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Helping to End Addiction Long-term Initiative, or NIH HEAL Initiative, and NINDS (National Institute of Neurological Disorders and Stroke) Early Phase Pain Investigation Clinical Network (EPPIC-Net) Provides Robust Infrastructure for Clinical Trials of Non-addictive Pain Therapeutics
We present EPPIC-Net's accomplishments since opening in Q4 of 2019. In its first year, EPPIC-Net established a robust infrastructure including a Clinical Coordinating Center, Data Coordinating Center, and 12 Specialized Clinical Centers across th e US, providing broad outreach to diverse pain populations.
Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Barbara Karp, Rebecca Hommer, Marlene Peters Lawrence, Jennifer H. Barnes, Clinton B. Wright Tags: Clinical Trials for Pain Research121 Source Type: research

NIH HEAL Initiative: National Institute of Neurological Disorders and Stroke Preclinical Program for Non-Addictive Pain Therapeutic Development
The National Institutes of Health Helping to End Addiction Long-term, or NIH HEAL Initiative aims to focus efforts on advancing scientific solutions to stem the opioid crisis, improving prevention and treatment of opioid misuse/addiction, and enhancing pain management. NINDS is charged with accelerating the discovery and development of new non-addictive pharmacologic and non-pharmacologic pain therapeutics as part of the HEAL Initiative. PSPP provides researchers from academia and industry, within the US and internationally, an efficient, rigorous, one-stop in vivo resource to screen and profile therapeutic candidates incl...
Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Sarah Woller, Smriti Iyengar Tags: 107 Source Type: research

The prevalence, characteristics and impact of chronic pain in people with muscular dystrophies: A systematic review and meta-analysis
Muscular dystrophies (MDs) are a heterogeneous group of genetic diseases that are among the most common forms of neuromuscular diseases (NMDs). Clinically, MDs manifest as progressive muscle weakness related to loss of mobility, agility and physical movements as a consequence of defects in genes responsible for muscle protein synthesis 14, 29. According to the National Institute of Neurological Disorders and Stroke (NINDS), there are nine major groups of MDs40: Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), Myotonic dystrophy (DM), Facioscapulohumeral muscular dystrophy (FSHD), Congenital muscular dyst...
Source: The Journal of Pain - April 29, 2021 Category: Materials Science Authors: Meihuan Huang, Nico Magni, David Rice Tags: Review Article Source Type: research

P2X4R contributes to central disinhibition via TNF- α/TNFR1/GABAaR pathway in post-stroke pain rats
Stroke is the leading cause of adult disability worldwide41. Central post-stroke pain (CPSP) is a chronic neuropathic pain, which is one of the most difficult sequelae of ischemic and hemorrhagic stroke11. This syndrome is characterized by spontaneous or an abnormal sensation secondary to noxious or non-noxious stimuli including spontaneous pain, hyperalgesia, and allodynia17, which localize at one of multiple sites in the somatosensory pathway27. Thalamus stroke is one of the major causes of neuropathic central pain.
Source: The Journal of Pain - March 4, 2021 Category: Materials Science Authors: Jiajie Lu, Xiaoning Guo, Manyun Yan, Xiaqing Yuan, Shujun Chen, Yiqing Wang, Juehua Zhu, Shicun Huang, Haitao Shen, Haiying Li, Qun Xue, Qi Fang, Jianqiang Ni, Lei Gan, Hongru Zhao, Haifeng Lu, Gang Chen Tags: Original Reports Source Type: research

Alleviation of mechanical allodynia by 14,15-EET in a central post-stroke pain model: possible role of allopregnanolone and δGABAAR
Central post-stroke pain (CPSP) is a neuropathic pain syndrome arising after lesion of the central nervous system (CNS) due to cerebrovascular insult. This syndrome is characterised by somatosensory abnormalities including spontaneous pain, hyperalgesia and allodynia, which localized to body areas corresponding to the injured brain region.2 These conditions are constant and could impair activities of daily living, consequently undermine quality of life and rehabilitation process. However, CPSP is probably the least recognized complication of stroke and the mechanism of which has not been adequately studied to date.
Source: The Journal of Pain - November 27, 2018 Category: Materials Science Authors: Xuhui Chen, Zuofan Li, Bo Zhang, Rong Hu, Jiayan Li, Miaomiao Feng, Wenlong Yao, Chuanhan Zhang, Li Wan, Yue Zhang Tags: Original Reports Source Type: research

Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors
Central poststroke pain (CPSP) is a neuropathic pain syndrome arising after a lesion of the central nervous system (CNS) owing to cerebrovascular insult. This syndrome is characterized by somatosensory abnormalities, including spontaneous pain, hyperalgesia, and allodynia, which localized to body areas corresponding to the injured brain region.2 These conditions are constant and could impair the activities of daily living, consequently undermine the quality of life and rehabilitation process. However, CPSP is probably the least-recognized complication of stroke and its mechanism has not been studied adequately to date.
Source: The Journal of Pain - November 27, 2018 Category: Materials Science Authors: Xuhui Chen, Zuofan Li, Bo Zhang, Rong Hu, Jiayan Li, Miaomiao Feng, Wenlong Yao, Chuanhan Zhang, Li Wan, Yue Zhang Tags: Original Reports Source Type: research

AAPT Diagnostic Criteria for Central Neuropathic Pain
Central neuropathic pain, which is pain caused by a lesion or disease of the central somatosensory nervous system, is a serious consequence of spinal cord injury, stroke, multiple sclerosis and other conditions affecting the central nervous system. A collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy (AAPT) initiative, invited a working group to develop diagnostic criteria for central neuropathic pain.
Source: The Journal of Pain - June 27, 2017 Category: Materials Science Authors: Eva Widerstrom-Noga, John D. Loeser, Troels Staehelin Jensen, Nanna Brix Finnerup Source Type: research

(376) Impact of the Harborview Chronic Pain Self-Management Program on participants ’ quality of life, confidence and pain experience
The Chronic Pain Self-Management Program (CPSMP) is as an evidenced-based model that helps sufferers of chronic pain conditions learn how to better manage their pain symptoms and overall health status. The CPSMP involves a six-week long workshop that is designed for adults with chronic pain conditions to work together and build off of each other ’s strengths and knowledge regarding pain management. The program is adapted from the well-researched Chronic Disease Self-Management Program developed at Stanford that followed more than 1000 people with heart disease, lung disease, stroke or arthritis in a three-year randomized...
Source: The Journal of Pain - March 29, 2017 Category: Materials Science Authors: D. Gordon, A. Meins, J. Noar, A. Doorenbos, D. Tauben, I. Lesnik Source Type: research

(412) Patient with altered mental status, an intrathecal pump, and an unknown dose of ziconotide
72 year old female with past medical history hypertension, CKD, depression, anxiety, remote history of delirium with psychosis during hospitalization, and chronic pain with intrathecal pump presented with altered mental status. Patient underwent CT head which did not show an acute stroke. Patient was treated for UTI early during her hospitalization without improvement in her confusion. An EEG did not show seizure activity or epileptiform discharges and an MRI did not show acute abnormalities. The primary team subsequently obtained a history of cognitive decline over the past 2-3 months that began shortly after the initiati...
Source: The Journal of Pain - March 31, 2016 Category: Materials Science Authors: K. Noon, T. Furnish Source Type: research

Repetitive Transcranial Magnetic Stimulation of the Left Premotor /Dorsolateral Prefrontal Cortex does not have Analgesic Effect on Central Post-Stroke Pain
Central post-stroke pain (CPSP) is caused by an encephalic vascular lesion of the somatosensory pathways and is commonly refractory to current pharmacological treatments. Repetitive transcranial magnetic stimulation (rTMS) of the premotor cortex/dorsolateral prefrontal cortex (PMC/DLPFC) can change thermal pain threshold towards analgesia in healthy subjects and has analgesic effects in acute post operatory pain as well as in fibromyalgia patients. However, its effect on neuropathic pain and in CPSP in particular, has not been assessed.
Source: The Journal of Pain - September 26, 2014 Category: Materials Science Authors: Rogério Adas Ayres de Oliveira, Daniel Ciampi de Andrade, Melina Mendonça, Rafael Barros, Tatiana Luvisoto, Martin Luiz Myczkowski, Marco Antonio Marcolin, Manoel Jacobsen Teixeira Source Type: research