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Post‐stroke epilepsy in Polish paediatric patients
AimThe aim of this study was to characterize a group of children with early and late remote seizures which occurred after arterial ischaemic stroke (AIS) and to find predictors of post‐stroke seizures. MethodThe study group, recruited in the Department of Neuropediatrics (Medical University of Silesia, Katowice, Poland), comprised 78 patients who had had a stroke: 13 patients had early seizures occurring up to 7 days after the stroke, seven patients had late remote seizures occurring more than 7 days after the stroke, and 58 patients had no seizure. Univariate log‐rank tests and Cox proportional hazard models were us...
Source: Developmental Medicine and Child Neurology - October 5, 2013 Category: Child Development Authors: Ilona Kopyta, Beata Sarecka‐Hujar Tags: Original Article Source Type: research

Quality of life after paediatric ischaemic stroke
We examined long‐term QoL after arterial ischaemic stroke concerning different variables. MethodChildren registered in the Swiss Neuropediatric Stroke Registry and suffering from arterial ischaemic stroke between 2000 and 2008 were included. Two years post‐stroke, assessments included intelligence quotient tests for cognitive impairment and modified Rankin Scale (mRS) for neurological impairment; 5 years post‐stroke, the Kidscreen‐27 was used for QoL, DSM‐IV criteria screening was used for attention deficits, and the ABILHAND‐Kids was used for manual motor skills. Age at stroke, sex, socioeconomic status, lesio...
Source: Developmental Medicine and Child Neurology - October 21, 2016 Category: Child Development Authors: Salome Kornfeld, Martina Studer, Stephanie Winkelbeiner, M ária Regényi, Eugen Boltshauser, Maja Steinlin, Tags: Original Article Source Type: research

Neurodevelopmental outcome after neonatal perforator stroke
AimTo assess outcome after neonatal perforator stroke in the largest cohort to date. MethodSurvivors from a cohort of children diagnosed with neonatal perforator stroke using cranial ultrasound or magnetic resonance imaging were eligible for inclusion. Recovery and Recurrence Questionnaire score, presence of cerebral palsy (CP), and crude outcome were assessed, specifically (1) the ability to walk independently, (2) participation in regular education, and (3) the presence of epilepsy. ResultsThirty‐seven patients (20 males, 17 females) aged 3 to 14 years (mean age 8y) were included in the study: 14 with isolated single ...
Source: Developmental Medicine and Child Neurology - July 27, 2015 Category: Child Development Authors: Ginette M Ecury‐Goossen, Marit Haer, Liesbeth S Smit, Monique Feijen‐Roon, Maarten Lequin, Rogier C J Jonge, Paul Govaert, Jeroen Dudink Tags: Original Article Source Type: research

A pediatric institutional acute stroke protocol improves timely access to stroke treatment
AimWe aimed to evaluate whether an institutional acute stroke protocol (ASP) could accelerate the diagnosis and secondary treatment of pediatric stroke. MethodWe initiated an ASP in 2005. We compared 209 children (125 males, 84 females; median age 4.8y, interquartile range [IQR] 1.2–9.3y, range 0.09–17.7y) diagnosed with arterial ischemic stroke ‘pre‐protocol’ (1992–2004) to 112 children (60 males, 52 females; median age 5.8y, IQR 1.0–11.4y, range 0.08–17.7y) diagnosed ‘post‐protocol’ (2005–2012) for time‐to‐diagnosis, mode of diagnostic imaging, and time‐to‐treatment with antithrombotic med...
Source: Developmental Medicine and Child Neurology - July 31, 2016 Category: Child Development Authors: Melissa Shack, Andrea Andrade, Priyanka P Shah ‐Basak, Manohar Shroff, Mahendranath Moharir, Ivanna Yau, Rand Askalan, Daune MacGregor, Mubeen F Rafay, Gabrielle A deVeber Tags: Original Article Source Type: research

Development and validation of the Pediatric Stroke Quality of Life Measure
AimTo develop and validate a disease‐specific parent proxy and child quality of life (QoL) measure for patients aged 2 to 18 years surviving cerebral sinovenous thrombosis (CSVT) and arterial ischaemic stroke (AIS). MethodUtilizing qualitative and quantitative methods, we developed a 75‐item Pediatric Stroke Quality of Life Measure (PSQLM) questionnaire. We mailed the PSQLM and a standardized generic QoL measure, Pediatric Quality of Life Inventory (PedsQL), to 353 families. Stroke type, age at stroke, and neurological outcome on the Pediatric Stroke Outcome Measure were documented. We calculated the internal consiste...
Source: Developmental Medicine and Child Neurology - February 16, 2018 Category: Child Development Authors: Andrea Fiume, Gabrielle Deveber, Shu ‐Hyun Jang, Colleen Fuller, Shani Viner, Sharon Friefeld Tags: Original Article Source Type: research

