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Comparison of the differentiation of dental pulp stem cells and periodontal ligament stem cells into neuron-like cells and their effects on focal cerebral ischemia.
In this study, the in vitro differentiation of DPSCs and PDLSCs into neuron-like cells was evaluated. Then, we established a rat model of cerebral ischemia. DPSCs or PDLSCs were administered to animals, and the therapeutic effects of these two types of cells were investigated. The results showed that PDLSCs had a higher differentiation rate than DPSCs. Immunofluorescence studies showed that the expression of the neuronal differentiation marker Thy-1 was higher in PDLSCs than in DPSCs, and other gene markers of neuronal differentiation showed corresponding trends, which were confirmed by western blot analysis. In this proce...
Source: Acta Biochimica et Biophysica Sinica - August 25, 2020 Category: Biochemistry Authors: Wu T, Xu W, Chen H, Li S, Dou R, Shen H, Liu X, Liu X, Hong Y, He J Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

Relationship between olfactory disturbance after acute ischemic stroke and latent thalamic hypoperfusion.
Abstract Odor detection, recognition and identification were assessed in 19 acute ischemic stroke patients who had no MRI-detectable thalamic lesions but in whom technetium-99m ethyl cysteinate dimer single photon emission tomography revealed thalamic hypoperfusion. Although these patients were unaware of reduced olfactory function, they exhibited significantly lower scores in tests for odor identification and recognition threshold as compared to 9 ischemic stroke controls that had normal thalamic hypoperfusion. However, absolute odor detection thresholds were similar in the two groups. These results demonstrate t...
Source: Chemical Senses - December 23, 2019 Category: Biochemistry Authors: Okamoto K, Shiga H, Nakamura H, Matsui M, Miwa T Tags: Chem Senses Source Type: research