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Life interrupted and life regained? Coping with stroke at a young age.
Authors: Kuluski K, Dow C, Locock L, Lyons RF, Lasserson D Abstract Stroke is a leading cause of disability across the developed world, affecting an increasing number of younger people. In this article, we seek to understand the experience of stroke as a disabling life situation among young people and the strategies that they use to recover and cope. Directed content analysis was conducted from interviews with 17 community-dwelling stroke survivors aged 55 years and younger across the United Kingdom. The sample was drawn from a larger maximum variation sample of stroke survivors. Using the sociological concepts of ...
Source: International Journal of Qualitative Studies on Health and Well-being - June 2, 2017 Category: International Medicine & Public Health Tags: Int J Qual Stud Health Well-being Source Type: research

USF study: Blood-brain barrier repair after stroke may prevent chronic brain deficits
(University of South Florida (USF Innovation)) Following ischemic stroke, the integrity of the blood-brain barrier, which prevents harmful substances such as inflammatory molecules from entering the brain, can be impaired in cerebral areas distant from initial ischemic insult. This disruptive condition, known as diaschisis, can lead to chronic post-stroke deficits, University of South Florida researchers report in a recent issue of the Journal of Comparative Neurology.
Source: EurekAlert! - Social and Behavioral Science - March 25, 2014 Category: Global & Universal Source Type: news

Future heat stroke treatment found in dental pulp stem cells
(Cell Transplantation Center of Excellence for Aging and Brain Repair) Intravenous injections of stem cells derived from human exfoliated deciduous tooth pulp have a protective effect in mice against brain damage from heat stroke. The cells had significantly higher proliferation rates than bone marrow-derived stem cells, were easy to harvest, and expressed growth factors, including vascular endothelial growth factor, that promoted the migration and differentiation of neuronal progenitor cells. The procedure could treat human patients by preventing the neurological damage caused by heat stroke.
Source: EurekAlert! - Medicine and Health - June 5, 2014 Category: Global & Universal Source Type: news

First non-human primate study showing promise of gene therapy for stroke repair
(Guangdong-Hongkong-Macau Institute of CNS Regeneration,Jinan University) Stroke is a leading cause of death and severe long-term disability with limited treatment available. A research team led by Prof. Gong Chen at Jinan University, Guangzhou, China recently reported the first non-human primate study demonstrating successful in vivo neural regeneration from brain internal glial cells for stroke repair. This work was published on Frontiers in Cell and Developmental Biology on November 5th, 2020.
Source: EurekAlert! - Medicine and Health - November 13, 2020 Category: International Medicine & Public Health Source Type: news

Stem cells aid recovery from stroke
(BioMed Central) Stem cells from bone marrow or fat improve recovery after stroke in rats, finds a study published in BioMed Central's open access journal Stem Cell Research & Therapy. Treatment with stem cells improved the amount of brain and nerve repair and the ability of the animals to complete behavioral tasks.
Source: EurekAlert! - Medicine and Health - January 27, 2013 Category: Global & Universal Source Type: news

Chemical reaction keeps stroke-damaged brain from repairing itself
(Sanford-Burnham Medical Research Institute) Nitric oxide, a gaseous molecule produced in the brain, can damage neurons. When the brain produces too much nitric oxide, it contributes to the severity and progression of stroke and neurodegenerative diseases such as Alzheimer's. Researchers at Sanford-Burnham Medical Research Institute recently discovered that nitric oxide not only damages neurons, it also shuts down the brain's repair mechanisms. Their study was published Feb. 4 by the Proceedings of the National Academy of Sciences.
Source: EurekAlert! - Medicine and Health - February 4, 2013 Category: Global & Universal Source Type: news

USF researchers find far-reaching, microvascular damage in uninjured side of brain after stroke
(University of South Florida (USF Health)) An animal-model study led by researchers at the University of South Florida finds far-reaching microvascular damage in the uninjured side of the brain after a stroke. The findings suggest repair of the protective blood-brain barrier may help prevent this breach in the days following the acute injury.
Source: EurekAlert! - Medicine and Health - May 20, 2013 Category: Global & Universal Source Type: news