Association between radiographic Wallerian degeneration and neuropathological changes post childhood stroke
Aim  Wallerian degeneration is a radiological finding thought to reflect corticospinal tract degeneration. This finding on magnetic resonance imaging (MRI) is routinely used as a predictor of poor prognosis in childhood stroke. However, its validity has never been established. Our objective was to correlate Wallerian degeneration seen on MRI with histopathology. Method  We searched the databases of the Department of Pathology and Children’s Stroke registry at the Hospital for Sick Children, Toronto for autopsy specimens exhibiting focal infarcts from children born at term who underwent MRI after a stroke. The specime...
Source: Developmental Medicine and Child Neurology - November 22, 2012 Category: Child Development Authors: KEVIN C JONES, CYNTHIA HAWKINS, DEREK ARMSTRONG, GABRIELLE DEVEBER, DAUNE MACGREGOR, MAHENDRANATH MOHARIR, RAND ASKALAN Tags: ORIGINAL ARTICLE Source Type: research

Risk of stroke among patients with cerebral palsy: a population‐based cohort study
AimThe aim of the study was to investigate the risk of stroke in patients with cerebral palsy (CP), based on nationwide data in Taiwan. MethodThis prospective cohort study was comprised of patients recorded on the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005) who had a diagnosis of CP (n=1975) in records between 1 January 2004 and 31 December 2007. A comparison group (1:5) drawn from the same database was matched for age and sex (n=9875). Each patient was tracked by data until the development of stroke or the end of 2008. Cox proportional‐hazards regression analysis was used to evaluate the hazard ratios ...
Source: Developmental Medicine and Child Neurology - June 27, 2016 Category: Child Development Authors: Chin‐Wen Wu, Shih‐Wei Huang, Jia‐Wei Lin, Tsan‐Hon Liou, Lin‐Chuan Chou, Hui‐Wen Lin Tags: Original Article Source Type: research

Risk of stroke among patients with cerebral palsy: a population ‐based cohort study
AimThe aim of the study was to investigate the risk of stroke in patients with cerebral palsy (CP), based on nationwide data in Taiwan. MethodThis prospective cohort study was comprised of patients recorded on the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005) who had a diagnosis of CP (n=1975) in records between 1 January 2004 and 31 December 2007. A comparison group (1:5) drawn from the same database was matched for age and sex (n=9875). Each patient was tracked by data until the development of stroke or the end of 2008. Cox proportional‐hazards regression analysis was used to evaluate the hazard ratios ...
Source: Developmental Medicine and Child Neurology - June 26, 2016 Category: Child Development Authors: Chin ‐Wen Wu, Shih‐Wei Huang, Jia‐Wei Lin, Tsan‐Hon Liou, Lin‐Chuan Chou, Hui‐Wen Lin Tags: Original Article Source Type: research

Prolonged or recurrent acute seizures after pediatric arterial ischemic stroke are associated with increasing epilepsy risk
AimTo determine epilepsy risk factors after pediatric stroke. MethodA cohort of children with arterial ischemic stroke (birth–18y) was enrolled at 21 centers and followed for 1 year. Acute seizures (≤7d after stroke) and active epilepsy (at least one unprovoked remote seizure plus maintenance anticonvulsant at 1y) were identified. Predictors were determined using logistic regression. ResultsAmong 114 patients (28 neonates and 86 children) enrolled, 26 neonates (93%) and 32 children (37%) had an acute seizure. Acute seizures lasted longer than 5 minutes in 23 patients (40%) and were frequently recurrent: 33 (57%) had 2 ...
Source: Developmental Medicine and Child Neurology - July 15, 2016 Category: Child Development Authors: Christine K Fox, Mark T Mackay, Michael M Dowling, Paola Pergami, Luigi Titomanlio, Gabrielle Deveber, Tags: Original Article Source Type: research

Psychosocial function in the first year after childhood stroke
This study aims to describe psychosocial function within the first year after childhood stroke, and to identify factors associated with outcome. MethodThirty‐seven children were involved in a prospective, longitudinal study investigating recovery over the first year after childhood stroke. Children's social functioning was assessed at 6‐months and 12‐months poststroke and psychological function at 12‐months poststroke, using standardized measures. ResultsMean social function was poorer at both 6‐months and 12‐months poststroke, compared to prestroke. Psychological problems were more common than expected, with e...
Source: Developmental Medicine and Child Neurology - January 24, 2017 Category: Child Development Authors: Mardee Greenham, Vicki Anderson, Stephen Hearps, Michael Ditchfield, Lee Coleman, Mark T Mackay, Paul Monagle, Anne L Gordon Tags: Original Article Source Type: research

