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CYP2C19 Loss-of-Function Associated with First-Time Ischemic Stroke in Non-surgical Asymptomatic Carotid Artery Stenosis During Clopidogrel Therapy
This study measures effect ofCYP2C19 genotype on ischemic stroke risk during clopidogrel therapy for asymptomatic, extracranial carotid stenosis patients. Using deidentified electronic health records, patients were selected for retrospective cohort using administrative code for carotid stenosis, availability ofCYP2C19 genotype result, clopidogrel exposure, and established patient care. Patients with intracranial atherosclerosis, aneurysm, arteriovenous malformation, prior ischemic stroke, or observation time<1 month were excluded. Dual antiplatelet therapy patients were included. Patients with carotid endarterectomy or ...
Source: Translational Stroke Research - February 21, 2021 Category: Neurology Source Type: research

Stroke Prevention and Dementia: 15-year Follow-up of the Asymptomatic Carotid Surgery Trial-1 (ACST-1)
Introduction: Carotid endarterectomy (CEA) might protect against dementia by reducing future stroke risk and improving cerebral blood flow. Using linkage of randomised trial participants to electronic health records, we aimed to measure the long-term effect of CEA on stroke and on recorded dementia in ACST-1 (ISRCTN26156392).
Source: European Journal of Vascular and Endovascular Surgery - November 30, 2019 Category: Surgery Authors: Alison Halliday, Anders Gotts äter, Mary Sneade, William Whiteley, Rebecca Llewellyn-Bennett, Sarah Parish, Sarah Pendlebury, Richard Peto, Martin Björck, Richard Bulbulia, Hongchao Pan Source Type: research