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Intraluminal Cell Transplantation Prevents Growth and Rupture in a Model of Rupture-Prone Saccular Aneurysms Basic Sciences
Conclusions— Lack of smooth muscle cells in the aneurysm wall promotes wall degradation, aneurysm growth and rupture, even if the aneurysm is occluded by luminal thrombus. Transplantation of smooth muscle cells into the luminal thrombus can reduce this degenerative remodeling.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Marbacher, S., Frosen, J., Marjamaa, J., Anisimov, A., Honkanen, P., von Gunten, M., Abo-Ramadan, U., Hernesniemi, J., Niemela, M. Tags: Animal models of human disease, Arterial thrombosis, Other Vascular biology Basic Sciences Source Type: research

Loss of Mural Cells Leads to Wall Degeneration, Aneurysm Growth, and Eventual Rupture in a Rat Aneurysm Model Basic Sciences
Conclusions— In the presented experimental setting, complete loss of mural cells acts as a driving force for aneurysm growth and rupture. The findings suggest that aneurysms missing mural cells are incapable to organize a luminal thrombus, leading to recanalization, increased inflammatory reaction, severe wall degeneration, and eventual rupture.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Marbacher, S., Marjamaa, J., Bradacova, K., von Gunten, M., Honkanen, P., Abo-Ramadan, U., Hernesniemi, J., Niemela, M., Frosen, J. Tags: Basic Sciences Source Type: research