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Prothrombin Complex Concentrate (PCC) for Non‐Vitamin K Oral Anticoagulant (NOAC) reversal: Good enough for now?
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2014 Category: Hematology Authors: Mike Makris Tags: Commentary Source Type: research

Case Report: Monitoring the Anticoagulant Effect After a Massive Rivaroxaban Overdose
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - July 1, 2014 Category: Hematology Authors: Lori‐Ann Linkins, Karen Moffat Tags: Case Report Source Type: research

Contraceptive pills and thrombosis : effects of the French crisis on prescriptions and consequences for medicine agencies
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - July 1, 2014 Category: Hematology Authors: Joseph Emmerich, Camille Thomassin, Mahmoud Zureik Tags: Forum Source Type: research

Monitoring the anticoagulant effect after a massive rivaroxaban overdose
We report the case of a 42‐year‐old man who took an overdose of 1400 mg of rivaroxaban and describe how resolution of the anticoagulant effect was monitored using readily available coagulation assays.
Source: Journal of Thrombosis and Haemostasis - August 11, 2014 Category: Hematology Authors: L.‐A. Linkins, K. Moffat Tags: Case of the Month Source Type: research

Dabigatran adherence in atrial fibrillation patients during the first year after diagnosis: a nationwide cohort study
ConclusionMore than 75% of patients were adherent >80% during the first year. Patients with higher morbidity, including patients with a higher risk of stroke or bleeding, exhibited better adherence. This improvement may be attributable to more regular contact with the health care system.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 1, 2015 Category: Hematology Authors: Anders Gorst‐Rasmussen, Flemming Skjøth, Torben Bjerregaard Larsen, Lars Hvilsted Rasmussen, Gregory Y.H. Lip, Deirdre A. Lane Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Antithrombotic Therapy for Left Ventricular Assist Devices in Adults: a Systematic Review
ConclusionsOf 977 manuscripts, 24 articles met the inclusion criteria of adults with implanted LVADs where clinical outcomes were defined based on anticoagulant and/or antiplatelet regimen. Most studies reported treatment with unfractionated heparin post‐operatively which was transitioned to a vitamin K antagonist (VKA). Goal INR varied between 1.5‐3.5. Antiplatelet regimens ranged from no treatment to dual therapy. Definition of major bleeding differed between trials and incidence varied between 0% and 58%. The available evidence could not demonstrate a clear benefit of aspirin compared with VKA therapy alone [stroke...
Source: Journal of Thrombosis and Haemostasis - April 6, 2015 Category: Hematology Authors: Lisa Baumann Kreuziger, Benjamin Kim, Georg M. Wieselthaler Tags: Review Article Source Type: research

Factor XI and Contact Activation as Targets for Antithrombotic Therapy
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Source: Journal of Thrombosis and Haemostasis - May 1, 2015 Category: Hematology Authors: David Gailani, Charles E. Bane, Andras Gruber Tags: Review Article Source Type: research

A Phase II, Double‐Blind, Randomized, Parallel Group, Dose Finding Study of the Safety and Tolerability of Darexaban Compared with Warfarin in Patients with Non‐Valvular Atrial Fibrillation
ConclusionsIn this Phase II study in patients with NVAF, a lower bleeding rate was observed in the 120mg daily dose group of darexaban compared to warfarin and plasma D‐dimer as marker for haemostasis was reduced. Further investigation of the optimal dose of darexaban for the prevention of stroke in patients with NVAF would need to be considered.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2015 Category: Hematology Authors: Gregory YH Lip, Jonathan L Halperin, Palle Petersen, George M Rodgers, Denes Pall, Ronny W Renfurm Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Plasma ADAMTS13 levels and the risk of myocardial infarction: an individual patient data meta‐analysis
ConclusionLow levels of ADAMTS13 are associated with an increased risk of MI.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2015 Category: Hematology Authors: A. Maino, B. Siegerink, L. A. Lotta, J. T. B. Crawley, S. le Cessie, F. W. G. Leebeek, D. A. Lane, G. D. O. Lowe, F. Peyvandi, F. R. Rosendaal Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Global Public Awareness of Venous Thromboembolism
ConclusionsOn a global level, public awareness about thrombosis overall, and of VTE in particular, is low. Campaigns to increase public awareness about VTE are needed to reduce the burden from this largely preventable thrombotic disorder.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2015 Category: Hematology Authors: Aaron M Wendelboe, Micah McCumber, Elaine M Hylek, Harry Buller, Jeffrey I Weitz, Gary Raskob, Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Plasma ADAMTS‐13 levels and the risk of myocardial infarction: an individual patient data meta‐analysis
ConclusionsLow ADAMTS‐13 levels are associated with an increased risk of myocardial infarction.
Source: Journal of Thrombosis and Haemostasis - July 14, 2015 Category: Hematology Authors: A. Maino, B. Siegerink, L. A. Lotta, J. T. B. Crawley, S. Cessie, F. W. G. Leebeek, D. A. Lane, G. D. O. Lowe, F. Peyvandi, F. R. Rosendaal Tags: Original Article Source Type: research

New Paradigms in Sepsis: From Prevention to Protection of Failing Microcirculation
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Source: Journal of Thrombosis and Haemostasis - July 1, 2015 Category: Hematology Authors: J. Hawiger, R. A Veach, J. Zienkiewicz Tags: Review Article Source Type: research

Hemodialysis for the treatment of dabigatran‐associated bleeding: a case report and systematic review
ConclusionsIn patients with dabigatran associated bleeding, RRT appears to be effective in reducing dabigatran concentrations and in case reports this has been associated with a reduction in duration and/or severity of bleeding. However, a rebound in concentrations may be seen following withdrawal of RRT suggesting that a prolonged course of RRT may be more effective.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - August 1, 2015 Category: Hematology Authors: Chatree Chai‐Adisaksopha, Christopher Hillis, Wendy Lim, Kochawan Boonyawat, Karen Moffat, Mark Crowther Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Stroke in atrial fibrillation and improving the identification of ‘high‐risk’ patients: the crossroads of immunity and thrombosis
Source: Journal of Thrombosis and Haemostasis - September 21, 2015 Category: Hematology Authors: E. Shantsila, G. Y. H. Lip Tags: Commentary Source Type: research

Global public awareness of venous thromboembolism: comment
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Source: Journal of Thrombosis and Haemostasis - November 1, 2015 Category: Hematology Authors: A. Aggarwal, F. R. Rickles Tags: Letter ‐ to the Editor Source Type: research

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