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Neuroprotective Effect of Dexmedetomidine on Cerebral Ischemia-Reperfusion Injury in Rats
CONCLUSION: Dexmedetomidine has a dose-dependent protective effect on cerebral ischemic injury in rats. The neuroprotective effects of dexmedetomidine are achieved, in part, by reducing the oxidative stress response, inhibiting glial overactivation, and inhibiting expression levels of apoptosis-related proteins.PMID:37235497
Source: Alternative Therapies in Health and Medicine - May 26, 2023 Category: Complementary Medicine Authors: Jianhong Lyu Yang Zhou Min Zhang Lingling Tang Xudan Bao Zaijiao Sun Li Huang Liqin Zhao Source Type: research

Impact of occurrence of cardiac arrest in the donor on long ‐term outcomes of pediatric heart transplantation
ConclusionThe occurrence of donor cardiac arrest has no impact on long-term survival in pediatric heart transplant recipients.
Source: Journal of Cardiac Surgery - November 8, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Sandeep Sainathan, Sameh Said, Tamy Tsujimoto, Feng ‐Chang Lin, Leonardo Mullinari, Mahesh Sharma Tags: ORIGINAL ARTICLE Source Type: research

FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation
Autophagy. 2022 Sep 28:1-20. doi: 10.1080/15548627.2022.2116833. Online ahead of print.ABSTRACTProper termination of cell-death-induced neural inflammation is the premise of tissue repair in acute ischemic stroke (AIS). Macrophages scavenge cell corpses/debris and produce inflammatory mediators that orchestrate immune responses. Here, we report that FOXP3, the key immune-repressive transcription factor of Tregs, is conditionally expressed in macrophages in stroke lesion. FOXP3 ablation in macrophages results in detrimental stroke outcomes, emphasizing the beneficial role of FOXP3+ macrophages. FOXP3+ macrophages are distin...
Source: Autophagy - September 28, 2022 Category: Cytology Authors: Wei Cai Mengyan Hu Chunyi Li Ruizhen Wu Danli Lu Chichu Xie Wei Zhang Tiemei Li Shishi Shen Huipeng Huang Wei Qiu Quentin Liu Yan Lu Zhengqi Lu Source Type: research

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