Early predictors of psychosocial functioning 5 years after paediatric stroke
This study aimed to evaluate psychosocial outcomes in children 5 years after paediatric stroke and explore the contribution of early presenting factors. MethodThirty‐one children (19 males and 12 females) with arterial ischemic stroke were involved in this prospective, longitudinal study. Children underwent intellectual assessment at 12 months poststroke and parents completed questionnaires rating their own mental health and their child's functioning at 12 months and 5 years poststroke. ResultsAt 5‐year follow‐up, psychological and social function were significantly poorer than normative expectations. Exploration of ...
Source: Developmental Medicine and Child Neurology - August 17, 2017 Category: Child Development Authors: Mardee Greenham, Vicki Anderson, Anna Cooper, Stephen Hearps, Michael Ditchfield, Lee Coleman, Rod W Hunt, Mark T Mackay, Paul Monagle, Anne L Gordon Tags: Original Article Source Type: research

Neonatal posterior cerebral artery stroke: clinical presentation, MRI findings, and outcome
AimTo report the clinical presentation, magnetic resonance imaging (MRI) findings, and follow‐up data of newborn infants with perinatal arterial ischemic stroke in the territory of the posterior cerebral artery (PCA). MethodData on 18 newborn infants from three neonatal intensive care units (11 males, seven females) with an MRI‐confirmed PCA stroke were analysed and reported. Infants were born at a mean gestational age of 38.7 weeks (SD 3.4) with a mean birthweight of 3244g (SD 850). ResultsFourteen infants presented with clinical seizures. Five of these had associated hypoxic–ischemic encephalopathy, four had hypog...
Source: Developmental Medicine and Child Neurology - January 22, 2013 Category: Child Development Authors: Niek E Aa, Jeroen Dudink, Manon J N L Benders, Paul Govaert, Henrica L M Straaten, Giorgio L Porro, Floris Groenendaal, Linda S Vries Tags: Original Article Source Type: research

Feeding and swallowing impairment in children with stroke and unilateral cerebral palsy: a systematic review
AimThis systematic review targeted frequency estimates of dysphagia (feeding and swallowing problems), related health outcomes, and caregiver burden in children with stroke or unilateral cerebral palsy (CP).MethodSix electronic databases were searched from their inception to November 2017 along with a manual search of eight relevant journals. Two blinded raters assessed abstracts and full articles for eligibility. Discrepancies were resolved by consensus. Accepted articles were evaluated for quality. Data were extracted and analysed descriptively.ResultsOf 1660 abstracts, five met inclusion criteria, of which three focused...
Source: Developmental Medicine and Child Neurology - November 9, 2018 Category: Child Development Authors: Victoria Sherman, Elissa Greco, Mahendranath Moharir, Deryk Beal, Kevin Thorpe, Rosemary Martino Tags: Systematic Review Source Type: research

Planning interventional trials in childhood arterial ischaemic stroke using a Delphi consensus process
ConclusionThe Delphi consensus process is an efficient method of identifying and planning paediatric stroke trials. An international, multicentre trial is now in preparation.
Source: Developmental Medicine and Child Neurology - January 25, 2017 Category: Child Development Authors: Maja Steinlin, Finbar O'callaghan, Mark T Mackay Tags: Original Article Source Type: research

Global suppression of electrocortical activity in unilateral perinatal thalamic stroke
We present an unusual case of persistent generalized electroencephalography (EEG) suppression and right‐sided clonic seizures in a male infant born at 40+2 weeks' gestation, birthweight 3240g, with an isolated unilateral thalamic stroke. The EEG at 13 hours after birth showed a generalized very low amplitude background pattern, which progressed to frequent electrographic seizures over the left hemisphere. The interictal background EEG pattern remained grossly abnormal over the next 48 hours, showing very low background amplitudes (<10μV). Magnetic resonance imaging revealed an isolated acute left‐sided thalamic i...
Source: Developmental Medicine and Child Neurology - January 14, 2014 Category: Child Development Authors: Liudmila Kharoshankaya, Peter M Filan, Conor O Bogue, Deirdre M Murray, Geraldine B Boylan Tags: Case Report Source Type: research

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