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Specialty: Virology
Source: Antiviral Therapy
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Total 1 results found since Jan 2013.
Could pharmacological curtailment of the RhoA/Rho-kinase pathway reverse the endothelial barrier dysfunction associated with Ebola virus infection?
Publication date: February 2015 Source:Antiviral Research, Volume 114 Author(s): Shahram Eisa-Beygi , Xiao-Yan Wen Activation of the RhoA/Rho-kinase (ROCK) pathway induces endothelial barrier dysfunction and increased vascular permeability, which is a hallmark of various life-threatening vascular pathologies. Therapeutic approaches aimed at inhibiting the RhoA/ROCK pathway have proven effective in the attenuation of vascular leakage observed in animal models of endotoxin-induced lung injury/sepsis, edema, autoimmune disorders, and stroke. These findings suggest that treatments targeting the ROCK pathway might be of benef...
Source: Antiviral Therapy - January 2, 2015 Category: Virology Source Type: research
