Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases

Publication date: April 2020Source: Prostaglandins &Other Lipid Mediators, Volume 147Author(s): Jogen Atone, Karen Wagner, Kenji Hashimoto, Bruce D. HammockAbstractCytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects in inflammatory disorders. Endogenous EpFAs are further metabolized into corresponding diols by the soluble epoxide hydrolase (sEH). Through inhibition of sEH, many studies have demonstrated the cardioprotective and renoprotective effects of EpFAs; however, the role of sEH inhibition in modulating the pathogenesis of neuroinflammatory disorders is less well described. In this review, we discuss the current knowledge surrounding the effects of sEH inhibition and EpFA action in neuroinflammatory disorders such as Parkinson’s Disease (PD), stroke, depression, epilepsy, and Alzheimer’s Disease (AD), as well as the potential mechanisms that underlie the therapeutic effects of sEH inhibition.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research

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CONCLUSION: The effectiveness of behavioural activation in randomized controlled trials varied from small to large (d = 0.24-1.7) in reducing depression. The content of behavioural activation was comparable to established treatment manuals. Adaptations appeared to support individuals to engage in therapy. REVIEW REGISTRATION: PROSPERO 2018, CRD42018102604. PMID: 31875690 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - Category: Rehabilitation Authors: Tags: Clin Rehabil Source Type: research
ConclusionsAED use was common in nursing homes, with gabapentin most commonly used (presumably for pain). That multiple comorbidities were associated with AED use underscores the need for future studies to investigate the safety and effectiveness of AED use in nursing home residents.
Source: Drugs and Aging - Category: Geriatrics Source Type: research
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Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
Publication date: Available online 5 November 2019Source: Prostaglandins &Other Lipid MediatorsAuthor(s): Jogen Atone, K Wagner, Kenji Hashimoto, Bruce HammockAbstractCytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects in inflammatory disorders. Endogenous EpFAs are further metabolized into corresponding diols by the soluble epoxide hydrolase (sEH). Through inhibition of sEH, many studies have demonstrated the cardioprotective and renoprotective effects of EpFAs; however, the role of sEH inhibit...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
_____ F1’s McLaren Racing Extends Neurotechnology Partnership With MindMaze (SportTechie): “Formula 1 team McLaren Racing has signed a multi-year partnership with Swiss neurotechnology firm MindMaze to continue testing neurosensing technology on its drivers. MindMaze’s combination of virtual reality, motion capture and EEG brain scans has previously been used to assist stroke patients with recovery, and the company is also trying to develop a computer chip that can mimic the way the brain processes information. The company raised a $100 million funding round in 2016. McLaren originally partnered with the ...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Peak Performance Technology brain scans EEG EEG brain scans McLaren Racing MindDrive MindMaze motion capture neurosensing Neurotechnology United States Grand Prix virtual-reality Source Type: blogs
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Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
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Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Healthcare medicine Source Type: news
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Source: Journal of Innovative Optical Health Sciences - Category: Biomedical Science Authors: Source Type: research
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Source: Techniques in Orthopaedics - Category: Orthopaedics Tags: Symposium Source Type: research
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