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Mechanisms of Stroke in Patients with Chronic Kidney Disease.
Abstract BACKGROUND: Given the increasing worldwide prevalence of chronic kidney disease (CKD), it is critical to decrease the associated risk of debilitating vascular complications, including stroke, congestive heart failure, myocardial infarction, and peripheral vascular disease. Treatment options for reducing the risk of all subtypes of stroke in patients with CKD remain limited. For patients with end-stage kidney disease (ESKD), novel applications of noninvasive imaging may help personalize the type of dialysis and dialysis prescription for patients at high-risk. SUMMARY: This manuscript reviews the heigh...
Source: American Journal of Nephrology - August 27, 2019 Category: Urology & Nephrology Authors: Ghoshal S, Freedman BI Tags: Am J Nephrol Source Type: research

Association of Dyskalemias with Ischemic Stroke in Advanced Chronic Kidney Disease Patients Transitioning to Dialysis
CONCLUSION: In patients with advanced CKD, hypokalemia (chronic exposure) was associated with a higher risk of ischemic stroke, whereas hyperkalemia (acute exposure) was associated with a lower risk of ischemic stroke. Further studies in this population are needed to explore the mechanisms underlying these associations.PMID:34289468 | DOI:10.1159/000516902
Source: American Journal of Nephrology - July 21, 2021 Category: Urology & Nephrology Authors: Ankur A Dashputre Keiichi Sumida Fridtjof Thomas Justin Gatwood Oguz Akbilgic Praveen K Potukuchi Yoshitsugu Obi Miklos Z Molnar Elani Streja Kamyar Kalantar Zadeh Csaba P Kovesdy Source Type: research

Chronic Kidney Disease Awareness and Longitudinal Health Outcomes: Results from the REasons for Geographic And Racial Differences in Stroke Study.
CONCLUSIONS: Individuals aware of their CKD were more likely to experience ESKD and death, suggesting that CKD awareness reflects disease severity. Most persons with CKD, including those that are high-risk, remain unaware of their CKD. There was no evidence of associations between baseline CKD awareness and longitudinal health behaviors, CKD management indicators, or eGFR decline and albuminuria. PMID: 32349001 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - April 28, 2020 Category: Urology & Nephrology Authors: Tummalapalli SL, Vittinghoff E, Crews DC, Cushman M, Gutiérrez OM, Judd SE, Kramer HJ, Peralta CA, Tuot DS, Shlipak MG, Estrella MM Tags: Am J Nephrol Source Type: research

Increased Incident Ischemic Stroke Risk in Advanced Kidney Disease: A Large-Scale Real-World Data Study.
CONCLUSION: Although we found that OAC use was effective and recommended for patients with AF, advanced kidney disease is still an independent risk factor for IS/SE, even in patients taking OAC. Physicians should be aware of this risk and strictly control modifiable risk factors, regardless of OAC use. PMID: 32726780 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - July 28, 2020 Category: Urology & Nephrology Authors: Maeda T, Nishi T, Funakoshi S, Tada K, Tsuji M, Satoh A, Kawazoe M, Yoshimura C, Arima H Tags: Am J Nephrol Source Type: research

Both Chronic Kidney Disease and Nocturnal Blood Pressure Associate with Strokes in the Elderly.
Conclusion: In elderly hypertensive patients, both high nocturnal SBP and CKD are independent risk factors for stroke. © 2013 S. Karger AG, Basel. PMID: 23970169 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - August 21, 2013 Category: Urology & Nephrology Authors: Yano Y, Bakris GL, Matsushita K, Hoshide S, Shimada K, Kario K Tags: Am J Nephrol Source Type: research

Cardiovascular Outcomes in Action to Control Cardiovascular Risk in Diabetes: Impact of Blood Pressure Level and Presence of Kidney Disease.
CONCLUSIONS: These findings suggest that intensive antihypertensive therapy offers significant cerebrovascular protection in diabetic participants without CKD at baseline, but significant benefit to patients with CKD cannot be excluded. PMID: 27161620 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - April 28, 2016 Category: Urology & Nephrology Authors: Papademetriou V, Zaheer M, Doumas M, Lovato L, Applegate WB, Tsioufis C, Mottle A, Punthakee Z, Cushman WC, ACCORD Study Group Tags: Am J Nephrol Source Type: research

