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Two-year change in 18F-sodium fluoride uptake in the carotid arteries of healthy subjects and angina pectoris patients
Conclusions: Slightly higher NaF uptake in the angina group indicated more ongoing carotid microcalcification at both time points in patients than in healthy subjects. The 2-year changes were very small in both groups, albeit with a tendency of slight decreases among healthy controls, suggesting a more dynamic, waxing and waning, process in these compared to a slow, but more consistent, progression in angina patients despite statin therapy in half of these.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Piri, R., Lici, G., Riyahimanesh, P., Gerke, O., Alavi, A., Flemming Hoilund-Carlsen, P. Tags: Clinical Science Source Type: research

Quantifying microcalcification activity in the thoracic aorta
ConclusionsAMA is a simple, rapid and reproducible method of quantifying global18F-NaF uptake across the ascending aorta and aortic arch that correlates with cardiovascular risk scores.
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research

18 F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques
Conclusions18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.
Source: Journal of Nuclear Cardiology - June 25, 2018 Category: Nuclear Medicine Source Type: research

Correlation of noninvasive imaging of vulnerable carotid artery plaque using NaF and FDG PET/CT and black-blood MRI with cerebral ischemia on brain MRI
Conclusion] These preliminary results suggest that NaF uptake in carotid artery seems to correlate with cerebral ischemic changes.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Norikane, T., Yamamoto, Y., Maeda, Y., Okada, M., Nishiyama, Y. Tags: Cardiovascular Council YIA Symposium Source Type: research

Carotid artery atherosclerosis:plaque imaging in the personalized-medicine era
Conclusion: The evolution of atherosclerosis imaging and the emergence of new methods to measure atherosclerotic plaque vulnerability, particularly in the field of molecular imaging, have provided new insights into the pathophysiology of atherosclerosis and can be utilized in drug discovery and efficacy trials.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Gharavi, M., Saboury, B., Werner, T., Alavi, A. Tags: Educational Exhibits Source Type: research