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Development of predictive algorithms for the wear resistance of denture teeth materials
CONCLUSIONS: 3D printed denture teeth materials showed the lowest wear out of all studied for 48 months simulation. LSTM model was successfully developed to predict wear of various denture teeth. The developed LSTM model has the potential to reduce simulation duration and specimen number for wear testing of various dental materials, while potentially improving the accuracy and reliability of wear testing predictions. This work paves the way for generalized multi-sample models enhanced with empirical information.PMID:37392604 | DOI:10.1016/j.jmbbm.2023.105984
Source: Journal of the Mechanical Behavior of Biomedical Materials - July 1, 2023 Category: Materials Science Authors: Anastasiia Grymak Mei Ting Tieh Alexander Hui Xiang Yang Joanne Jung Eun Choi Source Type: research

A new insight into the mechanical properties of nanobiofibers and vibrational behavior of atomic force microscope beam considering them as the samples
J Mech Behav Biomed Mater. 2023 Apr 5;142:105842. doi: 10.1016/j.jmbbm.2023.105842. Online ahead of print.ABSTRACTNowadays, the utilization and production of polymeric nanofibers are expanding rapidly due to their unique and exclusive properties. The current study examined silk fibroin nanofibers, poly-L lactic acid (PLLA), and polycaprolactone (PCL) as three widely-used biopolymers. In the first section, the mechanical properties of nanobiofibers, including elastic modulus as the first research variable, were investigated using atomic force microscopy (AFM)-based nanoindentation and tensile testing (through a universal te...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 9, 2023 Category: Materials Science Authors: Ali Jafari Ali Sadeghi Source Type: research

The influence of blood composition and loading frequency on the behavior of embolus analogs
J Mech Behav Biomed Mater. 2023 Feb 18;140:105738. doi: 10.1016/j.jmbbm.2023.105738. Online ahead of print.ABSTRACTIn cases of acute ischemic stroke (AIS), mechanical thrombectomy (MT) can be used to directly remove lodged thromboemboli. Despite improvements in patient outcomes, one of the key factors affecting MT success is the mechanical properties of the occlusive thrombus. Therefore, the goal of this study was to investigate the viscoelastic properties of embolus analogs (EAs) and determine the influence of EA hematocrit and loading frequency. Bovine blood EAs were created over a range of physiological hematocrits (0-6...
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 23, 2023 Category: Materials Science Authors: Bryan C Good Source Type: research

A low dimensional surrogate model for a fast estimation of strain in the thrombus during a thrombectomy procedure
CONCLUSIONS: The surrogate model provides nearly instantaneous estimates and constitutes a valuable tool for evaluating the risk of thrombus rupture during pre-operative planning for the treatment of acute ischemic stroke.PMID:36410165 | DOI:10.1016/j.jmbbm.2022.105577
Source: Journal of the Mechanical Behavior of Biomedical Materials - November 21, 2022 Category: Materials Science Authors: Sara Bridio Giulia Luraghi Francesco Migliavacca Sanjay Pant Alberto Garc ía-González Jose F Rodriguez Matas Source Type: research

Combined stent-retriever and aspiration intra-arterial thrombectomy performance for fragmentable blood clots: A proof-of-concept computational study
This study focuses on two aspects of the thrombectomy simulation: i) Thrombus fragmentation on the basis of a failure model calibrated with experimental tests on clot analogs; ii) the combined stent-retriever and aspiration catheter MT procedure is modeled by adding both the proximal balloon guide catheter and the distal access catheter. The adopted failure criterion is based on maximum principal stress threshold value. If elements of the thrombus exceed this criterion during the retrieval simulation, then they are deleted from the calculation. Comparison with in-vitro tests indicates that the simulation correctly reproduc...
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 18, 2022 Category: Materials Science Authors: Giulia Luraghi Sara Bridio Vittorio Lissoni Gabriele Dubini Anushree Dwivedi Ray McCarthy Behrooz Fereidoonnezhad Patrick McGarry Frank J H Gijsen Jose Felix Rodriguez Matas Francesco Migliavacca Source Type: research

Patient-specific biomechanical analysis of atherosclerotic plaques enabled by histologically validated tissue characterization from computed tomography angiography: A case study
CONCLUSION: Patient specific tissue characterization can identify distributions of stress and strain in a clinically relevant range. This capability may be used to identify high-risk lesions and personalize treatment decisions for individual patients with cardiovascular disease and improve prevention of myocardial infarction and stroke.PMID:36049368 | DOI:10.1016/j.jmbbm.2022.105403
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 1, 2022 Category: Materials Science Authors: Andrew J Buckler Max van Wanrooij M åns Andersson Eva Karl öf Ljubica Perisic Matic Ulf Hedin T Christian Gasser Source Type: research

Multicomponent material property characterization of atherosclerotic human carotid arteries through a Bayesian Optimization based inverse finite element approach
CONCLUSION: The developed iFEM approach combined with the inverted GP model successfully predicted component-wise material properties of intact atherosclerotic human carotids ex-vivo under physiological-like loading conditions.SIGNIFICANCE: We developed a novel iFEM framework for the nonlinear, component-wise material characterization of atherosclerotic arteries and utilized it to obtain human atherosclerotic carotid material properties. The developed iFEM framework has great potential to be advanced for patient-specific in-vivo application.PMID:34864574 | DOI:10.1016/j.jmbbm.2021.104996
Source: Journal of the Mechanical Behavior of Biomedical Materials - December 5, 2021 Category: Materials Science Authors: Su Guvenir Torun Hakki M Torun Hendrik H G Hansen Chris L de Korte Antonius F W van der Steen Frank J H Gijsen Ali C Akyildiz Source Type: research

Assessment of mechanical indicators of carotid plaque vulnerability: Geometrical curvature metric, plaque stresses and damage in tissue fibres.
Abstract Stroke is a major cause of death worldwide. The rupture of atherosclerotic carotid plaques is the leading single cause of stroke. Currently there is no accepted clinical measure to quantitatively assess the risk of carotid plaque rupture. Structural analyses of vulnerable plaques, using finite element (FE) analysis, have retrospectively found that regions of high stress tend to be the site of plaque rupture. The current study proposes a new clinical measure, based on plaque geometry, to assess the risk of carotid plaque rupture. This measure, named the weighted curvature difference, is based on the curvat...
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 25, 2020 Category: Materials Science Authors: Ghasemi M, Nolan DR, Lally C Tags: J Mech Behav Biomed Mater Source Type: research

Critical buckling pressure in mouse carotid arteries with altered elastic fibers.
This study provides experimental and theoretical methods for further investigating the influence of genetic mutations in elastic fibers on buckling behavior and the development of arterial tortuosity. PMID: 25771258 [PubMed - as supplied by publisher]
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 28, 2015 Category: Materials Science Authors: Luetkemeyer CM, James RH, Devarakonda ST, Le VP, Liu Q, Han HC, Wagenseil JE Tags: J Mech Behav Biomed Mater Source Type: research