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MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway
This study aims to explore whether MALT1 is upregulated in the brain during ischemic stroke and promotes brain cell necroptosis through enhancing the degradation of A20. Ischemic stroke model was established in Sprague Dawley rats by occlusion of the middle cerebral artery (MCA) for 2 h, followed by 24 h reperfusion, which showed brain injury (increase in neurological deficit score and infarct volume) concomitant with an upregulation of MALT1, a decrease in A20 level, and increases in necroptosis-associated protein levels [RIPK3, mixed lineage kinase domain-like protein (MLKL) and p-MLKL] and k63-ubiquitination of RIPK3 in...
Source: Archives of Biochemistry and Biophysics - January 5, 2023 Category: Biochemistry Authors: Zi-Mei Peng Yi-Yue Zhang Dan Wei Xiao-Jie Zhang Bin Liu Jun Peng Xiu-Ju Luo Source Type: research

Exosomes from M2-polarized macrophages relieve oxygen/glucose deprivation/normalization-induced neuronal injury by activating the Nrf2/HO-1 signaling
In this study, we established an in vitro oxygen/glucose deprivation and re-oxygen/glucose (OGD/R) model to investigate the potential role of M2-Exo in protecting HT22 neurons against ischemia-reperfusion injury. Interleukin-4 was used to induce the M2 phenotype in macrophages, following which the exosomes were isolated from the supernatant of M2-polarized macrophages and identified by western blotting, transmission electron microscopy, and nanoparticle tracking analysis. After co-incubation with M2-Exo, OGD/R-induced neuronal injury in HT22 cells was improved, accompanied by increased cell viability and decreased lactate ...
Source: Archives of Biochemistry and Biophysics - March 24, 2022 Category: Biochemistry Authors: Tao Xiao Hongtao Qu Zhiqing Zeng Chuanghua Li Juan Wan Source Type: research

Effects of air pollution particles (ultrafine and fine particulate matter) on mitochondrial function and oxidative stress - Implications for cardiovascular and neurodegenerative diseases.
Abstract Environmental pollution is a major cause of global mortality and burden of disease. All chemical pollution forms together may be responsible for up to 12 million annual excess deaths as estimated by the Lancet Commission on pollution and health as well as the World Health Organization. Ambient air pollution by particulate matter (PM) and ozone was found to be associated with an all-cause mortality rate of up to 9 million in the year 2015, with the majority being of cerebro- and cardiovascular nature (e.g. stroke and ischemic heart disease). Recent evidence suggests that exposure to airborne particles and ...
Source: Archives of Biochemistry and Biophysics - November 4, 2020 Category: Biochemistry Authors: Daiber A, Kuntic M, Hahad O, Delogu LG, Rohrbach S, Di Lisa F, Schulz R, Münzel T Tags: Arch Biochem Biophys Source Type: research

Ablation of TMEM126B protects against oxygen-glucose deprivation/reoxygenation-induced injuries of PC12  cells via maintaining mitochondrial anti-apoptotic functions.
Ablation of TMEM126B protects against oxygen-glucose deprivation/reoxygenation-induced injuries of PC12 cells via maintaining mitochondrial anti-apoptotic functions. Arch Biochem Biophys. 2020 Oct 16;:108634 Authors: Wei L, Fan Y, Wei L, He X, Yang J, Zheng X Abstract Ischemia reperfusion (I/R) injury is a key contributing factor to the pathogenic mechanism involved in cerebral infarction. Transmembrane protein 126b (TMEM126B), a mitochondrial complex I assembly factor, has been reported to have an intimate association with disease progression, but is little known in ischemia stroke. The present stu...
Source: Archives of Biochemistry and Biophysics - October 16, 2020 Category: Biochemistry Authors: Wei L, Fan Y, Wei L, He X, Yang J, Zheng X Tags: Arch Biochem Biophys Source Type: research

The possible roles of necroptosis during cerebral ischemia and ischemia / reperfusion injury.
Abstract Cell death is a process consequential to cerebral ischemia and cerebral ischemia/reperfusion (I/R) injury. Recent evidence suggest that necroptosis has been involved in the pathogenesis of ischemic brain injury. The mechanism of necroptosis is initiated by an activation of inflammatory receptors including tumor necrosis factor, toll like receptor, and fas ligands. The signals activate the receptor-interacting protein kinase (RIPK) 1, 3, and a mixed-lineage kinase domain-like pseudokinase (MLKL) to instigate necroptosis. RIPK1 inhibitor, necrostatin-1, was developed, and dramatically reduced brain injury f...
Source: Archives of Biochemistry and Biophysics - October 14, 2020 Category: Biochemistry Authors: Liao S, Apaijai N, Chattipakorn N, Chattipakorn SC Tags: Arch Biochem Biophys Source Type: research

Phoenixin 14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia.
Abstract The process of ischemia/reperfusion (IR) in ischemic stroke often leads to significant cell death and permanent neuronal damage. Safe and effective treatments are urgently needed to mitigate the damage caused by IR injury. The naturally occurring pleiotropic peptide phoenixin 14 (PNX-14) has recently come to light as a potential treatment for IR injury. In the present study, we examined the effects of PNX-14 on several key processes involved in ischemic injury, such as pro-inflammatory cytokine expression, oxidative stress, and the related cascade mediated through the toll-like receptor 4 (TLR4) pathway, ...
Source: Archives of Biochemistry and Biophysics - May 21, 2020 Category: Biochemistry Authors: Ma H, Su D, Wang Q, Chong Z, Zhu Q, He W, Wang W Tags: Arch Biochem Biophys Source Type: research

