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Is the optimal Tmax threshold identifying perfusion deficit volumes variable across MR perfusion software packages? A pilot study
ConclusionsThe optimal Tmax threshold for defining the ischemic penumbra appeared to be most accurate at  ≥ 6 s for package A and ≥ 10 s for package B. This implies that the widely recommended Tmax threshold ≥ 6 s may not be optimal for all available MRP software package. Future validation studies are required to define the optimal Tmax threshold to use for each package.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - February 22, 2023 Category: Materials Science Source Type: research

Combined acquisition of diffusion and T2*-weighted measurements using simultaneous multi-contrast magnetic resonance imaging
DiscussionThe simultaneous acquisition of multiple contrasts reduces the overall examination time and there is an inherent registration between contrasts. By using the results of this study to control saturation effects in SMC, the method enables rapid acquisition of distortion-matched and well-registered diffusion-weighted and T2*-weighted imaging, which could support rapid diagnosis and treatment of acute stroke.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 2, 2021 Category: Materials Science Source Type: research

CAFT: a deep learning-based comprehensive abdominal fat analysis tool for large cohort studies
ConclusionsDL-based, comprehensive SSAT, DSAT, and VAT analysis tool showed high accuracy and reproducibility and provided a comprehensive fat compartment composition analysis and visualization in less than 10  s.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - August 2, 2021 Category: Materials Science Source Type: research

Evaluation of atrial septal defects with 4D flow MRI —multilevel and inter-reader reproducibility for quantification of shunt severity
ConclusionBlood flow and shunt quantification measured at multiple levels and performed by different readers are reproducible and consistent with 4D flow MRI.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - August 31, 2018 Category: Materials Science Source Type: research

A comparative study of the sensitivity of diffusion-related parameters obtained from diffusion tensor imaging, diffusional kurtosis imaging, q-space analysis and bi-exponential modelling in the early disease course (24  h) of hyperacute (6 h) ischemic stroke patients
ConclusionOur comparison was performed using identical diffusion encoding timings and on patients in the same stage of their condition. Although preliminary, our findings confirm those of previous studies that showed enhanced sensitivity of kurtosis. A fine time mapping of diffusion metrics in hyperacute stroke patients was presented which advocates for further investigations on larger animal or human cohorts.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - March 5, 2017 Category: Materials Science Source Type: research

Magnetic resonance imaging detection of multiple ischemic injury produced in an adult rat model of minor stroke followed by mild transient cerebral ischemia
ConclusionWithin regions adjacent to an experimental minor stroke, a recurrence of a mild transient cerebral ischemia augmented T2 above increases produced by tMCAO alone, reflecting increased damage in this region. Exacerbation appeared broader with acute versus chronic recovery between insults.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - November 3, 2016 Category: Materials Science Source Type: research