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Heart valve surgery and the obesity paradox: A systematic review
SummaryObesity has been associated with increased incidence of comorbidities and shorter life expectancy, and it has generally been assumed that patients with obesity should have inferior outcomes after surgery. Previous literature has often demonstrated equivalent or even improved rates of mortality after cardiac surgery when compared to their lower-weight counterparts, coined the obesity paradox. Herein, we aim to review the literature investigating the impact of obesity on surgical valve interventions. PubMed and Embase were systematically searched for articles published from 1 January 2000 to 15 October 2021. A total o...
Source: Clinical Obesity - December 28, 2021 Category: Eating Disorders & Weight Management Authors: Ryaan EL ‐Andari, Sabin J. Bozso, Jimmy J. H. Kang, Alexandre M. A. Bedard, Corey Adams, Wei Wang, Jeevan Nagendran Tags: Review Article Source Type: research

Pharmacotherapy of obesity in complex diseases
SummaryMore than 40% of adults in the United States suffer from obesity. Obesity is inextricably linked to many chronic illnesses like type-2 diabetes mellitus, hypertension, hyperlipidemia, heart disease, sleep apnea, stroke, and cancers. When used in combination with lifestyle modifications, pharmacotherapy has a vital role in treating obesity and improves short-term and long-term outcomes. A growing number of physicians are now interested in obesity medicine, and many of them are seeking guidance on how to treat complex patients with co-morbidities. This review provides a practical guide to the use of anti-obesity medic...
Source: Clinical Obesity - December 13, 2021 Category: Eating Disorders & Weight Management Authors: Vishnu Priya Pulipati, Silvana Pannain Tags: Review Source Type: research

Are healthcare costs from obesity associated with body mass index, comorbidity or depression? Cohort study using electronic health records
The objective of this study was to evaluate the association between body mass index (BMI) and healthcare costs in relation to obesity‐related comorbidity and depression. A population‐based cohort study was undertaken in the UK Clinical Practice Research Datalink (CPRD). A stratified random sample was taken of participants registered with general practices in England in 2008 and 2013. Person time was classified by BMI category and morbidity status using first diagnosis of diabetes (T2DM), coronary heart disease (CHD), stroke or malignant neoplasms. Participants were classified annually as depressed or not depressed. Cos...
Source: Clinical Obesity - March 31, 2016 Category: Eating Disorders and Weight Management Authors: C. Rudisill, J. Charlton, H. P. Booth, M. C. Gulliford Tags: Original Article Source Type: research

Impact of metabolic disorders on the relation between overweight/obesity and incident myocardial infarction and ischaemic stroke in fertile women: a nationwide cohort study
ConclusionsThe risk of myocardial infarction and ischaemic stroke was more strongly associated with the presence of metabolic disorders than with overweight per se in fertile women. Targeting prevention of metabolic disorders might be beneficial to reduce cardiovascular disease in overweight/obese young women.
Source: Clinical Obesity - April 15, 2015 Category: Eating Disorders and Weight Management Authors: S. S. Andersen, C. Andersson, S. M. Berger, T. B. Jensen, C. T. Torp‐Pedersen, G. H. Gislason, L. Køber, M. D. Schmiegelow Tags: Original Article Source Type: research

The cost‐effectiveness of primary care referral to a UK commercial weight loss programme
This study investigated whether such a programme was cost‐effective compared with usual care. A decision‐analytical Markov model was developed to estimate the lifetime costs and benefits of the referral programme compared with usual care and enable a cost‐utility analysis. The model cohort transited between body mass index classifications and type 2 diabetes, stroke and myocardial infarction (MI) with risk, cost and effect parameter values taken from published literature. The cost per incremental quality‐adjusted life year (QALY) was calculated. Extensive deterministic and scenario sensitivity analyses and probabil...
Source: Clinical Obesity - November 19, 2014 Category: Eating Disorders and Weight Management Authors: D. M. Meads, C. T. Hulme, P. Hall, A. J. Hill Tags: Original Article Source Type: research