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Status Epilepticus in Patients with SMART (P5.012)
CONCLUSIONS We describe three patients with SMART presenting with SE. Our cases raise the concern that SMART is not necessarily a migraine phenomenon but can be a form of focal SE associated with stroke-like symptoms. In patients with radiographic suspicion of SMART we suggest a low threshold for vEEG monitoring and aggressive anti-epileptic management.Disclosure: Dr. Fan has nothing to disclose. Dr. Gabriel has nothing to disclose. Dr. Gerard has nothing to disclose. Dr. Schuele has received personal compensation for activities with Sunovion and Eisai as a speaker.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Fan, P., Gabriel, H., Gerard, E., Schuele, S. Tags: Neuromuscular Disease and Epilepsy ePoster Session Source Type: research

Massive Epistaxis from Internal Carotid Pseudoaneurysm during Acute Ischemic Stroke in a Patient with Nasopharyngeal Carcinoma.
CONCLUSION: Carotid blowout syndrome in NPC patients during acute ischemic stroke warrants further cervical angiographic study. Endovascular treatment provides immediate hemostasis and obliteration of ICA pseudoaneurysm. PMID: 26077184 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Clinical Reasoning: A 66-year-old man with recurrent multi-territory infarcts
A 66-year-old man was referred to our center for evaluation of recurrent infarcts in multiple vascular territories over the preceding 6 months (figure 1). The patient first presented with a 3-month, stuttering course of transient neurologic deficits, including right arm and leg hemiparesis, expressive aphasia, and right homonymous hemianopia. He was initially evaluated at a community Stroke Prevention Clinic. His medical history was significant for several classic vascular risk factors: coronary artery disease requiring a coronary artery bypass graft, dyslipidemia for which he was taking atorvastatin 20 mg daily, and obstr...
Source: Neurology - June 8, 2015 Category: Neurology Authors: Kouzmitcheva, E., Steriade, C., Prica, A., Hazrati, L.-N., Mandell, D. M. Tags: All Cerebrovascular disease/Stroke, All Education RESIDENT AND FELLOW SECTION Source Type: research

Teaching NeuroImages: Radiation-associated symptomatic carotid artery disease with ipsilateral radiodermatitis
A 68-year-old man with a history of squamous cell carcinoma of the tongue treated with external beam radiation therapy in 2007 presented in 2013 with acute onset expressive aphasia and right lower facial weakness. MRI confirmed an acute infarct in the left frontal cortex. CT angiography revealed occlusion vs critical stenosis of the left internal carotid artery, new from 2007. Examination of the patient's neck revealed ipsilateral radiodermatitis (figure). Therapeutic neck irradiation has been associated with accelerated atheromatous disease, carotid artery stenosis, and increased risk of stroke.1,2 Ipsilateral radiodermat...
Source: Neurology - February 2, 2015 Category: Neurology Authors: Ehrlich, M. E., Gulvezan, T., Southerland, A. M. Tags: All Imaging, All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research

The Syndrome of Stroke-like Migraine Attacks After Radiation Therapy Associated With Prolonged Unresponsiveness in an Adult Patient
Conclusions: Reduced level of consciousness of such severity and duration as observed here has not previously been described in SMART syndrome. This report, however, suggests that an excellent prognosis can be expected even in cases of prolonged unresponsiveness. The pathogenic mechanisms of SMART syndrome remain unclear, but may involve pathways common to both migraine and epilepsy.
Source: The Neurologist - January 1, 2015 Category: Neurology Tags: Case Report/Case Series Source Type: research

A Case Series Of Non-Bacterial Thrombotic Endocarditis Associated With Gynecological Malignancies (P6.248)
Conclusions:NBTE is an important ischemic stroke mechanism. We have reported three cases where the underlying malignancy was gynecological (endometrial, ovarian, and cervical). In the first two cases, the malignancy was discovered during the investigations for the stroke mechanism, while the third had a known underlying malignancy. This series highlights the need to consider gynecological malignancies as an underlying cause of stroke in young women; and that the ischemic event can occur prior to the malignancy diagnosis.Disclosure: Dr. Schabas has nothing to disclose. Dr.Teal has received personal compensation for activiti...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Schabas, A., Teal, P., Yip, S., Mann, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Uncomon Cause Stroke: Thalamic Stroke As Initial Presentation Of Dunnigan Familial Partial Lipodystrophy (FPLD) (P6.264)
We report a laminopathy case with no history of MS suffering strokeREPORT/CASEA Woman of 40 years old came to the stroke unit because of tingling in her right arm with acute onset. She suffers miscarriage twice. Her familial history reports a pseudocushingoid facies in a sister, a brother, some paternal uncles and her small daughter. She had no history of hypertension or diabetes.Neurological and general examination found pseudocushingoid facies, faciotroncular obesity, hirsutism, muscular hyperthrophy on upper body but amyotrophy of the lower part, proeminentes venous, a little adiposus tissue, acanthosis migrans on the n...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Radji, F., Leca Radu, E., Dannepond, K., Nunes, M.-L. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

N-type calcium channel antibody-mediated paraneoplastic limbic encephalitis: A diagnostic challenge
Conclusion: This case highlights limbic encephalitis as an atypical presentation of neuroendocrine cancer. It also illustrates how treatment of the underlying cancer can reverse limbic encephalitis and Lambert–Eaton myasthenic syndrome in a neuroendocrine carcinoma patient even before the paraneoplastic panel becomes negative.
Source: Journal of the Neurological Sciences - January 27, 2014 Category: Neurology Authors: Carlos Kamiya-Matsuoka, David Blas-Boria, Michelle D. Williams, Pedro Garciarena, Sudhakar Tummala, Ivo W. Tremont-Lukats Tags: Original Articles Source Type: research

Carcinoma cells misuse the host tissue damage response to invade the brain
The metastatic colonization of the brain by carcinoma cells is still barely understood, in particular when considering interactions with the host tissue. The colonization comes with a substantial destruction of the surrounding host tissue. This leads to activation of damage responses by resident innate immune cells to protect, repair, and organize the wound healing, but may distract from tumoricidal actions. We recently demonstrated that microglia, innate immune cells of the CNS, assist carcinoma cell invasion. Here we report that this is a fatal side effect of a physiological damage response of the brain tissue. In a brai...
Source: Glia - July 5, 2013 Category: Neurology Authors: Han‐Ning Chuang, Denise van Rossum, Dirk Sieger, Laila Siam, Florian Klemm, Annalen Bleckmann, Michaela Bayerlová, Katja Farhat, Jörg Scheffel, Matthias Schulz, Faramarz Dehghani, Christine Stadelmann, Uwe‐Karsten Hanisch, Claudia Binder, Tobias Puk Tags: Original Article Source Type: research

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