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The Mechanoreflex and Hemodynamic Response to Passive Leg Movement in Heart Failure
Background: Sensitization of mechanosensitive afferents, which contribute to the exercise pressor reflex, has been recognized as a characteristic of patients with heart failure (HF); however, the hemodynamic implications of this hypersensitivity are unclear. Objectives: The present study used passive leg movement (PLM) and intrathecal injection of fentanyl to blunt the afferent portion of this reflex arc to better understand the role of the mechanoreflex on central and peripheral hemodynamics in HF. Methods: Femoral blood flow (FBF), mean arterial pressure, femoral vascular conductance, HR, stroke volume, cardiac output,...
Source: Medicine and Science in Sports and Exercise - February 19, 2016 Category: Sports Medicine Tags: Basic Sciences Source Type: research