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DROSHA rs10719 and DICER1 rs3742330 polymorphisms in endometriosis and different diseases: Case-control and review studies.
CONCLUSIONS: The results suggest that only the DICER1 rs3742330 A > G polymorphism may be associated with susceptibility to endometriosis. The frequencies of both polymorphisms were significantly different among populations, and there were discrepancies in the risk associations with the development of diseases. PMID: 33535080 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - January 31, 2021 Category: Pathology Authors: Cardoso JV, Medeiros R, Dias F, Costa IA, Ferrari R, Berardo PT, Perini JA Tags: Exp Mol Pathol Source Type: research

miR-188-5p inhibits apoptosis of neuronal cells during oxygen-glucose deprivation (OGD)-induced stroke by suppressing PTEN.
Abstract The miRNAs and mRNAs are found to play a crucial role in modulating different diseases including stroke, according to the recent evidence. The current study is aimed at assessing the functional role played by miR-188-5p in the regulation of cell apoptosis and viability in OGD-induced human neural cell line HNC. With the help of RT-qPCR, the authors determined miR-188-5p as well as its putative target PTEN among OGD-treated cells in different treatment times. The cell viability was assessed through CCK-8 assay while the cell transfection either upregulated or may have silenced the genes. Both Western Blot ...
Source: Experimental and Molecular Pathology - July 30, 2020 Category: Pathology Authors: Li L, Cui P, Ge H, Shi Y, Wu X, Ruan Z Tags: Exp Mol Pathol Source Type: research

LncRNA-ROR is involved in cerebral hypoxia/reoxygenation-induced injury via regulating miR-135a-5p/ROCK1/2.
In conclusion, this study indicated that LncRNA-ROR could promote the cerebral H/R injury by inhibiting the expression of miR-135a-5p through upregulating the expression of ROCK1/2. And, miR-135a-5p overexpression could improve the cerebral H/R injury by inhibiting the expression of ROCK1/2. PMID: 31419405 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - August 12, 2019 Category: Pathology Authors: Chen H, Li X Tags: Exp Mol Pathol Source Type: research

Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model.
Abstract Much evidence demonstrated that autophagy played an important role in neural inflammation response after ischemia stroke. However, the specific effect of microglia autophagy in cerebral ischemia is still unknown. In the current study, we constructed focal cerebral ischemia model by permanent middle cerebral artery occlusion (pMCAO) in mice. We detected microglia autophagy and inflammation response in vivo, and observed infarct brain areas, edema formation, and neurological deficits of mice. We found that pMCAO induced microglia autophagy and inflammatory response. The suppression of autophagy using either...
Source: Experimental and Molecular Pathology - February 6, 2015 Category: Pathology Authors: Yang Z, Zhong L, Zhong S, Xian R, Yuan B Tags: Exp Mol Pathol Source Type: research