Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases

Publication date: April 2020Source: Prostaglandins & Other Lipid Mediators, Volume 147Author(s): Jogen Atone, Karen Wagner, Kenji Hashimoto, Bruce D. HammockAbstractCytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects in inflammatory disorders. Endogenous EpFAs are further metabolized into corresponding diols by the soluble epoxide hydrolase (sEH). Through inhibition of sEH, many studies have demonstrated the cardioprotective and renoprotective effects of EpFAs; however, the role of sEH inhibition in modulating the pathogenesis of neuroinflammatory disorders is less well described. In this review, we discuss the current knowledge surrounding the effects of sEH inhibition and EpFA action in neuroinflammatory disorders such as Parkinson’s Disease (PD), stroke, depression, epilepsy, and Alzheimer’s Disease (AD), as well as the potential mechanisms that underlie the therapeutic effects of sEH inhibition.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research