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Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort.
CONCLUSIONS: In COPD the presence of physician-diagnosed GERD is associated with increased symptoms, poorer QOL and increased frequency of exacerbations at baseline and during follow-up. These associations are maintained after controlling for PPI use. The PPI-exacerbations association could result from confounding-by-indication. PMID: 24894541 [PubMed - indexed for MEDLINE]
Source: Respiratory Care - October 12, 2014 Category: Respiratory Medicine Authors: Martinez CH, Okajima Y, Murray S, Washko GR, Martinez FJ, Silverman EK, Lee JH, Regan EA, Crapo JD, Curtis JL, Hatabu H, Han MK, COPDGene Investigators Tags: Respir Res Source Type: research

Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort
Background: The coexistence of gastroesophageal reflux disease (GERD) and COPD has been recognized, but there has been no comprehensive evaluation of the impact of GERD on COPD-related health status and patient-centered outcomes. Methods: Cross-sectional and longitudinal study of 4,483 participants in the COPDGene cohort who met GOLD criteria for COPD. Physician-diagnosed GERD was ascertained by questionnaire. Clinical features, spirometry and imaging were compared between COPD subjects without versus with GERD. We evaluated the relationship between GERD and symptoms, exacerbations and markers of microaspiration in univari...
Source: Respiratory Research - June 3, 2014 Category: Respiratory Medicine Authors: Carlos MartinezYuka OkajimaSusan MurrayGeorge WashkoFernando MartinezEdwin SilvermanJin LeeElizabeth ReganJames CrapoJeffrey CurtisHiroto HatabuMeiLan Han Source Type: research

"Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort"
Background: The coexistence of gastroesophageal reflux disease (GERD) and COPD has been recognized, but there has been no comprehensive evaluation of the impact of GERD on COPD-related health status and patient-centered outcomes. Methods: Cross-sectional and longitudinal study of 4,483 participants in the COPDGene cohort who met GOLD criteria for COPD. Physician-diagnosed GERD was ascertained by questionnaire. Clinical features, spirometry and imaging were compared between COPD subjects without versus with GERD. We evaluated the relationship between GERD and symptoms, exacerbations and markers of microaspiration in univari...
Source: Respiratory Research - June 3, 2014 Category: Respiratory Medicine Authors: Carlos MartinezYuka OkajimaSusan MurrayGeorge WashkoFernando MartinezEdwin SilvermanJin LeeElizabeth ReganJames CrapoJeffrey CurtisHiroto HatabuMeiLan Han Source Type: research