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Up-regulation of VCAM1 Relates to Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.
Abstract Vascular cell adhesion molecule 1 (VCAM1) is a member of the Immunoglobulin superfamily and encodes a cell surface sialoglycoprotein expressed in cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion, facilitates the downstream signaling, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Accumulating evidence has demonstrated that VCAM1 exerts an anti-apoptotic effect in several tumor tissues such as ovarian cancer and breast cancer. Intracerebral hemorrhage (ICH) is the second most common subtype of stroke with high mo...
Source: Neurochemical Research - April 14, 2015 Category: Neuroscience Authors: Zhang D, Yuan D, Shen J, Yan Y, Gong C, Gu J, Xue H, Qian Y, Zhang W, He X, Yao L, Ji Y, Shen A Tags: Neurochem Res Source Type: research

Multiple faces of protein interacting with C kinase 1 (PICK1): structure, function, and diseases
Publication date: Available online 9 March 2016 Source:Neurochemistry International Author(s): Yun-Hong Li, Nan Zhang, Ya-Nan Wang, Ying Shen, Yin Wang Protein interacting with C-kinase 1 (PICK1) has received considerable attention because it is the only protein that contains both PSD-95/DlgA/ZO-1 (PDZ) domain and Bin-Amphiphysin-Rvs (BAR) domain. Through PDZ and BAR domains, PICK1 binds to a large number of membrane proteins and lipid molecules, and is thereby of multiple functions. PICK1 is widely expressed in various tissues, particularly abundant in the brain and testis. In the central nervous system (CNS), PICK...
Source: Neurochemistry International - March 9, 2016 Category: Neuroscience Source Type: research

The independent risks and specific biomarker of breast cancer-related ischemic stroke
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Source: International Journal of Neuroscience - March 1, 2020 Category: Neuroscience Authors: Xuemin Cheng Qixiong Qin Lizhi Lu Chunyong Chen Yunfei Wei Dacheng Wang Haihua Li Guohui Li Hongbin Liang Shengyu Li Daobin Cheng Zhijian Liang Source Type: research