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Utility of intestinal intravital microscopy for the study of CNS injury-induced immunodepression syndrome (CIDS)
CONCLUSIONS: Our results suggest that PTS with subsequent LPS challenge poses as a viable model to further study CIDS using intravital microscopy of the intestinal microcirculation.PMID:34487026 | DOI:10.3233/CH-219109
Source: Clinical Hemorheology and Microcirculation - September 6, 2021 Category: Hematology Authors: Bashir Bietar Juan Zhou Christian Lehmann Source Type: research

Increased whole blood viscosity is associated with silent cerebral infarction.
CONCLUSIONS: Whole blood viscosity at low shear rate is a novel indicator for SCI regardless of classical cardiovascular risk factors. Early measurement of whole blood viscosity may be helpful to assess the risk of stroke. PMID: 23988733 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - August 29, 2013 Category: Hematology Authors: Li RY, Cao ZG, Li Y, Wang RT Tags: Clin Hemorheol Microcirc Source Type: research

CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs)
CONCLUSION: CircSEC11A promoted the malignant progression in OGD-induced HBMECs through the mediation of miR-29a-3p/SEMA3A axis. This study has provided the new insight into the underlying application of circSEC11A in cell model of ischemic stroke.PMID:36872771 | DOI:10.3233/CH-221689
Source: Clinical Hemorheology and Microcirculation - March 6, 2023 Category: Hematology Authors: Ziying Zhou Qian Hu Hongmei Guo Xijia Wang Source Type: research

Hemorheological alterations in sickle cell anemia and their clinical consequences - the role of genetic modulators.
Abstract Sickle cell anemia (SCA) is an autosomal recessive disease caused by the HBB:c.20A>T mutation that leads to hemoglobin S synthesis. The disease presents with high clinical heterogeneity characterized by chronic hemolysis, recurrent episodes of vaso-oclusion and infection. This work aimed to characterize by in silico studies some genetic modulators of severe hemolysis and stroke risk in children with SCA, and understand their consequences at the hemorheological level.Association studies were performed between hemolysis biomarkers as well as the degree of cerebral vasculopathy and the inheritance of seve...
Source: Clinical Hemorheology and Microcirculation - November 3, 2016 Category: Hematology Authors: Silva M, Vargas S, Coelho A, Dias A, Ferreira T, Morais A, Maia R, Kjöllerström P, Lavinha J, Faustino P Tags: Clin Hemorheol Microcirc Source Type: research

Evidence-based hemorheology. Does  it exist? Applying evidence from clinical studies to the individual patient.
Evidence-based hemorheology. Does it exist? Applying evidence from clinical studies to the individual patient. Clin Hemorheol Microcirc. 2016 Nov 4; Authors: Vaz Carneiro A Abstract Clinicians are used to treat individual patients, and therefore may feel that clinical trials and systematic reviews do not give information for optimal treatment of the single patient.Evidence Based Medicine (EBM) is the integration of research evidence (from clinically relevant studies conducted using sound methodology) with clinical expertise (clinician's cumulated experience) and patient values (personal preference...
Source: Clinical Hemorheology and Microcirculation - November 3, 2016 Category: Hematology Authors: Vaz Carneiro A Tags: Clin Hemorheol Microcirc Source Type: research

Non-invasive evaluation of macro- and microhemodynamic changes during induction of general anesthesia - A prospective observational single-blinded trial.
CONCLUSION: Non-invasive determination of CO provides additional hemodynamic information during anesthesia, showing that induction results in a significant decrease not only of MAP but also of CO and other cardiac factors at all timepoints compared to baseline values. The decrease of CO was greater than that of MAP and, in contrast to MAP, did not respond to NE. There was also no sign of a positive inotropic effect of NE in this situation. Support of MAP by NE must consequently result from an increase in peripheral arterial resistance, posing a risk for oxygen supply to tissue. In addition, general anesthesia and the opera...
Source: Clinical Hemorheology and Microcirculation - January 5, 2020 Category: Hematology Authors: Brettner F, Heitzer M, Thiele F, Hulde N, Nussbaum C, Achatz S, Jacob M, Becker BF, Conzen P, Kilger E, Chappell D Tags: Clin Hemorheol Microcirc Source Type: research

Cerebrovascular comorbidity, high blood levels of C - reactive protein and D-dimer are associated with disease outcomes in COVID-19 patients.
Abstract The emerging coronavirus disease (COVID-19) swept the world, affecting more than 200 countries and territories. As of August 22, 2020, the pandemic infected more than 23,329,752 including 807,054 patients who have died. Although the main clinical features of the pandemic disease are respiratory, cerebrovascular comorbidities emerged as one of the leading causes of death associated with COVID-19. Different case reports have indicated that C-reactive protein (CRP) and D-dimer (pro-inflammatory biomarkers) were elevated in COVID-19 patients, which can significantly increase the risk of ischemic stroke. Avail...
Source: Clinical Hemorheology and Microcirculation - November 11, 2020 Category: Hematology Authors: Alzoughool F, Alanagreh L, Abumweis S, Atoum M Tags: Clin Hemorheol Microcirc Source Type: research

Polymorphonuclear phenotypical expression of CD18, at baseline and after in vitro activation, in several clinical disorders: Revision of our case series
CONCLUSIONS: in the different clinical disorders, the trend of this integrin subunit provides some specific information, useful to select the best therapeutic strategy in clinical practice.PMID:37482987 | DOI:10.3233/CH-231771
Source: Clinical Hemorheology and Microcirculation - July 24, 2023 Category: Hematology Authors: Gregorio Caimi Rosalia Lo Presti Caterina Carollo Maria Montana Melania Carlisi Source Type: research

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