Non-invasive evaluation of macro- and microhemodynamic changes during induction of general anesthesia - A prospective observational single-blinded trial.

CONCLUSION: Non-invasive determination of CO provides additional hemodynamic information during anesthesia, showing that induction results in a significant decrease not only of MAP but also of CO and other cardiac factors at all timepoints compared to baseline values. The decrease of CO was greater than that of MAP and, in contrast to MAP, did not respond to NE. There was also no sign of a positive inotropic effect of NE in this situation. Support of MAP by NE must consequently result from an increase in peripheral arterial resistance, posing a risk for oxygen supply to tissue. In addition, general anesthesia and the operative stimulus lead to an impairment of the microcirculation.
PMID: 31929147 [PubMed - as supplied by publisher]

Source: Clinical Hemorheology and Microcirculation - January 5, 2020 Category: Hematology Authors: Brettner F, Heitzer M, Thiele F, Hulde N, Nussbaum C, Achatz S, Jacob M, Becker BF, Conzen P, Kilger E, Chappell D Tags: Clin Hemorheol Microcirc Source Type: research