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Impact of Dual Antiplatelet Therapy on Outcomes Among Aspirin-Resistant Patients Following Coronary Artery Bypass Grafting
This study was designed to define the impact of dual antiplatelet therapy (dAPT) on clinical outcomes among aspirin-resistant patients who underwent coronary artery surgery. We randomly assigned 219 aspirin-resistant patients according to multiple electrode aggregometry to receive clopidogrel (75 mg) plus aspirin (300 mg) or aspirin-monotherapy (300 mg). The primary end point was a composite outcome of all-cause death, nonfatal myocardial infarction, stroke, or cardiovascular hospitalization assessed at 6 months postoperatively. The primary end point occurred in 6% of patients assigned to dAPT and 10% of patients rando...
Source: The American Journal of Cardiology - March 3, 2014 Category: Cardiology Authors: Hrvoje Gasparovic, Mate Petricevic, Tomislav Kopjar, Zeljko Djuric, Lucija Svetina, Bojan Biocina Tags: Coronary Artery Disease Source Type: research

Comparison of 30-Day and 5-Year Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients Aged ≤50 Years (the Coronary aRtery diseAse in younG adultS Study)
Data on the outcome of young patients after coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) are scarce. Data on 2,209 consecutive patients aged ≤50 years who underwent CABG or PCI were retrospectively collected from 15 European institutions. PCI and CABG had similar 30-day mortality rates (0.8% vs 1.4%, p = 0.27), late survival (at 5 years, 97.8% vs 94.9%, p = 0.082), and freedom from stroke (at 5 years, 98.0% and 98.0%, p = 0.731). PCI was associated with significantly lower freedom from major adverse cardiac and cerebrovascular events (at 5 years, 73.9% vs 85.0%, p
Source: The American Journal of Cardiology - May 5, 2014 Category: Cardiology Authors: Fausto Biancari, Tomas Gudbjartsson, Jouni Heikkinen, Vesa Anttila, Timo Mäkikallio, Anders Jeppsson, Linda Thimour-Bergström, Carmelo Mignosa, Antonino S. Rubino, Kari Kuttila, Jarmo Gunn, Jan-Ola Wistbacka, Kari Teittinen, Kari Korpilahti, Francesco O Tags: Coronary Artery Disease Source Type: research

Comparison of Hybrid Coronary Revascularization Versus Coronary Artery Bypass Grafting in Patients ≥65 Years With Multivessel Coronary Artery Disease
In this study, patients aged ≥65 years were included who underwent HCR at an academic center from October 2003 to September 2013. These patients were matched 1:4 to similar patients treated with coronary artery bypass grafting (CABG) using a propensity-score matching algorithm. Conditional logistic regression and Cox regression stratified on matched pairs were performed to evaluate the association between HCR and CABG, and 30-day major adverse cardiovascular and cerebrovascular events (a composite of mortality, myocardial infarction, and stroke), periprocedural complications, and 3-year all-cause mortality. Of 715 patien...
Source: The American Journal of Cardiology - May 5, 2014 Category: Cardiology Authors: Ralf E. Harskamp, John D. Puskas, Jan G. Tijssen, Patrick F. Walker, Henry A. Liberman, Renato D. Lopes, Thomas A. Vassiliades, Eric D. Peterson, Michael E. Halkos Tags: Coronary Artery Disease Source Type: research

OP-055 Twelve Year Followup for Managing Coronary Artery Disease Using a Nutrigenomics Based Diet and Supplement Program and Quarterly Assessment of Biomarkers
Coronary Artery Disease (CAD) is thought to be progressive; standard treatment protocols call for instituting/instructing a low fat/low cholesterol diet program, exercise, and lipid lowering agents in an effort to slow the onset of recurrent MI's, stents, CABG's, stroke, or death. This results in an approximate 30-40% new event rate in 5 yrs.
Source: The American Journal of Cardiology - March 12, 2015 Category: Cardiology Authors: Steven Robert Gundry, Jean Epstein Tags: Oral Abstract Source Type: research

