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Specialty: Materials Science
Source: Biomaterials
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Total 35 results found since Jan 2013.
Improving outcomes in intracerebral hemorrhage through microglia/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes
Biomaterials. 2023 Aug 15;301:122277. doi: 10.1016/j.biomaterials.2023.122277. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) remains the most lethal type of stroke, and effective clinical therapies that can speed up hematoma resolution after ICH are still lacking. While the beneficial effects of IL-10 on ICH recovery have been demonstrated, the clinical translation of IL-10 requires effective delivery methods by which sufficient IL-10 can be delivered to ICH-affected regions in the brain. Here we report the use of a phosphatidylserine (PS) liposome (PSL)-based nanoparticle system for microglia/macrophage-tar...
Source: Biomaterials - August 19, 2023 Category: Materials Science Authors: Ranran Han Xi Lan Zheng Han Honglei Ren Safiya Aafreen Wenshen Wang Zhipeng Hou Tianyue Zhu Andrew Qian Xiaoning Han Raymond C Koehler Guanshu Liu Source Type: research
The potential role of the novel orodispersible film from rice polymer loaded with silkworm pupae hydrolysate and the combined extract of holy basil and ginger for the management of stroke with stress
In this study, we explored the neuroprotective effect of an orodispersible film derived from a rice polymer loaded with silkworm pupae and the combined extract of holy basil and ginger (JP1). Male Wistar rats weighing 200-250 g were administered JP1 at the doses of 1, 10, and 100 mg/kg BW 45 min prior to an exposure to a 6-h immobilization stress for 14 days. Permanent, occlusion of the right middle cerebral artery (MCAO) was performed, and JP1 was administered continually for 21 days after MCAO. Assessments of the brain infarction volume, oxidative stress, inflammation, and apoptosis in the cerebral cortex were carried ou...
Source: Biomaterials - June 1, 2023 Category: Materials Science Authors: Putthiwat Thongwong Jintanaporn Wattanathorn Wipawee Thukhammee Somsak Tiamkao Source Type: research
Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane
Biomaterials. 2022 Dec 23;293:121983. doi: 10.1016/j.biomaterials.2022.121983. Online ahead of print.ABSTRACTThe basement membrane (BM) of the blood-brain barrier (BBB), a thin extracellular matrix (ECM) sheet underneath the brain microvascular endothelial cells (BMECs), plays crucial roles in regulating the unique physiological barrier function of the BBB, which represents a major obstacle for brain drug delivery. Owing to the difficulty in mimicking the unique biophysical and chemical features of BM in in vitro systems, current in vitro BBB models have suffered from poor physiological relevance. Here, we describe a highl...
Source: Biomaterials - January 7, 2023 Category: Materials Science Authors: Jeong-Won Choi Jaeseung Youn Dong Sung Kim Tae-Eun Park Source Type: research
Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke
Biomaterials. 2022 Nov 10;291:121904. doi: 10.1016/j.biomaterials.2022.121904. Online ahead of print.ABSTRACTOxidative stress and mitochondrial damage are the main mechanisms of ischemia-reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free radical scavenging ability were used as carriers to load dl-3-n-butylphthalide (NBP-CeO2 NPs) for the combined treatment of ischemic stroke. NBP-CeO2 NPs could eliminate reactive oxygen species (ROS) in mouse brain microvascular endothelial cells and hippocampal neurons after oxygen-glucose deprivation/reoxygenation (OGD/R), and also save mitochond...
Source: Biomaterials - November 20, 2022 Category: Materials Science Authors: Xiang Li Zhihui Han Tianyi Wang Cheng Ma Haiying Li Huali Lei Yuqi Yang Yuanjie Wang Zifan Pei Zhuang Liu Liang Cheng Gang Chen Source Type: research
Crafting ɣ-L-Glutamyl-l-Cysteine layered Human Serum Albumin-nanoconstructs for brain targeted delivery of ropinirole to attenuate cerebral ischemia/reperfusion injury via "3A approach"
Biomaterials. 2022 Sep 15;289:121805. doi: 10.1016/j.biomaterials.2022.121805. Online ahead of print.ABSTRACTTreatment of Ischemic Stroke is inordinately challenging due to its complex aetiology and constraints in shuttling therapeutics across blood-brain barrier. Ropinirole hydrochloride (Rp), a propitious neuroprotectant with anti-oxidant, anti-inflammatory, and anti-apoptotic properties (3A) is repurposed for remedying ischemic stroke and reperfusion (I/R) injury. The drug's low bioavailability in brain however, limits its therapeutic efficacy. The current research work has reported sub-100 nm gamma-L-Glutamyl-L-Cystein...
