destabilize an atherosclerotic lesion through phenotypic switch. BMAL1 is not only an indispensable core component in circadian clock but also an important regulator in atherosclerosis and VSMCs proliferation. However, little is known about the modulation mechanisms of BMAL1 in VSMCs phenotypic switch and atherosclerotic...
Source: Biochimica et Biophysica Acta - May 22, 2022 Category: Biochemistry Authors: Yang Shen Li-Rong Xu Dong Yan Min Zhou Tong-Lei Han Chao Lu Xiao Tang Chang-Po Lin Rui-Zhe Qian Da-Qiao Guo Source Type: research
Molecular mechanisms governing aquaporin relocalisation
Biochim Biophys Acta Biomembr. 2021 Dec 29:183853. doi: 10.1016/j.bbamem.2021.183853. Online ahead of print.ABSTRACTThe aquaporins (AQPs) form a family of integral membrane proteins that facilitate the movement of water across biological membrane by osmosis, as well as facilitating the diffusion of small polar solutes. AQPs have been recognised as drug targets for a variety of disorders associated with disrupted water or solute transport, including brain oedema following stroke or trauma, epilepsy, cancer cell migration and tumour angiogenesis, metabolic disorders, and inflammation. Despite this, drug discovery for AQPs ha...
Source: Biochimica et Biophysica Acta - January 1, 2022 Category: Biochemistry Authors: Andrea Markou Lucas Unger Mohammed Abir-Awan Ahmed Saadallah Andrea Halsey Zita Baklava Matthew Conner Susanna T örnroth-Horsefield Stuart D Greenhill Alex Conner Roslyn M Bill Mootaz M Salman Philip Kitchen Source Type: research
Myelin-associated glycoprotein activation triggers glutamate uptake by oligodendrocytes in vitro and contributes to ameliorate glutamate-mediated toxicity in vivo
CONCLUSIONS: MAG activation triggers Glu uptake into OLs under conditions of Glu overload and induces a robust protective antioxidant response.PMID:34954343 | DOI:10.1016/j.bbadis.2021.166324
Source: Biochimica et Biophysica Acta - December 26, 2021 Category: Biochemistry Authors: Ana L Vivinetto Clara Casta ñares Constanza Garcia-Keller Ana Lis Moyano Cristian Falcon Anabela Palandri Victoria Roz és-Salvador Juan I Rojas Liliana Patrucco Clara Monferran Liliana Cancela Edgardo Cristiano Ronald L Schnaar Pablo H H Lopez Source Type: research