Comparison of Five-year Outcome of Percutaneous Coronary Intervention to Coronary Artery Bypass Grafting in Triple Vessel Coronary Artery Disease (From CREDO-Kyoto PCI/CABG Registry Cohort-2)
Studies evaluating long-term (>=5-year) outcomes of percutaneous coronary intervention (PCI) using drug-eluting stents compared with coronary artery bypass grafting (CABG) in patients with triple vessel coronary artery disease (TVD) are still limited. We identified 2978 patients with TVD (PCI: N=1824, CABG: N=1154) among 15939 patients with first coronary revascularization enrolled in the CREDO-Kyoto PCI/CABG registry cohort-2. The primary outcome measure in the current analysis was a composite of death, myocardial infarction (MI), and stroke.
Source: The American Journal of Cardiology - April 6, 2015 Category: Cardiology Authors: Hiroki Shiomi, Takeshi Morimoto, Yutaka Furukawa, Yoshihisa Nakagawa, Junichi Tazaki, Ryuzo Sakata, Hitoshi Okabayashi, Michiya Hanyu, Mitsuomi Shimamoto, Noboru Nishiwaki, Tatsuhiko Komiya, Takeshi Kimura, CREDO-Kyoto PCI/ CABG registry cohort-2 investig Source Type: research

Comparison of Five-Year Outcome of Percutaneous Coronary Intervention With Coronary Artery Bypass Grafting in Triple-Vessel Coronary Artery Disease (from the Coronary Revascularization Demonstrating Outcome Study in Kyoto PCI/CABG Registry Cohort-2)
Studies evaluating long-term (≥5 years) outcomes of percutaneous coronary intervention (PCI) using drug-eluting stents compared with coronary artery bypass grafting (CABG) in patients with triple-vessel coronary artery disease (TVD) are still limited. We identified 2,978 patients with TVD (PCI: n = 1,824, CABG: n = 1,154) of 15,939 patients with first coronary revascularization enrolled in the Coronary Revascularization Demonstrating Outcome Study in Kyoto PCI/CABG Registry Cohort-2. The primary outcome measure in the present analysis was a composite of death, myocardial infarction (MI), and stroke.
Source: The American Journal of Cardiology - April 6, 2015 Category: Cardiology Authors: Hiroki Shiomi, Takeshi Morimoto, Yutaka Furukawa, Yoshihisa Nakagawa, Junichi Tazaki, Ryuzo Sakata, Hitoshi Okabayashi, Michiya Hanyu, Mitsuomi Shimamoto, Noboru Nishiwaki, Tatsuhiko Komiya, Takeshi Kimura, the CREDO-Kyoto PCI/ CABG Registry Cohort-2 Inve Tags: Coronary Artery Disease Source Type: research

Coronary Artery Bypass Grafting Versus Drug-Eluting Stents Implantation for Prior Myocardial Infarction
Patients with prior myocardial infarction (MI) have a high risk of recurrence. Little is known about the effectiveness of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) with drug-eluting stents (DES) in patients with a prior MI and left main or multivessel coronary artery disease (CAD). We compared long-term outcomes of these two strategies in 672 patients with prior MI and left main or multivessel CAD, who underwent CABG (n=349) or PCI with DES (n=323). A pooled database from the BEST, PRECOMBAT, and SYNTAX trials was analyzed, and the primary outcome was a composite of death from a...
Source: The American Journal of Cardiology - April 19, 2016 Category: Cardiology Authors: Mineok Chang, Cheol Whan Lee, Jung-Min Ahn, Rafael Cavalcante, Yohei Sotomi, Yoshinobu Onuma, Yaping Zeng, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Patrick W. Serruys, Seung-Jung Park Source Type: research

