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Specialty: Epidemiology
Source: Adv Data
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Total 119 results found since Jan 2013.
Comparing Cardiovascular Outcomes and Costs of Perindopril-, Enalapril- or Losartan-Based Antihypertensive Regimens in South Africa: Real-World Medical Claims Database Analysis
CONCLUSION: In South African individuals with private health insurance, a perindopril-based antihypertensive regimen provided better clinical and cost outcomes compared with other regimens.PMID:37730949 | DOI:10.1007/s12325-023-02641-8
Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Jacques R Snyman Freedom Gumedze Erika S W Jones Olufunke A Alaba Nqoba Tsabedze Alykhan Vira Ntobeko A B Ntusi Source Type: research
Long-term exposure to ambient ozone and cardiovascular diseases: evidence from two national cohort studies in China
CONCLUSIONS: Long-term exposure to MDA8 O3 may increase the incidence of CVD. Therefore, the policies that control O3 and related precursors are persistently needed.PMID:37625570 | DOI:10.1016/j.jare.2023.08.010
Source: Adv Data - August 25, 2023 Category: Epidemiology Authors: Shuru Liang Yumeng Chen Xiaoli Sun Xiaomei Dong Guanhao He Yudong Pu Jingjie Fan Xinqi Zhong Zhiqing Chen Ziqiang Lin Wenjun Ma Tao Liu Source Type: research
Calcium Sensors of Neurotransmitter Release
Adv Neurobiol. 2023;33:119-138. doi: 10.1007/978-3-031-34229-5_5.ABSTRACTCalcium (Ca2+) plays a critical role in triggering all three primary modes of neurotransmitter release (synchronous, asynchronous, and spontaneous). Synaptotagmin1, a protein with two C2 domains, is the first isoform of the synaptotagmin family that was identified and demonstrated as the primary Ca2+ sensor for synchronous neurotransmitter release. Other isoforms of the synaptotagmin family as well as other C2 proteins such as the double C2 domain protein family were found to act as Ca2+ sensors for different modes of neurotransmitter release. Major r...
Source: Adv Data - August 24, 2023 Category: Epidemiology Authors: Qiangjun Zhou Source Type: research
Phenotypes of undiagnosed adults with actionable < em > OTC < /em > and < em > GLA < /em > variants
HGG Adv. 2023 Jul 29;4(4):100226. doi: 10.1016/j.xhgg.2023.100226. eCollection 2023 Oct 12.ABSTRACTInherited metabolic disorders (IMDs) are variably expressive, complicating identification of affected individuals. A genotype-first approach can identify individuals at risk for morbidity and mortality from undiagnosed IMDs and can lead to protocols that improve clinical detection, counseling, and management. Using data from 57,340 participants in two hospital biobanks, we assessed the frequency and phenotypes of individuals with pathogenic/likely pathogenic variants (PLPVs) in two IMD genes: GLA, associated with Fabry diseas...
Source: Adv Data - August 18, 2023 Category: Epidemiology Authors: Jessica I Gold Sarina Madhavan Joseph Park Hana Zouk Emma Perez Alanna Strong Theodore G Drivas Amel Karaa Marc Yudkoff Daniel Rader Regeneron Genetics Center Penn Medicine BioBank Robert C Green Nina B Gold Source Type: research
USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2
Adv Sci (Weinh). 2023 Aug 16:e2301641. doi: 10.1002/advs.202301641. Online ahead of print.ABSTRACTCerebral ischemic stroke is a leading cause of morbidity and mortality globally. However, the mechanisms underlying ischemic stroke injury remain poorly understood. Here, it is found that deficiency of the ubiquitin-specific protease USP25 significantly aggravate ischemic stroke injury in mice. USP25 has no impact on neuronal death under hypoxic conditions, but reduced ischemic stroke-induced neuronal loss and neurological deficits by inhibiting microglia-mediated neuroinflammation. Mechanistically, USP25 restricts the activat...