Phoenixin-14 protects human brain vascular endothelial cells against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced inflammation and permeability.
Abstract Stroke is one of the world's most deadly pathologies, and the rate of stroke recurrence is high. However, due to the complex nature of ischemia and reperfusion injury, there is presently no reliable treatment. The main factors driving brain damage from ischemic stroke are neuronal cell death resulting from oxidative stress, inflammation, and failure of the blood brain barrier. While under normal conditions, the blood brain barrier acts as a selectively permeable membrane allowing solutes and other substances to pass into the tissues of the central nervous system, ischemia and reperfusion alter the express...
Source: Archives of Biochemistry and Biophysics - January 17, 2020 Category: Biochemistry Authors: Zhang B, Li J Tags: Arch Biochem Biophys Source Type: research

Micro RNA 146a gene variant / TNF- α/ IL-6/ IL-1 β; A cross-link axis inbetween oxidative stress, endothelial dysfunction and neuro-inflammation in acute ischemic stroke and chronic schizophrenic patients.
Micro RNA 146a gene variant / TNF-α/ IL-6/ IL-1 β; A cross-link axis inbetween oxidative stress, endothelial dysfunction and neuro-inflammation in acute ischemic stroke and chronic schizophrenic patients. Arch Biochem Biophys. 2019 Nov 15;:108193 Authors: Ibrahim RR, Amer RA, Abozeid AA, Elsharaby RM, Shafik NM Abstract This work was purposed to speculate the possible association of rs2910164hsa-miR-146a C>G gene single nucleotide polymorphism in the pathogenesis of schizophrenia and subsequently their relevance to neuro-inflammatory, vascular and oxidative stress pathways as acute ischemic strok...
Source: Archives of Biochemistry and Biophysics - November 14, 2019 Category: Biochemistry Authors: Ibrahim RR, Amer RA, Abozeid AA, Elsharaby RM, Shafik NM Tags: Arch Biochem Biophys Source Type: research

Carbon monoxide attenuates vasospasm and improves neurobehavioral function after subarachnoid hemorrhage.
Abstract Subarachnoid hemorrhage (SAH) is a devastating form of hemorrhagic stroke and is a serious medical condition caused by bleeding usually due to a ruptured aneurysm. Oxidative stress and inflammation from hemoglobin and heme released from lysed red blood cells are some postulated causes of vasospasm during SAH, which could lead to delayed cerebral ischemia. At low amounts, carbon monoxide (CO) gas may be neuroprotective through anti-inflammation, anti-cell death, and restoration of normal blood flow. Hence, this study focuses on a noninvasive strategy to treat SAH by using CO as therapeutic medical gas. Mic...
Source: Archives of Biochemistry and Biophysics - September 23, 2019 Category: Biochemistry Authors: Kamat PK, Ahmad AS, Doré S Tags: Arch Biochem Biophys Source Type: research

Research trends in flavonoids and health.
Abstract Herein we describe, based on some bibliometric data, how the field of research on flavonoids has evolved over the last 25 years. The number of papers on flavonoids has risen in an exponential manner over these years, much faster than other fields on food constituents. This increase appears to be related to the contemporary explosion of interest in healthy foods, supplements and nutraceuticals. It was also probably triggered by large epidemiological studies on fruits and vegetables, and particularly on flavonoids, consumption and incidence of cancer, stroke and coronary heart disease. The widely distribute...
Source: Archives of Biochemistry and Biophysics - March 23, 2018 Category: Biochemistry Authors: Perez-Vizcaino F, Fraga CG Tags: Arch Biochem Biophys Source Type: research

In vitro actin motility velocity varies linearly with the number of myosin impellers.
Abstract Cardiac myosin is the motor powering the heart. It moves actin with 3 step-size varieties generated by torque from the myosin heavy chain lever-arm rotation under the influence of myosin essential light chain whose N-terminal extension binds actin. Proposed mechanisms adapting myosin mechanochemical characteristics on the fly sometimes involve modulation of step-size selection probability via motor strain sensitivity. Strain following the power stroke, hypothetically imposed by the finite actin detachment rate 1/ton, is shown to have no effect on unloaded velocity when multiple myosins are simultaneously ...
Source: Archives of Biochemistry and Biophysics - January 24, 2017 Category: Biochemistry Authors: Wang Y, Burghardt TP Tags: Arch Biochem Biophys Source Type: research

Role of heparin and non heparin binding serpins in coagulation and angiogenesis: A complex interplay.
Abstract Pro-coagulant, anti-coagulant and fibrinolytic pathways are responsible for maintaining haemostatic balance under physiological conditions. Any deviation from these pathways would result in hypercoagulability leading to life threatening diseases like myocardial infarction, stroke, portal vein thrombosis, deep vein thrombosis (DVT) and pulmonary embolism (PE). Angiogenesis is the process of sprouting of new blood vessels from pre-existing ones and plays a critical role in vascular repair, diabetic retinopathy, chronic inflammation and cancer progression. Serpins; a superfamily of protease inhibitors, play ...
Source: Archives of Biochemistry and Biophysics - June 28, 2016 Category: Biochemistry Authors: Bhakuni T, Ali MF, Ahmad I, Bano S, Ansari S, Jairajpuri MA Tags: Arch Biochem Biophys Source Type: research

MicroRNA-182 aggravates cerebral ischemia injury by targeting inhibitory member of the ASPP family (iASPP).
In conclusion, miR-182 plays an aggressive role in the cerebral ischemia injury, and this is associated with inhibited iASPP expression. PMID: 27242323 [PubMed - as supplied by publisher]
Source: Archives of Biochemistry and Biophysics - May 26, 2016 Category: Biochemistry Authors: Yi H, Huang Y, Yang F, Liu W, He S, Hu X Tags: Arch Biochem Biophys Source Type: research

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