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Specialty: Hematology
Source: Platelets
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Total 95 results found since Jan 2013.
Immature platelets and cardiovascular events in patients with stable coronary artery disease
Platelets. 2023 Dec;34(1):2217960. doi: 10.1080/09537104.2023.2217960.ABSTRACTMany patients with coronary artery disease (CAD) have reduced the effect of aspirin, which may partly be explained by immature platelets. We aimed to investigate whether immature platelet markers can predict cardiovascular events in a large cohort of stable CAD patients. A total of 900 stable CAD patients were included and followed for a median of 3 years. We measured markers of immature platelets (platelet count, immature platelet count, immature platelet fraction, mean platelet volume, platelet distribution width, platelet mass, and thrombopoie...
Source: Platelets - May 29, 2023 Category: Hematology Authors: Oliver Buchhave Pedersen Sanne B øjet Larsen Steen Dalby Kristensen Anne-Mette Hvas Erik Lerkevang Grove Source Type: research
Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy
Platelets. 2022 Feb 2:1-10. doi: 10.1080/09537104.2021.2023735. Online ahead of print.ABSTRACTInterrogating platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill when causing heart attack, stroke, or pulmonary embolism. The underlying key receptor distributions and interactions, in particular the relevance of integrin clustering, are not fully understood is because of highly abundant and densely distributed αIIbβ3 receptors. This makes receptor distributions difficult to assess ev...
Source: Platelets - February 3, 2022 Category: Hematology Authors: Hannah S Heil Max Aigner Sophia Maier Prateek Gupta Luise M C Evers Vanessa G öb Charly Kusch Mara Meub Bernhard Nieswandt David Stegner Katrin G Heinze Source Type: research
Glycoprotein V : the unsolved GPV puzzle
Platelets. 2022 Jan 7:1-8. doi: 10.1080/09537104.2021.2022114. Online ahead of print.ABSTRACTGlycoprotein V (GPV) is a highly expressed 82 KDa platelet surface transmembrane protein which is loosely attached to the GPIb-IX complex. Despite remaining questions concerning its function, GPV presents several unique features which have repercussions in hematology, atherothrombosis, immunology and transfusion. GPV is specifically expressed in platelets and megakaryocytes and is an ideal marker and reporter gene for the late stages of megakaryopoiesis. The ectodomain of GPV can be released by a number of proteases, namely thrombi...
Source: Platelets - January 7, 2022 Category: Hematology Authors: Quentin Kimmerlin Sylvie Moog Catherine Ravanat Catherine Strassel Fran çois Lanza Source Type: research
Feasibility of platelet marker analysis in ischemic stroke patients and their association with one-year outcome. A pilot project within a subsample of the Stroke Induced Cardiac Failure in Mice and Men (SICFAIL) cohort study
Platelets. 2021 Dec 7:1-9. doi: 10.1080/09537104.2021.2002834. Online ahead of print.ABSTRACTPatients with ischemic stroke (IS) are at increased risk of mortality and recurrent cerebro- or cardiovascular events. Determining prognosis after IS remains challenging but blood-based biomarkers might provide additional prognostic information. As platelets are crucially involved in the pathophysiology of vascular diseases, platelet surface proteins (PSP) are promising candidates as prognostic markers in the hyperacute stage. In this pilot study, feasibility of PSP analysis by flow cytometry (HMGB1, CD84, CXCR4, CXCR7, CD62p with ...
Source: Platelets - December 8, 2021 Category: Hematology Authors: Mert Seyhan Kathrin Ungeth üm Michael K Schuhmann Daniel Mackenrodt Viktoria R ücker Felipe A Montellano Silke Wiedmann Dominik Rath Tobias Geisler Bernhard Nieswandt Peter Kraft Christoph Kleinschnitz Peter U Heuschmann Source Type: research
Significance of mild thrombocytopenia in maintenance hemodialysis patients; a retrospective cohort study
Platelets. 2021 Oct 21:1-8. doi: 10.1080/09537104.2021.1983531. Online ahead of print.ABSTRACTPlatelet activation in the hemodialysis (HD) circuit often causes thrombocytopenia. However, its clinical and pathophysiological significance has rarely been explored. Herein, we investigated the predictive value of thrombocytopenia for cardiovascular events (CVE) in maintenance HD patients and attempted to explore its mechanistic background considering recent knowledge of platelet dynamics. We conducted a retrospective cohort study on HD patients with the composite primary endpoint of predicting CVE, i.e., myocardial infarction, ...
Source: Platelets - October 21, 2021 Category: Hematology Authors: Yukiko Toyoda Kaoru Tateno Yorinobu Takeda Yoshio Kobayashi Source Type: research
Crushed/chewed administration of potent P2Y < sub > 12 < /sub > inhibitors in ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: Systematic review and meta-analysis
Platelets. 2021 Sep 2:1-8. doi: 10.1080/09537104.2021.1974370. Online ahead of print.ABSTRACTCrushed or chewed potent P2Y12 inhibitors are commonly used in the hope of bridging the gap of platelet inhibition in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). The study aimed to investigate the efficacy and safety of this alternative oral administration strategy by performing a meta-analysis of available randomized clinical trials (RCTs). PubMed, Embase, the Cochrane Library and Web of Science medical literature databases were searched for RCTs co...
Source: Platelets - September 2, 2021 Category: Hematology Authors: Chen Guo Jin-Rui Zhao Meng-Jie Chen Yue Zhang Rui-Yun Wu Qiang-Qiang Li Hong Zhao Jin Wei Source Type: research