Comparison of Outcome of Coronary Artery Bypass Grafting versus Drug-Eluting Stent Implantation for Non-ST-Elevation Acute Coronary Syndrome
There is limited data comparing effectiveness of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) with drug-eluting stents (DES) in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). We compared the long-term outcomes of the two revascularization strategies in 1,246 patients presented with NSTE-ACS for left main or multivessel coronary artery disease (CAD). Data were pooled from the BEST, PRECOMBAT, and SYNTAX trials. The primary outcome was a composite of death from any causes, myocardial infarction, or stroke.
Source: The American Journal of Cardiology - May 10, 2017 Category: Cardiology Authors: Mineok Chang, Cheol Whan Lee, Jung-Min Ahn, Rafael Cavalcante, Yohei Sotomi, Yoshinobu Onuma, Minkyu Han, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Patrick W. Serruys, Seung-Jung Park Source Type: research

Effect of Preoperative β-Blocker Use on Outcomes Following Cardiac Surgery
Recent studies suggest that the use of preoperative β-blockers in cardiac surgery may not provide improved mortality rates, and may even contribute to negative clinical outcomes. We therefore assessed the role of β-blockers on several outcomes following cardiac surgery (delirium, acute kidney injury (AKI), stroke, atrial fibrillation, mortality, an d hospital length of stay (LOS)) in 4,076 patients who underwent elective coronary artery bypass grafting, coronary artery bypass grafting + valve, or valve cardiac surgery between November 1, 2009 to September 30, 2015 at Vanderbilt Medical Center.
Source: The American Journal of Cardiology - July 24, 2017 Category: Cardiology Authors: Jason B. O'Neal, Frederic T. Billings, Xulei Liu, Matthew S. Shotwell, Yafen Liang, Ashish S. Shah, Jesse M. Ehrenfeld, Jonathan P. Wanderer, Andrew D. Shaw Source Type: research

Meta-Analysis of Comparison of Five-Year Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients with Unprotected Left Main Coronary Artery in the Era of Drug Eluting Stents
Patients with unprotected left main coronary artery (ULMCA) disease are increasingly being treated with percutaneous coronary intervention (PCI) using drug-eluting stents (DES), but long term outcomes comparing PCI with coronary artery bypass grafting (CABG) remain limited. We performed aggregate data meta-analyses of clinical outcomes [all cause death; non-fatal myocardial infarction (MI); stroke; repeat revascularization; cardiac death and major adverse cardiac and cerebrovascular events (MACCE)] in studies comparing 5 year outcomes of PCI with DES vs.
Source: The American Journal of Cardiology - August 1, 2017 Category: Cardiology Authors: Mahin R. Khan, Waleed T. Kayani, Waqas Ahmad, Ravi S. Hira, Salim S. Virani, Ihab Hamzeh, Hani Jneid, Nasser Lakkis, Mahboob Alam Source Type: research

Effect of Preoperative Beta-Blocker Use on Outcomes Following Cardiac Surgery
Recent studies suggest that the use of preoperative β blockers in cardiac surgery may not provide improved mortality rates and may even contribute to negative clinical outcomes. We therefore assessed the role of β blockers on several outcomes after cardiac surgery (delirium, acute kidney injury [AKI], stroke, atrial fibrillation (AF), mortality, an d hospital length of stay) in 4,076 patients who underwent elective coronary artery bypass grafting, coronary artery bypass grafting + valve, or valve cardiac surgery from November 1, 2009, to September 30, 2015, at Vanderbilt Medical Center.
Source: The American Journal of Cardiology - July 24, 2017 Category: Cardiology Authors: Jason B. O'Neal, Frederic T. Billings, Xulei Liu, Matthew S. Shotwell, Yafen Liang, Ashish S. Shah, Jesse M. Ehrenfeld, Jonathan P. Wanderer, Andrew D. Shaw Source Type: research

