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Targeting oxidative stress, a crucial challenge in renal transplantation outcome
Free Radic Biol Med. 2021 Apr 20:S0891-5849(21)00258-6. doi: 10.1016/j.freeradbiomed.2021.04.023. Online ahead of print.ABSTRACTDisorders characterized by ischemia/reperfusion (I/R) are the most common causes of debilitating diseases and death in stroke, cardiovascular ischemia, acute kidney injury or organ transplantation. In the latter example the I/R step defines both the amplitude of the damages to the graft and the functional recovery outcome. During transplantation the kidney is subjected to blood flow arrest followed by a sudden increase in oxygen supply at the time of reperfusion. This essential clinical protocol c...
Source: Free Radical Biology and Medicine - April 23, 2021 Category: Biology Authors: Carcy Romain Cougnon Marc Poet Mallorie Durandy Manon Sicard Antoine Counillon Laurent Blondeau Nicolas Hauet Thierry Tauc Michel Pisani Didier F Source Type: research