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Specialty: Neurosurgery
Therapy: Statin Therapy

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Total 28 results found since Jan 2013.

Intracranial hemorrhage in large vessel occlusion patients receiving endovascular thrombectomy with or without intravenous alteplase: a secondary analysis of the DIRECT-MT trial
Conclusions Our data showed that in the DIRECT-MT trial, alteplase did not increase overall ICH for large vessel occlusion patients treated with thrombectomy, but it increased the parenchymal hematoma rate.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Hu, X., Zhou, Y., Ospel, J., Yao, F., Liu, Y., Wang, H., Li, B., Hui, P., Yang, P., Zhang, Y., Zhang, L., Li, Z., Xing, P., Shi, H., Han, H., Wang, S., Fang, Q., Liu, J., for the Direct-MT investigators Tags: Open access, Ischemic stroke Source Type: research

E-107 Carotid artery stenting in patients with symptomatic non-stenotic carotid artery disease - a case series
ConclusionsIn this case series performed over a 10-year period at a high-volume stroke center we show that CAS is safe and efficient in patients with SyNC. Previous studies have established safety and effectiveness of CES in patients presenting with SyNC, however there is a paucity of reports in the literature regarding the effect of CAS in this patient population. Recent guidelines have brought specific attention to high-risk plaque characteristics which suggest that plaque instability plays a major role in the onset of ischemic events, regardless of lumen narrowing. Advanced imaging techniques, such as Optical Coherence ...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Nedelcu, S., Kuhn, A., Singh, J., Puri, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-113 Lower low-density lipoprotein level increases the risk of delayed parenchymal hematoma following endovascular thrombectomy
ConclusionLDL level <50 mg/dL independently predicted delayed PH following thrombectomy and LDL >100 was shown to be a protective factor, irrespective of statin use. Further study is needed to explore the underlying mechanism and identify the strategies to prevent post-thrombectomy delayed PH among patients with low LDL levels.Disclosures S. Ahn: None. S. Roth: None. J. Jo: None. Y. Ko: None. N. Mummareddy: None. M. Fusco: None. R. Chitale: None. M. Froehler: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Ahn, S., Roth, S., Jo, J., Ko, Y., Mummareddy, N., Fusco, M., Chitale, R., Froehler, M. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-187 Pipeline embolization stent for treatment of giant supraclinoid aneurysms: a case series
ConclusionThe Pipeline embolization device is a novel technique that can be utilized for treatment of giant cerebrovascular aneurysms with emerging evidence of immediate and long-term success. Further patient enrollment and clinical trials will be required to assess its efficacy in comparison to other endovascular and surgical approaches for the treatment of giant aneurysms.Disclosures M. Fana: None. O. Alsrouji: None. M. Rehman: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Fana, M., Alsrouji, O., Rehman, M. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-238 A jellyfish in the net - a case of recurrent stroke caused by a mobile floating carotid intimal plaque
ConclusionMobile floating carotid intimal plaque is a rare cause of embolic events. While the carotid stenosis is not severe, a meticulous examination of carotid doppler sonography needed to find any embolic source.Disclosures S. Lee: None. Y. Won: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lee, S., Won, Y. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Prediction of death after endovascular thrombectomy in the extended window: a secondary analysis of DEFUSE 3 "
Conclusions Despite selective inclusion criteria and overwhelming benefit for EVT, a substantial number of EVT patients in DEFUSE 3 died. The preprocedural variables age, NIHSS, wake-up stroke, and diabetes may predict this risk. Our predictive score provides a basis for future research to determine which factors influence lethal outcome after EVT.
Source: Journal of NeuroInterventional Surgery - August 13, 2021 Category: Neurosurgery Authors: Taussky, P., Agnoletto, G., Grandhi, R., Alexander, M. D., Wong, K.-H., Albers, G. W., de Havenon, A. Tags: Ischemic stroke Source Type: research

The Protective Effects of Statins Towards Vessel Wall Injury Caused by a Stent Retrieving Mechanical Thrombectomy Device : A Histological Analysis of the Rabbit Carotid Artery Model
CONCLUSION: We presented that statin administration before and after MT exerted protective effects towards vessel wall injury. The efficacy of statins was greater post-administration than pre-administration. Thus, statin administration in routine prescriptions in the peri-procedural period is strongly advised.PMID:33985322 | DOI:10.3340/jkns.2020.0303
Source: Journal of Korean Neurosurgical Society - May 14, 2021 Category: Neurosurgery Authors: Seung Hwan Lee Hee Sup Shin Inho Oh Source Type: research

