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Polymorphonuclear phenotypical expression of CD18, at baseline and after in vitro activation, in several clinical disorders: Revision of our case series
CONCLUSIONS: in the different clinical disorders, the trend of this integrin subunit provides some specific information, useful to select the best therapeutic strategy in clinical practice.PMID:37482987 | DOI:10.3233/CH-231771
Source: Clinical Hemorheology and Microcirculation - July 24, 2023 Category: Hematology Authors: Gregorio Caimi Rosalia Lo Presti Caterina Carollo Maria Montana Melania Carlisi Source Type: research

Changes of the cutaneous flowmotion pattern after limb revascularization in patient with critical ischemia.
In conclusion after limb revascularization the cardiac component of the flowmotion increased maybe because the cardiac stroke volume had more influence over the skin arterioles. PMID: 23823124 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - July 3, 2013 Category: Hematology Authors: Martini R, Ticcinelli V, Bagno A Tags: Clin Hemorheol Microcirc Source Type: research

Prospective clinical trial on dosage optimizing of tranexamic acid in non-emergency cardiac surgery procedures.
CONCLUSION: Use of 1 g TxA is safe and sufficient for elective patients with on pump cardiac surgery and thus has been established as strategy of choice in our center. PMID: 24113504 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - October 10, 2013 Category: Hematology Authors: Waldow T, Szlapka M, Haferkorn M, Bürger L, Plötze K, Matschke K Tags: Clin Hemorheol Microcirc Source Type: research

Cocaine in high concentrations inhibits platelet aggregation in vitro.
Abstract Complications of cocaine administration are acute vascular occlusions such as myocardial infarction and stroke. We have studied the influence of cocaine on platelet function in vitro. For that purpose, citrated blood from healthy volunteers was incubated with cocaine concentrations of 0 (control), 10, 100, 1000, 2500, and 10'000 μmol/l plasma. Platelet aggregation was measured in whole blood under high shear flow conditions with a platelet function analyzer PFA-100 using either epinephrine (EPI) or ADP as a platelet activator, as well as in non-flowing blood measuring the change of impedance after the ad...
Source: Clinical Hemorheology and Microcirculation - October 31, 2013 Category: Hematology Authors: Cagienard F, Schulzki T, Reinhart WH Tags: Clin Hemorheol Microcirc Source Type: research

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome.
Abstract Obstructive sleep apnea syndrome (OSAS) is associated with an elevated risk of cardiovascular events and stroke. Matrix metalloproteinases (MMPs) are endopeptidases involved in extracellular matrix degradation and then in the development and progression of cardiovascular diseases. Our aim was to evaluate plasma levels of gelatinases (MMP-2 and MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2) in a group of subjects with OSAS. We enrolled 48 subjects (36 men and 12 women; mean age 49.7 ± 14.68 yrs) with OSAS diagnosed with a 1-night cardiorespiratory study and then we subdivided these subjects into t...
Source: Clinical Hemorheology and Microcirculation - March 10, 2015 Category: Hematology Authors: Hopps E, Canino B, Montana M, Calandrino V, Urso C, Lo Presti R, Caimi G Tags: Clin Hemorheol Microcirc Source Type: research

Association of whole blood viscosity with non-alcoholic fatty liver disease.
CONCLUSIONS: The findings showed that WBV at low shear stress is increased in NAFLD. Moreover, WBV at low shear stress is independently associated with NAFLD even after adjusting other cardiovascular risk factors. PMID: 26444605 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - September 25, 2015 Category: Hematology Authors: Yu XY, Li Y, Liu T, Wang RT Tags: Clin Hemorheol Microcirc Source Type: research

Hemorheological alterations in carotid artery stenosis.
CONCLUSION: Although hemorheological parameters are impaired both in CAS and chronic cerebrovascular disorders, the severity of stenosis cannot be detected based on hemorheological parameters. Our investigation suggests that alteration of hemorheological parameters could indicate carotid atherosclerosis. PMID: 26890237 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - February 17, 2016 Category: Hematology Authors: Totsimon K, Nagy A, Sandor B, Biro K, Csatho A, Szapary L, Toth K, Marton Z, Kenyeres P Tags: Clin Hemorheol Microcirc Source Type: research

Inflammation in sickle cell disease.
Abstract The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant pathophysiological consequences that result in hemolytic events and the induction of the inflammatory processes that ultimately lead to vaso-occlusion. In addition to their role in the initiation of the acute painful vaso-occlusive episodes that are characteristic of SCD, inflammatory processes are also key components of many of the complications of the disease including autosplenectomy, acute chest syndrome, pulmonary hypertension, leg ulcers, nephropathy and stroke. We, herein, discuss the events that trigger infla...
Source: Clinical Hemorheology and Microcirculation - April 5, 2018 Category: Hematology Authors: Conran N, Belcher JD Tags: Clin Hemorheol Microcirc Source Type: research

Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: What should be our goals for transfusion therapy?
Abstract Sickle cell anemia is characterized by a mutation resulting in the formation of an abnormal beta-hemoglobin called hemoglobin S. Hemoglobin S polymerizes upon deoxygenation, causing impaired red blood cell deformability and increased blood viscosity at equivalent hematocrits. Thus, sickle cell disease is a hemorheologic disease that results in various pathologic processes involving multiple organ systems including the lungs, heart, kidneys and brain. Red blood cell mechanics and the perturbations on blood flow-endothelial interaction underlie much of the pathology found in sickle cell disease. Transfusion...
Source: Clinical Hemorheology and Microcirculation - April 5, 2018 Category: Hematology Authors: Detterich JA Tags: Clin Hemorheol Microcirc Source Type: research

Genetic modifiers of severity in sickle cell disease.
Abstract Sickle cell disease (SCD) is one of the most common single disease disorders world-wide. It is remarkable for its clinical heterogeneity, even among individuals with identical genotypes. Some individuals experience morbidity and mortality in early childhood, while others have a relatively mild course, and normal or near normal life expectancy. Many clinical complications are associated with SCD; most notably frequent pain episodes, stroke, acute chest syndrome, avascular necrosis, nephropathy, retinopathy and pulmonary hypertension. While the effects of higher fetal hemoglobin (HbF) levels, UGTA1A polymor...
Source: Clinical Hemorheology and Microcirculation - April 5, 2018 Category: Hematology Authors: Chang AK, Ginter Summarell CC, Birdie PT, Sheehan VA Tags: Clin Hemorheol Microcirc Source Type: research

Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells.
Abstract Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic pro...
Source: Clinical Hemorheology and Microcirculation - September 6, 2020 Category: Hematology Authors: Krüger-Genge A, Jung F, Hufert F, Jung EM, Küpper JH, Storsberg J Tags: Clin Hemorheol Microcirc Source Type: research

Carotid artery vulnerable plaque model for cerebrovascular events by conventional ultrasound & amp; contrast-enhanced ultrasound: A preliminary study
CONCLUSION: The vulnerable plaque model established by conventional ultrasound combined with contrast-enhanced ultrasound has good diagnostic value for the characteristic plaque of carotid artery with cerebrovascular events.PMID:34511491 | DOI:10.3233/CH-211216
Source: Clinical Hemorheology and Microcirculation - September 13, 2021 Category: Hematology Authors: Qin Wang Yunqian Huang Yuke Zhang Yuqun Wang Yanchun Xie Lixia Zhang Ying Lu Man Chen Source Type: research

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