Meta-Analysis of Comparison of 5-Year Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Unprotected Left Main Coronary Artery in the Era of Drug-eluting Stents
Patients with unprotected left main coronary artery (ULMCA) disease are increasingly being treated with percutaneous coronary intervention (PCI) using drug-eluting stents (DES), but long-term outcomes comparing PCI with coronary artery bypass grafting (CABG) remain limited. We performed aggregate data meta-analyses of clinical outcomes (all-cause death, nonfatal myocardial infarction, stroke, repeat revascularization, cardiac death, and major adverse cardiac and cerebrovascular events) in studies comparing 5-year outcomes of PCI with DES versus CABG in patients with ULMCA disease.
Source: The American Journal of Cardiology - August 1, 2017 Category: Cardiology Authors: Mahin R. Khan, Waleed T. Kayani, Waqas Ahmad, Ravi S. Hira, Salim S. Virani, Ihab Hamzeh, Hani Jneid, Nasser Lakkis, Mahboob Alam Source Type: research

Meta-Analysis comparing Outcomes of Drug Eluting Stents versus Single and Multi-Arterial Coronary Artery Bypass Grafting
Relative benefits of coronary artery bypass (CABG) using single and multiple arterial grafting (SAG, MAG) and drug eluting stent (DES) in multivessel coronary disease remain uncertain. We compared SAG, MAG and DES in a pairwise and network meta-analysis. Randomized trials and adjusted observational studies comparing CABG versus DES were included (primary endpoint: long-term mortality; secondary endpoints: operative mortality, perioperative stroke and follow-up repeated revascularization [RR]). Studies with ≥1.7arterial grafts/patient were classified as MAG.
Source: The American Journal of Cardiology - September 13, 2018 Category: Cardiology Authors: Mario Gaudino, Mohamed Rahouma, Ahmed Abouarab, Derrick Y Tam, Antonino Di Franco, Jeremy Leonard, Umberto Benedetto, Mario Iannaccone, Fabrizio D'Ascenzo, Giuseppe Biondi-Zoccai, Michael Vallely, Leonard N Girardi, Stephen E Fremes, David P Taggart Source Type: research

Meta-Analysis Comparing Outcomes of Drug Eluting Stents Versus Single and Multiarterial Coronary Artery Bypass Grafting
Relative benefits of coronary artery bypass (CABG) using single and multiple arterial grafting (SAG, MAG) and drug eluting stent (DES) in multivessel coronary disease remain uncertain. We compared SAG, MAG, and DES in a pairwise and network meta-analysis. Randomized trials and adjusted observational studies comparing CABG versus DES were included (primary end point: long-term mortality; secondary end points: operative mortality, perioperative stroke, and follow-up repeated revascularization [RR]).
Source: The American Journal of Cardiology - September 13, 2018 Category: Cardiology Authors: Mario Gaudino, Mohamed Rahouma, Ahmed Abouarab, Derrick Y Tam, Antonino Di Franco, Jeremy Leonard, Umberto Benedetto, Mario Iannaccone, Fabrizio D'Ascenzo, Giuseppe Biondi-Zoccai, Michael Vallely, Leonard N Girardi, Stephen E Fremes, David P Taggart Source Type: research

Characteristics and Outcome of Patients ≥75 Years of Age with Prior Coronary Artery Bypass Grafting Admitted for an Acute Coronary Syndrome
The prognostic role of prior coronary artery bypass (CABG) in elderly patients admitted to hospital for an acute coronary syndrome (ACS) is unclear. Therefore, the aim of this study was to compare the prognosis of patients aged ≥75 years admitted for an ACS with or without prior history of CABG. The primary outcome of the study was a composite of overall mortality, recurrent non-fatal myocardial infarction (MI), non-fatal stroke and re-hospitalization for heart failure at 1-year follow-up. We included 2253 ACS patients, aged 81 (78-85) years enrolled in three multicentre studies (the Italian Elderly ACS study, the LADIES...
Source: The American Journal of Cardiology - April 1, 2020 Category: Cardiology Authors: Nuccia Morici, Roberta De Rosa, Gabriele Crimi, Leonardo De Luca, Luca A. Ferri, Laura Lenatti, Luigi Piatti, Giovanni Tortorella, Daniele Grosseto, Nicoletta Franco, Irene Bossi, Claudio Montalto, Roberto Antonicelli, Gianfranco Alicandro, Giuseppe De Lu Source Type: research

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