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Stroke survivor attitudes toward, and motivations for, considering experimental stem cell treatments.
CONCLUSIONS: Stroke survivors may consider undergoing experimental stem cell treatments despite uncertainty regarding the risks/benefits. Clinicians should be mindful of the factors that may increase the likelihood of patients considering these treatments and intervene, where appropriate, to clarify any misconceptions regarding the medical/financial risks. IMPLICATION FOR REHABILITATION Stem cell treatments offer a new focus for reducing stroke-related disability, although their safety and effectiveness have yet to be established. Despite uncertainty regarding the medical risks and benefits associated with stem cell inject...
Source: Disability and Rehabilitation - February 1, 2019 Category: Rehabilitation Authors: Unsworth DJ, Mathias JL, Dorstyn DS, Koblar SA Tags: Disabil Rehabil Source Type: research

A Review of Stem Cell Therapy for Acquired Brain Injuries and Neurodegenerative Central Nervous System Diseases
Publication date: September 2018Source: PM&R, Volume 10, Issue 9, Supplement 2Author(s): Thomas K. WatanabeAbstractCell-based therapies have been the subject of much discussion regarding their potential role in enhancing central nervous system function for a number of pathologic conditions. Much of the current research has been in preclinical trials, with clinical trials in the phase I or I/II stage. Nevertheless, there is considerable interest in the public about the potential regenerative role that stem cells may have in improving function for these neurologic conditions. This review will describe the different types of ...
Source: PMandR - October 5, 2018 Category: Rehabilitation Source Type: research

Improvement in Motor Function Following Intracranial Implantation of Modified Bone Marrow Mesenchymal Stem Cells (SB623) for Chronic Ischemic Stroke
To determine if intracranial implantation of SB623 cells can improve chronic motor deficits caused by ischemic stroke.
Source: Archives of Physical Medicine and Rehabilitation - November 23, 2016 Category: Rehabilitation Authors: Gary Steinberg, Damien Bates, Wenzhong Jerry Liu, Douglas Kondziolka, Lawrence Wechsler, L. Dade Lunsford, Anthony S. Kim, Jeremiah N. Johnson, Neil E. Schwartz Tags: Research poster Source Type: research

Preliminary Safety of Intracranial Implantation of Modified Bone Marrow Mesenchymal Stem Cells (SB623) in Stroke Patients: A Phase 1/2A Study
To assess the safety of intracranial implantation of SB623 cells by stereotactic surgery.
Source: Archives of Physical Medicine and Rehabilitation - November 23, 2016 Category: Rehabilitation Authors: Gary Steinberg, Wenzhong Jerry Liu, Damien Bates, Douglas Kondziolka, Lawrence Wechsler, L. Dade Lunsford, Anthony S. Kim, Jeremiah N. Johnson, Neil E. Schwartz Tags: Oral research presentation Source Type: research

Stem cells and motor recovery after stroke
Publication date: Available online 28 August 2014 Source:Annals of Physical and Rehabilitation Medicine Author(s): I. Loubinoux , B. Demain , C. Davoust , B. Plas , L. Vaysse In stroke patients with severe persistent neurological deficits, alternative therapeutic modalities are limited. Stem cell therapy might be an opportunity when the safety profile of this approach will be achieved. This review will give possible mechanisms of restoration of function in animals and a statement of clinical trials in humans. The sources of neural stem cells for therapeutic use will be detailed. Potentials mechanisms of transplanted cell...
Source: Annals of Physical and Rehabilitation Medicine - October 12, 2014 Category: Rehabilitation Source Type: research