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Role of the continuous infusion test with an external pump for intrathecal baclofen in post-stroke spastic ambulatory patients
Discussion – conclusion Our pilot study showed that the continuous infusion test might be useful in order to evaluate the effect of different ITB doses in walking ability, helping the prediction of the appropriate candidates for ITB implantation.
Source: Annals of Physical and Rehabilitation Medicine - September 27, 2017 Category: Rehabilitation Source Type: research

Long-term Dosing of Intrathecal Baclofen in the Treatment of Spasticity after Acquired Brain Injury
Conclusion Despite the long-term use of ITB therapy in this cohort, the mean daily dose of intrathecal baclofen continued to require adjustments. There was no significant difference in the mean daily dose between patients with a diagnosis of TBI, stroke, or HIE. A complex dosing pattern was used more frequently in patients with stroke.
Source: PMandR - January 7, 2017 Category: Rehabilitation Source Type: research

Adherence Associated With Oral Medications in the Treatment of Spasticity
Objective: To examine adherence to baclofen, tizanidine, and dantrolene (U.S. Food and Drug Administration–approved oral spasticity medications), and identified determinants of adherence.Design: A retrospective administrative claims data analysis that used medical and pharmacy claims data and enrollment information from a large, national U.S. health plan.Subjects and Methods: The subjects were commercial health plan members who initiated treatment on baclofen, tizanidine, or dantrolene from January 1, 2004, through September 30, 2009, and who had stroke, spinal cord injury, traumatic brain injury, cerebral palsy, or mult...
Source: PM and R - May 6, 2013 Category: Rehabilitation Authors: Rachel Halpern, Patrick Gillard, Glenn D. Graham, Sepideh F. Varon, Richard D. Zorowitz Tags: Original Research Source Type: research

Intrathecal versus Oral Baclofen; a Matched Cohort Study of Spasticity, Pain, Sleep, Fatigue and Quality of Life
Conclusions Long-term treatment with intrathecal compared to oral baclofen is associated with reduced spasm frequency and severity as well as greater dose stability. These benefits must be weighted against the risks of internal pump and catheter placement in patients considering intrathecal baclofen therapy.
Source: PMandR - October 21, 2015 Category: Rehabilitation Source Type: research

Intrathecal Versus Oral Baclofen: A Matched Cohort Study of Spasticity, Pain, Sleep, Fatigue, and Quality of Life
Conclusions Long-term treatment with intrathecal compared with oral baclofen is associated with reduced spasm frequency and severity as well as greater dose stability. These benefits must be weighed against the risks of internal pump and catheter placement in patients considering intrathecal baclofen therapy.
Source: PMandR - November 22, 2015 Category: Rehabilitation Source Type: research

Poster 462: Efficacy of Intrathecal Baclofen Therapy Compared to Conventional Oral Treatment in Post-Stroke Spasticity: An International Multicenter Randomized Controlled Trial (SISTERS)
Michael Creamer: I Have No Relevant Financial Relationships To Disclose
Source: PM and R - September 1, 2017 Category: Rehabilitation Authors: Michael J. Creamer, Geoffrey C. Cloud, Peter PK. Kossmehl, Michael R. Yochelson, Gerard E. Francisco, Anthony B. Ward, Joerg H. Wissel, Mauro Zampolini, Meghann M. Loven, Nathalie Berthuy, Abdallah Abouihia, Alessandra Calabrese, Leopold LS. Saltuari Tags: Category: Neurological Rehabilitation Source Type: research