The impact of statin therapy after surgical or endovascular treatment of cerebral aneurysms.
CONCLUSIONSConsistent statin therapy was significantly associated with better prognosis after coil embolization or surgical clipping of cerebral aneurysms. PMID: 31125972 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - May 23, 2019 Category: Neurosurgery Authors: Song TJ, Oh SH, Kim J Tags: J Neurosurg Source Type: research

Stabilization of vulnerable carotid plaques with proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab
We describe three patients treated with PCSK9 inhibitor alirocumab for progressive carotid stenosis despite lipid-lowering statin therapy. All three patients had vulnerable plaques on magnetic resonance (MR) plaque imaging. After alirocumab treatment initiation, no patients suffered stroke or adverse events, and the stabilization of the carotid plaques was observed on MR plaque imaging.
Source: Acta Neurochirurgica - February 7, 2019 Category: Neurosurgery Source Type: research

In Reply to “Statin Use in Patients Undergoing Carotid Artery Endarterectomy May Significantly Reduce the Occurrence of 30-day Stroke and Myocardial Infarction”
We would like to thank Zheng et  al1 for their letter regarding our meta-analysis entitled “Outcome of Carotid Artery Endarterectomy in Statin Users versus Statin-Naïve Patients: A Systematic Review and Meta-Analysis.”2
Source: World Neurosurgery - September 20, 2018 Category: Neurosurgery Authors: Pavlos Texakalidis, Stefanos Giannopoulos, Damianos G. Kokkinidis, Pascal Jabbour, John Reavey-Cantwell, Leonardo Rangel-Castilla Tags: Letter to the Editor Source Type: research

Statin Use in Patients Undergoing Carotid Artery Endarterectomy May Significantly Reduce the Occurrence of 30-Day Stroke and Myocardial Infarction
With great interest, we read the article by Texakalidis et  al1 entitled “Outcome of Carotid Artery Endarterectomy in Statin Users versus Statin-Naïve Patients: A Systematic Review and Meta-Analysis” published in a recent issue of WORLD NEUROSURGERY. The authors performed a meta-analysis to determine whether the use of statins is beneficial in patient s undergoing carotid artery endarterectomy (CEA). The study is of profound academic importance, and there are some points we would like to address.
Source: World Neurosurgery - September 20, 2018 Category: Neurosurgery Authors: Feng Zheng, Chuanzhen Qiu, Shaochun Yang, Boris Krischek Tags: Letter to the Editor Source Type: research

Assessment of the MRI and Behavioral Test Results in a Focal Cerebral Ischemia-Reperfusion Model in the Rat after Separate and Combined Use of Mouse-Derived Neural Progenitor Cells, Human-Derived Neural Progenitor Cells and Atorvastatin.
CONCLUSION: Both hNPC and mNPC treatments significantly improved functional outcome, and reduced infarct area ratio after stroke. Atorvastatin enhanced the therapeutic potency of NPCs, including neurological improvement. PMID: 30192361 [PubMed - in process]
Source: Turkish Neurosurgery - September 9, 2018 Category: Neurosurgery Authors: Tahta A, Izgi N, Bagci-Onder T, Erdag E, Aras Y, Genc C Tags: Turk Neurosurg Source Type: research

Assessment of the MRI and Behavioral Test Results in Focal Cerebral Ischemia Reperfusion Model in Rat after Separate and Combined Use of Mouse-Derived Neural Progenitor Cells, Human-Derived Neural Progenitor Cells and Atorvastatin.
CONCLUSION: Both hNPC and mNPC treatments significantly improved functional outcome, and reduced infarct area rate after stroke. Atorvastatin enhanced the therapeutic potency of NPCs, including neurological improvement. PMID: 29204982 [PubMed - as supplied by publisher]
Source: Turkish Neurosurgery - November 1, 2017 Category: Neurosurgery Authors: Tahta A, Izgi N, Onder TB, Erdag E, Aras Y, Genc C Tags: Turk Neurosurg Source Type: research