A new weapon against stroke
(University of California - Davis Health System) Stem cell research for stroke has focused on developing therapeutic neurons -- the primary movers of electrical impulses in the brain -- to repair tissue damaged when oxygen to the brain is limited by a blood clot or break in a vessel. New UC Davis research, however, shows that other cells may be better suited for the task.
Source: EurekAlert! - Medicine and Health - July 23, 2013 Category: Global & Universal Source Type: news

Stroke researchers report improvement in spatial neglect with prism adaptation therapy
(Kessler Foundation) Stroke rehabilitation researchers report improvement in spatial neglect with prism adaptation therapy. This new study supports behavioral classification of patients with spatial neglect as a valuable tool for assigning targeted, effective early rehabilitation with prism adaptation. Results of the study, "Presence of motor-intentional aiming deficit predicts functional improvement of spatial neglect with prism adaptation" DOI: 10.1177/1545968313516872 were published ahead of print in Neurorehabilitation and Neural Repair on December 27, 2013.
Source: EurekAlert! - Social and Behavioral Science - December 27, 2013 Category: Global & Universal Source Type: news

Akt Pathway 'ramp ups' effects of transplanted umbilical cord cells used in stroke therapy
(Cell Transplantation Center of Excellence for Aging and Brain Repair) Researchers found that transplanted human umbilical cord blood cells (HUCBCs) are beneficial in preventing neuron loss when the Akt signaling pathway is activated by HUCBC secretions, and the subsequent Akt activation impacts a specific gene involved in reducing inflammation. A reduction in inflammation helps neural cell survival following stroke. The Akt pathway has been shown to be important because it activates the peroxiredoxin 5 (Prdx5) gene, an antioxidant enzyme that reduces hydrogen peroxide and inflammation.
Source: EurekAlert! - Medicine and Health - February 9, 2015 Category: Global & Universal Source Type: news

Immune cells help the brain to self-heal after a stroke
(Lund University) After a stroke, there is inflammation in the damaged part of the brain. Until now, the inflammation has been seen as a negative consequence that needs to be abolished as soon as possible. But, as it turns out, there are also some positive sides to the inflammation, and it can actually help the brain to self-repair.
Source: EurekAlert! - Medicine and Health - April 15, 2016 Category: Global & Universal Source Type: news

First evidence of ischemia-induced multipotent stem cells in post-stroke human brain
(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers have shown that following a stroke-induced ischemic injury to the human brain, stem cells are produced that have the potential to differentiate and mature to form neurons that can help repair the damage to the brain.
Source: EurekAlert! - Medicine and Health - May 3, 2017 Category: Global & Universal Source Type: news

UTHealth discovers how to train damaging inflammatory cells to promote repair after stroke
(University of Texas Health Science Center at Houston) Researchers at McGovern Medical School at UTHealth have discovered a way to turn neutrophils from toxic to helpful after a hemorrhagic stroke.
Source: EurekAlert! - Medicine and Health - September 19, 2017 Category: International Medicine & Public Health Source Type: news

Researchers successfully repair stroke-damaged rat brains
(Lund University) Researchers at Lund University in Sweden have succeeded in restoring mobility and sensation of touch in stroke-afflicted rats by reprogramming human skin cells to become nerve cells, which were then transplanted into the rats' brains. The study has now been published in the research journal PNAS.
Source: EurekAlert! - Medicine and Health - April 8, 2020 Category: International Medicine & Public Health Source Type: news

Agenda set for upcoming CRF-sponsored conference on stem cell therapy for heart disease
(Cardiovascular Research Foundation) The 8th International Conference on Cell Therapy for Cardiovascular Disease, sponsored by the Cardiovascular Research Foundation will be held Jan. 23-25, 2013. The conference is a comprehensive program dedicated to the evolving field of cell-based therapies for the repair and regeneration of cardiac and vascular disease, as well as related diseases such as diabetes and stroke.
Source: EurekAlert! - Medicine and Health - January 3, 2013 Category: Global & Universal Source Type: news

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