Patients' Characteristics Affect the Survival Benefit of Warfarin Treatment for Hemodialysis Patients with Atrial Fibrillation. A Historical Cohort Study.
CONCLUSION: VKA may provide an early survival benefit; however, this is partially offset later during the follow-up. In addition, heterogeneous risk-benefit profiles were observed among subgroups of dialysis-dependent patients with AF, further emphasizing the complexities of tailoring stroke prevention strategies in this population. PMID: 27598317 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - September 6, 2016 Category: Urology & Nephrology Authors: Brancaccio D, Neri L, Bellocchio F, Barbieri C, Amato C, Mari F, Canaud B, Stuard S Tags: Am J Nephrol Source Type: research

Assessment of the CHA2DS2-VASc Score in Predicting Mortality and Adverse Cardiovascular Outcomes of Patients on Hemodialysis.
CONCLUSIONS: Patients with ESRD are at an extremely high mortality and cardiovascular risk within the first year of hemodialysis. The CHA2DS2-VASc score was strongly associated with adverse outcomes and may be used for risk stratification of these patients. PMID: 32702703 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - July 21, 2020 Category: Urology & Nephrology Authors: Schamroth Pravda M, Cohen Hagai K, Topaz G, Schamroth Pravda N, Makhoul N, Shuvy M, Benchetrit S, Assali A, Pereg D Tags: Am J Nephrol Source Type: research

Impact of Non-Adherence on Renal and Cardiovascular Outcomes in US Veterans.
CONCLUSIONS: Assignment of V15.81 code prior to AHD therapy was associated with higher risks of renal and cardiovascular outcomes in incident hypertensive US veterans. Previous history of non-adherence is a poor prognostic marker in hypertensive individuals; therefore, patients with V15.81 code may require close monitoring. The observational nature of this study limits our ability to make firm recommendations for clinical practice. PMID: 26398170 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - September 24, 2015 Category: Urology & Nephrology Authors: Gosmanova EO, Molnar MZ, Alrifai A, Lu JL, Streja E, Cushman WC, Kalantar-Zadeh K, Kovesdy CP Tags: Am J Nephrol Source Type: research

Serum Bicarbonate Is Associated with Heart Failure in the Multi-Ethnic Study of Atherosclerosis.
CONCLUSION: Among nonusers of diuretics in a large community-based study, higher serum bicarbonate concentrations are associated with subclinical CVD and new heart failure. PMID: 27941322 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - December 9, 2016 Category: Urology & Nephrology Authors: Kendrick JB, Zelnick L, Chonchol MB, Siscovick D, Hoofnagle AN, Ix JH, Sarnak M, Shlipak MG, Kestenbaum B, de Boer IH Tags: Am J Nephrol Source Type: research

Randomized Trial Comparing Proactive, High-Dose versus Reactive, Low-Dose Intravenous Iron Supplementation in Hemodialysis (PIVOTAL): Study Design and Baseline Data.
CONCLUSIONS: PIVOTAL will provide important information about the optimum dosing of IV iron in HD patients representative of usual clinical practice. TRIAL REGISTRATION: EudraCT number: 2013-002267-25. PMID: 30304714 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - October 10, 2018 Category: Urology & Nephrology Authors: Macdougall IC, White C, Anker SD, Bhandari S, Farrington K, Kalra PA, McMurray JJV, Murray H, Steenkamp R, Tomson CRV, Wheeler DC, Winearls CG, Ford I, on behalf of the PIVOTAL Trial investigators Tags: Am J Nephrol Source Type: research

Determinants of Cardiovascular Risk in Haemodialysis Patients: Post hoc Analyses of the AURORA Study.
Conclusions : Although we identify CRP, low albumin, and high phosphorus as risk factors for MACE, lowering CRP did not influence MACE outcomes in our trial. Caution is therefore warranted in implying risk factors being causal in end-stage renal disease. PMID: 23392089 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - January 31, 2013 Category: Urology & Nephrology Authors: Schneider A, Jardine AG, Schneider MP, Holdaas H, Holme I, Fellstroem BC, Zannad F, Schmieder RE Tags: Am J Nephrol Source Type: research

Healthy Behaviors, Risk Factor Control and Awareness of Chronic Kidney Disease.
Conclusions: Awareness of CKD was only associated with participation in one healthy behavior and was not associated with achievement of risk-reduction targets. To encourage adoption of healthy behaviors, a better understanding of barriers to participation in CKD-healthy behaviors is needed. PMID: 23392070 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - January 31, 2013 Category: Urology & Nephrology Authors: Tuot DS, Plantinga LC, Judd SE, Muntner P, Hsu CY, Warnock DG, Gutiérrez OM, Safford M, Powe NR, McClellan WM Tags: Am J Nephrol Source Type: research

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