Source: Adv Data - August 17, 2023 Category: Epidemiology Authors: Zhongding Li Baohua Liu Kate Lykke Lambertsen Bettina Hjelm Clausen Zhenhu Zhu Xue Du Yanqi Xu Frantz Rom Poulsen Bo Halle Christian Bonde Meng Chen Xue Wang Dirk Schl üter Jingyong Huang Ari Waisman Weihong Song Xu Wang Source Type: research
Unintended Consequences of Increased Out-of-Pocket Costs During Medicare Coverage Gap on Anticoagulant Discontinuation and Stroke
CONCLUSION: Increased OOP costs during Medicare coverage gap were associated with higher risk of DOAC discontinuation, which in turn was associated with higher risk of stroke and SE among beneficiaries with NVAF.PMID:37568060 | DOI:10.1007/s12325-023-02620-z
Source: Adv Data - August 11, 2023 Category: Epidemiology Authors: Tabassum Salam Urvi Desai Patrick Lefebvre E Jian-Yu Alexandra Greatsinger Nina Zacharia Fran çois Laliberté Brahim Bookhart Akshay Kharat Source Type: research
Hierarchical Development of Physical Frailty and Cognitive Impairment and Their Association With Incident Cardiovascular Disease
CONCLUSIONS: The simultaneous development of frailty and CI is associated with an increased risk of adverse cardiovascular outcomes including death compared with the development of each syndrome alone. Diagnostics to detect frailty and CI are critical in assessment of cardiovascular risk in the older population.PMID:37538136 | PMC:PMC10399211 | DOI:10.1016/j.jacadv.2023.100318
Source: Adv Data - August 4, 2023 Category: Epidemiology Authors: Abdulla A Damluji Naila Ijaz Shang-En Chung Qian-Li Xue Rani K Hasan Wayne B Batchelor Ariela R Orkaby Ajar Kochar Michael G Nanna David L Roth Jeremy D Walston Jon R Resar Gary Gerstenblith Source Type: research
What Is the Role of Transcarotid Artery Revascularization?
Adv Surg. 2023 Sep;57(1):115-140. doi: 10.1016/j.yasu.2023.04.010. Epub 2023 May 26.ABSTRACTCarotid endarterectomy (CEA) is the gold-standard method of carotid revascularization in symptomatic patients with ≥50% and in asymptomatic patients with ≥70% stenosis. Transfemoral carotid artery stenting (TFCAS) has been associated with higher perioperative stroke rates compared to CEA in several studies. On the other hand, transcarotid artery revascularization (TCAR) has outperformed TFCAS in patients who are considered high risk for surgery. There is increasing data that supports TCAR as a safe and efficient technique with o...
Source: Adv Data - August 3, 2023 Category: Epidemiology Authors: Sina Zarrintan Mahmoud B Malas Source Type: research
Global Economic Burden Associated with Chronic Kidney Disease: A Pragmatic Review of Medical Costs for the Inside CKD Research Programme
CONCLUSION: Globally, CKD carries a significant economic burden, which increases substantially with increasing disease severity. We identified significant gaps in published costs and inconsistent costing definitions. Cost-effective interventions that target primary prevention and disease progression are essential to reduce CKD burden. Our results can be used to guide cost collection and facilitate better comparisons across countries/regions to inform healthcare policy.PMID:37493856 | DOI:10.1007/s12325-023-02608-9
Source: Adv Data - July 26, 2023 Category: Epidemiology Authors: Vivekanand Jha Saeed M G Al-Ghamdi Guisen Li Mai-Szu Wu Panagiotis Stafylas Lise Retat Joshua Card-Gowers Salvatore Barone Claudia Cabrera Juan Jose Garcia Sanchez Source Type: research
Dyadic psycho-social interventions for stroke survivors and family caregivers: A systematic review and meta-analysis of randomized controlled trials
CONCLUSIONS: This study provided moderate support for the benefits of dyadic psycho-social intervention in improving survivor and caregiver's functional independence, quality of life, depression, anxiety, self-efficacy and care burden. Nevertheless, due to limitations of the study, it was deemed necessary that this topic is studied further.RELEVANCE TO CLINICAL PRACTICE: This review suggests that dyadic psycho-social interventions should be considered as effective strategies for decreasing psycho-social problems of stroke survivors and caregivers, and provides evidence for the formulation of targeted intervention programs....
Source: Adv Data - July 13, 2023 Category: Epidemiology Authors: Xin-Yue Zhang Kai-Hui Sha Xue-Ying Ma Xue-Mei Li Ming-Hui Zhang Source Type: research
