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Sensors ‐based monitoring and treatment approaches for in‐stent restenosis
AbstractCardiovascular disease (CVD) can progressively narrow arteries due to plaque accumulation on the inner walls of the blood vessels, which results in an obstructed blood flow, leading to heart attack, stroke, and even death if the obstruction is severe. A popular treatment for the disease is to use an intravascular mechanical device called the stent to achieve an immediate restoration of blood flow. However, the physical stimulation induced by the stent expansion can cause inflammation of the vessel tissue. As one of the most common post-stenting complications, re-narrowing of the vessel is the main pathology that le...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 26, 2022 Category: Materials Science Authors: Ying Yi, Bo Wang, Changping Li Tags: REVIEW ARTICLE Source Type: research

Comparison of optical microscopy and optical coherence tomography as quality assurance methods for evaluating lubricious hydrophilic coatings surrounding catheter shafts
AbstractCardiac catheters are a vital tool in medicine due to their widespread use in many minimally invasive procedures. To aid in advancing the catheter within the patient's vasculature, many catheters are coated with a lubricious hydrophilic coating (HPC). Although HPCs benefit patients, their delamination during use is a serious safety concern. Adverse health effects associated with HPC delamination include pulmonary and myocardial embolism, embolic stroke, infarction, and death. In order to improve patient outcomes, more consistent manufacturing methods and improved quality assurance techniques are needed to evaluate ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 22, 2020 Category: Materials Science Authors: Alexander A. Oliver, Jonathan S. Stinson, Ashley Osborne, Catherine Taylor, Jeremy Goldman, Sean J. Kirkpatrick Tags: ORIGINAL RESEARCH REPORT Source Type: research

Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke
AbstractEndogenous neurogenesis in stroke is insufficient to replace the lost brain tissue, largely due to the lack of a proper biological structure to let new cells dwell in the damaged area. We hypothesized that scaffolds made of hyaluronic acid (HA) biomaterials (BM) could provide a suitable environment to home not only new neurons, but also vessels, glia and neurofilaments. Further, the addition of exogenous cells, such as adipose stem cells (ASC) could increase this effect. Athymic mice were randomly assigned to a one of four group: stroke alone, stroke and implantation of BM, stroke and implantation of BM with ASC, a...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 11, 2018 Category: Materials Science Authors: Leyre Sanchez ‐Rojas, Ulises Gómez‐Pinedo, María Soledad Benito‐Martin, Gonzalo León‐Espinosa, Fernando Rascón‐Ramirez, Cristina Lendinez, Cristina Martínez‐Ramos, Jorge Matías‐Guiu, Manuel Monleón Pradas, Juan A. Barcia Tags: Original Research Report Source Type: research

Development of next generation cardiovascular therapeutics through bio ‐assisted nanotechnology
Abstract Cardiovascular diseases (CVDs) rank, next to cancer and stroke, among the deadliest diseases in the world. Among the major CVDs, acute myocardial infarction is a life‐threatening disorder resulting from permanent damage to the left ventricular cardiac tissue. The major coronary arteries that supply blood to the functional left ventricle become blocked due to thrombotic plaque occlusion. During myocardial ischemia, oxidative stress and free radicals destroy healthy cardiomyocytes, smooth muscle cells, and endothelial cells, followed by degradation of the extracellular matrix, which results in ventricular wall‐t...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 26, 2017 Category: Materials Science Authors: Rajesh Lakshmanan, Nilanjana Maulik Tags: Review Article Source Type: research