Source: Biomaterials - September 26, 2022 Category: Materials Science Authors: Saman Fatima Mubashshir Ali Syed Naved Quadri Sarwar Beg M Samim Suhel Parvez Malik Zainul Abdin Prashant Mishra Farhan Jalees Ahmad Source Type: research
A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks
Biomaterials. 2022 Aug 15:121729. doi: 10.1016/j.biomaterials.2022.121729. Online ahead of print.ABSTRACTBrain arteriovenous malformations (AVMs) are a disorder wherein abnormal, enlarged blood vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one of the leading causes of hemorrhagic stroke in children and young adults. Most human sporadic brain AVMs are associated with genetic activating mutations in the KRAS gene. Our goal was to develop an in vitro model that would allow for simultaneous morphological and functional phenotypic data capture in real time during AVM disease progress...
Source: Biomaterials - August 23, 2022 Category: Materials Science Authors: Kayla Soon Mengyuan Li Ruilin Wu Angela Zhou Negar Khosraviani Williamson D Turner Joshua D Wythe Jason E Fish Sara S Nunes Source Type: research
Mapping the acute time course of immune cell infiltration into an ECM hydrogel in a rat model of stroke using < sup > 19 < /sup > F MRI
Biomaterials. 2022 Jan 25;282:121386. doi: 10.1016/j.biomaterials.2022.121386. Online ahead of print.ABSTRACTExtracellular matrix (ECM) hydrogel implantation into a stroke-induced tissue cavity invokes a robust cellular immune response. However, the spatio-temporal dynamics of immune cell infiltration into peri-infarct brain tissues versus the ECM-bioscaffold remain poorly understood. We here tagged peripheral immune cells using perfluorocarbon (PFC) nanoemulsions that afford their visualization by 19F magnetic resonance imaging (MRI). Prior to ECM hydrogel implantation, only blood vessels could be detected using 19F MRI. ...
Source: Biomaterials - January 30, 2022 Category: Materials Science Authors: Michel Modo Harmanvir Ghuman Reem Azar Ryan Krafty Stephen F Badylak T Kevin Hitchens Source Type: research
Human bone marrow-derived mesenchymal stem cells play a role as a vascular pericyte in the reconstruction of human BBB on the angiogenesis microfluidic chip
In this study, we established human BBB-like microvasculature on an angiogenesis microfluidic chip and analyzed the role of human pericytes (hPCs) and human astrocytes (hACs) on the architecture of human brain microvascular endothelial cells (hBMEC)-derived microvasculature on a chip. We found that human bone marrow mesenchymal stem cells (hBM-MSCs) play a role as perivascular pericytes in tight BBB reformation with a better vessel-constrictive capacity than that of hPCs, providing evidence of reparative stem cells on BBB repair rather than a paracrine effect. We also demonstrated that pericytes play an important role in v...
Source: Biomaterials - October 28, 2021 Category: Materials Science Authors: Sumin Kim Somin Lee Jungeun Lim Hyeri Choi Habin Kang Noo Li Jeon Youngsook Son Source Type: research
Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke
Biomaterials. 2021 Aug 31;277:121111. doi: 10.1016/j.biomaterials.2021.121111. Online ahead of print.ABSTRACTIschemic stroke leads to high disability and mortality. The limited delivery efficiency of most therapeutic substances is a major challenge for effective treatment of ischemic stroke. Inspired by the prominent merit of nanoscale particles in brain targeting and blood-brain barrier (BBB) penetration, various functional nanoparticles have been designed as promising drug delivery platforms that are expected to improve the therapeutic effect of ischemic stroke. Based on the complex pathological mechanisms of ischemic st...
Source: Biomaterials - September 6, 2021 Category: Materials Science Authors: Wenxiu He Zhiwen Zhang Xianyi Sha Source Type: research
