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The prevalence, characteristics and impact of chronic pain in people with muscular dystrophies: A systematic review and meta-analysis
Muscular dystrophies (MDs) are a heterogeneous group of genetic diseases that are among the most common forms of neuromuscular diseases (NMDs). Clinically, MDs manifest as progressive muscle weakness related to loss of mobility, agility and physical movements as a consequence of defects in genes responsible for muscle protein synthesis 14, 29. According to the National Institute of Neurological Disorders and Stroke (NINDS), there are nine major groups of MDs40: Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), Myotonic dystrophy (DM), Facioscapulohumeral muscular dystrophy (FSHD), Congenital muscular dyst...
Source: The Journal of Pain - April 29, 2021 Category: Materials Science Authors: Meihuan Huang, Nico Magni, David Rice Tags: Review Article Source Type: research

P2X4R contributes to central disinhibition via TNF- α/TNFR1/GABAaR pathway in post-stroke pain rats
Stroke is the leading cause of adult disability worldwide41. Central post-stroke pain (CPSP) is a chronic neuropathic pain, which is one of the most difficult sequelae of ischemic and hemorrhagic stroke11. This syndrome is characterized by spontaneous or an abnormal sensation secondary to noxious or non-noxious stimuli including spontaneous pain, hyperalgesia, and allodynia17, which localize at one of multiple sites in the somatosensory pathway27. Thalamus stroke is one of the major causes of neuropathic central pain.
Source: The Journal of Pain - March 4, 2021 Category: Materials Science Authors: Jiajie Lu, Xiaoning Guo, Manyun Yan, Xiaqing Yuan, Shujun Chen, Yiqing Wang, Juehua Zhu, Shicun Huang, Haitao Shen, Haiying Li, Qun Xue, Qi Fang, Jianqiang Ni, Lei Gan, Hongru Zhao, Haifeng Lu, Gang Chen Tags: Original Reports Source Type: research

(376) Impact of the Harborview Chronic Pain Self-Management Program on participants ’ quality of life, confidence and pain experience
The Chronic Pain Self-Management Program (CPSMP) is as an evidenced-based model that helps sufferers of chronic pain conditions learn how to better manage their pain symptoms and overall health status. The CPSMP involves a six-week long workshop that is designed for adults with chronic pain conditions to work together and build off of each other ’s strengths and knowledge regarding pain management. The program is adapted from the well-researched Chronic Disease Self-Management Program developed at Stanford that followed more than 1000 people with heart disease, lung disease, stroke or arthritis in a three-year randomized...
Source: The Journal of Pain - March 29, 2017 Category: Materials Science Authors: D. Gordon, A. Meins, J. Noar, A. Doorenbos, D. Tauben, I. Lesnik Source Type: research

(412) Patient with altered mental status, an intrathecal pump, and an unknown dose of ziconotide
72 year old female with past medical history hypertension, CKD, depression, anxiety, remote history of delirium with psychosis during hospitalization, and chronic pain with intrathecal pump presented with altered mental status. Patient underwent CT head which did not show an acute stroke. Patient was treated for UTI early during her hospitalization without improvement in her confusion. An EEG did not show seizure activity or epileptiform discharges and an MRI did not show acute abnormalities. The primary team subsequently obtained a history of cognitive decline over the past 2-3 months that began shortly after the initiati...
Source: The Journal of Pain - March 31, 2016 Category: Materials Science Authors: K. Noon, T. Furnish Source Type: research

Materials considerations of implantable neuroengineering devices for clinical use
Publication date: Available online 16 September 2014 Source:Current Opinion in Solid State and Materials Science Author(s): Daniel R. Merrill Implantable devices for recording and stimulation of the human nervous system offer promise for the treatment of disorders including spinal cord injury, stroke, traumatic brain injury, sensory and motor deficits, chronic pain, epilepsy, Parkinson’s disease and amputation. While advances in neuroengineering devices have been impressive, often the expectations and desires for a chronically implantable device remain unrealized. In the face of engineering approaches which perform wel...
Source: Current Opinion in Solid State and Materials Science - November 1, 2014 Category: Materials Science Source Type: research