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Is early age at menarche associated with multimorbidity? Findings from the Azar Cohort study
CONCLUSION: Changes in AAM have significant health implications. Factors predisposing individuals to early menarche and its consequences should be considered in chronic disease prevention strategies for adolescents and young adults.PMID:37290234 | DOI:10.1016/j.ejogrb.2023.05.029
Source: Reproductive Biology - June 8, 2023 Category: Reproduction Medicine Authors: Amin SadrAzar Sarvin Sanaie Helda Tutunchi Bahare Sheikh Elnaz Faramarzi Neda Jourabchi-Ghadim Source Type: research

Surgical results in POP/UI surgery after using PVDF compared to other materials. A systematic review and meta-analysis
CONCLUSIONS: This study provided evidence that the use of PVDF in SUI/POP surgeries could be a valid alternative to PP. However our results are limited by uncertainty due to the overall low quality of the existent data. Further research and validation would contribute to better surgical techniques.PMID:36966589 | DOI:10.1016/j.ejogrb.2023.03.018
Source: Reproductive Biology - March 26, 2023 Category: Reproduction Medicine Authors: Tilemachos Karalis Sofia Tsiapakidou Grigoris F Grimbizis Themistoklis Mikos Source Type: research

Reproductive complications after stroke: long-lasting impairment of GnRH neuronal network?
Biol Reprod. 2022 Apr 26:ioac080. doi: 10.1093/biolre/ioac080. Online ahead of print.ABSTRACTSome studies have demonstrated that stroke may increase the risk of pregnancy complications and early menopause. In addition, preclinical investigations revealed the middle cerebral artery occlusion could affect hypothalamus. Since hypothalamus is the core of central circuits regulating reproductive processes, impairment of hypothalamic GnRH neuronal network following stroke might be manifested in long-lasting reproductive disorders.PMID:35470856 | DOI:10.1093/biolre/ioac080
Source: Reproductive Biology - April 26, 2022 Category: Reproduction Medicine Authors: Mohammad Saied Salehi Sareh Pandamooz Amin Tamadon Mohammad Reza Jafarzadeh Shirazi Afshin Borhani-Haghighi Source Type: research

Neonatal outcomes and risk of neonatal sepsis in an expectantly managed cohort of late preterm prelabor rupture of membranes
CONCLUSION: Expectant management of LpPROM should be encouraged especially between 34+0 and 34+6 weeks', when the burden of prematurity is the greatest. Antibiotics may have beneficial effects, while careful consideration should be given to antenatal corticosteroids until future studies specifically address LpPROM.PMID:33857797 | DOI:10.1016/j.ejogrb.2021.03.036
Source: Reproductive Biology - April 15, 2021 Category: Reproduction Medicine Authors: Giuseppe Chiossi Mariarosaria Di Tommaso Francesca Monari Sara Consonni Noemi Strambi Sofia Gambigliani Zoccoli Viola Seravalli Chiara Comerio Marta Betti Anna Cappello Patrizia Vergani Fabio Facchinetti Anna Locatelli Source Type: research

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro.
CONCLUSIONS: Our results show an inhibitory action of progesterone in the aldosterone synthesis by chimeric or wild type aldosterone synthase enzymes. This is a novel regulatory mechanism of progesterone action, which could be involved in protecting pregnant women with FH-1 against hypertension. In vitro, both enzymes showed comparable kinetic parameters, but ASWT was more strongly inhibited than ASCE. This study implicates a new role for progesterone in the regulation of aldosterone levels that could contribute, along with other factors, to the maintenance of an adequate aldosterone-progesterone balance in pregnancy. ...
Source: Reproductive Biology - August 13, 2013 Category: Reproduction Medicine Authors: Vecchiola A, Lagos CF, Fuentes CA, Allende F, Campino C, Valdivia C, Tapia-Castillo A, Ogishima T, Mukai K, Owen G, Solari S, Carvajal CA, Fardella CE Tags: Reprod Biol Endocrinol Source Type: research