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Fucoidan-functionalized polysaccharide submicroparticles loaded with alteplase for efficient targeted thrombolytic therapy
Biomaterials. 2021 Aug 30;277:121102. doi: 10.1016/j.biomaterials.2021.121102. Online ahead of print.ABSTRACTIntravenous administration of fibrinolytic drugs is the standard treatment of acute thrombotic diseases. However, current fibrinolytics exhibit limited clinical efficacy because of their short plasma half-lives and might trigger hemorrhagic transformations. Therefore, it is mandatory to develop innovative nanomedicine-based solutions for more efficient and safer thrombolysis with biocompatible and biodegradable thrombus-targeted nanocarrier. Herein, fucoidan-functionalized hydrogel polysaccharide submicroparticles w...
Source: Biomaterials - September 5, 2021 Category: Materials Science Authors: Alina Zenych Charl ène Jacqmarcq Rachida Aid Louise Fournier Laura M Forero Ramirez Fr édéric Chaubet Thomas Bonnard Denis Vivien Didier Letourneur C édric Chauvierre Source Type: research
