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Prostaglandin E2, 9S-, 13S-HODE and resolvin D1 are strongly associated with the post-stroke cognitive impairment
Publication date: Available online 10 June 2021Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Dariusz Kotlęga, Barbara Peda, Arleta Drozd, Agnieszka Zembroń-Łacny, Ewa Stachowska, Jarosław Gramacki, Małgorzata Szczuko
Source: Prostaglandins and Other Lipid Mediators - June 12, 2021 Category: Lipidology Source Type: research

Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases
Publication date: April 2020Source: Prostaglandins & Other Lipid Mediators, Volume 147Author(s): Jogen Atone, Karen Wagner, Kenji Hashimoto, Bruce D. HammockAbstractCytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects in inflammatory disorders. Endogenous EpFAs are further metabolized into corresponding diols by the soluble epoxide hydrolase (sEH). Through inhibition of sEH, many studies have demonstrated the cardioprotective and renoprotective effects of EpFAs; however, the role of sEH inhibition in...
Source: Prostaglandins and Other Lipid Mediators - December 6, 2019 Category: Lipidology Source Type: research

Prostaglandins and Other Lipid Mediators Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases
Publication date: Available online 5 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Jogen Atone, K Wagner, Kenji Hashimoto, Bruce HammockAbstractCytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects in inflammatory disorders. Endogenous EpFAs are further metabolized into corresponding diols by the soluble epoxide hydrolase (sEH). Through inhibition of sEH, many studies have demonstrated the cardioprotective and renoprotective effects of EpFAs; however, the role of sEH inhibition...
Source: Prostaglandins and Other Lipid Mediators - November 6, 2019 Category: Lipidology Source Type: research

Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids
Publication date: November 2018Source: Prostaglandins & Other Lipid Mediators, Volume 139Author(s): Reheman Adili, Megan Hawley, Michael HolinstatAbstractThrombosis is the most common underlying pathology responsible for morbidity and mortality in cardiovascular disease (CVD). Platelet adhesion, activation, and aggregation play central roles in hemostasis; however, the same process may also cause thrombosis and vessel occlusion at the site of ruptured atherosclerotic lesions leading to heart attack and stroke. ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) are an essential component of the platelet phospholipid membrane...
Source: Prostaglandins and Other Lipid Mediators - October 4, 2018 Category: Lipidology Source Type: research

Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke
Publication date: January 2016 Source:Prostaglandins & Other Lipid Mediators, Volume 122 Author(s): Hui Huang, Mohamed Al-Shabrawey, Mong-Heng Wang Arachidonic acid (AA) is metabolized by cyclooxygenase (COX) and cytochrome P450 (CYP) enzymes into eicosanoids, which are involved in cardiovascular diseases and stroke. Evidence has demonstrated the important functions of these eicosanoids in regulating cerebral vascular tone, cerebral blood flow, and autoregulation of cerebral circulation. Although COX-2 inhibitors have been suggested as potential treatments for stroke, adverse events, including an increased ris...
Source: Prostaglandins and Other Lipid Mediators - January 11, 2016 Category: Lipidology Source Type: research

Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: possible interaction with genes involved in 20-HETE and EETs metabolism
Conclusions Our data do not support a major role of ω-6 or ω-3 PUFA intakes on BP change over time, but suggest a possible interaction of ω-3 PUFA with the CYP4F2 V433M.
Source: Prostaglandins and Other Lipid Mediators - May 17, 2015 Category: Lipidology Source Type: research