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Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs
Thrombolytic therapy is the cornerstone of treatment of acute atherothrombotic ischemic stroke but is associated with brain hemorrhage; antiplatelet therapy has limited efficacy and is still associated with intracranial bleeding. Therefore, new antithrombotic approaches with a better efficacy/safety ratio are required. We have assessed the effect of ALX-0081, a Nanobody against the A1 domain of von Willebrand factor (VWF) that blocks VWF binding to GPIb, of the thrombolytic agent recombinant tissue plasminogen activator (rtPA), and of the GPIIb/IIIa antagonist tirofiban, in a middle cerebral artery (MCA) thrombosis model i...
Source: Blood - June 20, 2013 Category: Hematology Authors: Momi, S., Tantucci, M., Van Roy, M., Ulrichts, H., Ricci, G., Gresele, P. Tags: Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research

Predicting a post‐thrombolysis intracerebral hemorrhage: a systematic review
ConclusionsThe development and clinical application of ICH risk scores remains a developing field. Extensive external validation and impact studies are needed to strengthen evidence regarding their utility for improving the selection of ischemic stroke victims for thrombolysis while mitigating risks of complications through post‐thrombolysis ICH.
Source: Journal of Thrombosis and Haemostasis - May 15, 2013 Category: Hematology Authors: J. B. Echouffo‐Tcheugui, M. Woodward, A. P. Kengne Tags: Original Article Source Type: research

Predicting post‐thrombolysis intracerebral hemorrhage: A systematic review
Abstract ObjectivesFear of intracerebral hemorrhage (ICH) is a deterrent to the uptake of thrombolytic therapy, an evidence‐based treatment for acute ischemic stroke. Several characteristics associated with post‐thrombolysis ICH have been identified, but their combined utility for risk stratification has yet to be clarified. We critically examined risk models to predict post‐thrombolysis ICH, and evaluated their potential clinical utility. MethodsMEDLINE (Inception to October 2012) was searched and bibliographies of retrieved articles examined. Inclusion and exclusion criteria of each study were reviewed. Eligible st...
Source: Journal of Thrombosis and Haemostasis - March 7, 2013 Category: Hematology Authors: J B. Echouffo‐Tcheugui, M Woodward, A P Kengne Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

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