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A pediatric institutional acute stroke protocol improves timely access to stroke treatment
AimWe aimed to evaluate whether an institutional acute stroke protocol (ASP) could accelerate the diagnosis and secondary treatment of pediatric stroke. MethodWe initiated an ASP in 2005. We compared 209 children (125 males, 84 females; median age 4.8y, interquartile range [IQR] 1.2–9.3y, range 0.09–17.7y) diagnosed with arterial ischemic stroke ‘pre‐protocol’ (1992–2004) to 112 children (60 males, 52 females; median age 5.8y, IQR 1.0–11.4y, range 0.08–17.7y) diagnosed ‘post‐protocol’ (2005–2012) for time‐to‐diagnosis, mode of diagnostic imaging, and time‐to‐treatment with antithrombotic med...
Source: Developmental Medicine and Child Neurology - July 31, 2016 Category: Child Development Authors: Melissa Shack, Andrea Andrade, Priyanka P Shah ‐Basak, Manohar Shroff, Mahendranath Moharir, Ivanna Yau, Rand Askalan, Daune MacGregor, Mubeen F Rafay, Gabrielle A deVeber Tags: Original Article Source Type: research

Planning interventional trials in childhood arterial ischaemic stroke using a Delphi consensus process
ConclusionThe Delphi consensus process is an efficient method of identifying and planning paediatric stroke trials. An international, multicentre trial is now in preparation.
Source: Developmental Medicine and Child Neurology - January 25, 2017 Category: Child Development Authors: Maja Steinlin, Finbar O'callaghan, Mark T Mackay Tags: Original Article Source Type: research

Basilar artery strokes in children: good outcomes with conservative medical treatment
AimTo describe outcomes and outcome predictors in childhood basilar artery stroke (BAS). MethodWe prospectively enrolled children with BAS with or without basilar artery occlusion (BAO) in the Toronto Children's Stroke Registry from 1992 to 2009. We assessed presenting features and outcomes including Pediatric Stroke Outcome Measure scores. ResultsAmong 578 children with acute arterial ischemic stroke, 27 had BAS (4.6% including neonates, 6% excluding neonates). Twenty‐four (14 males, 10 females) children met study criteria (mean age at stroke was 8y 10mo; range 0–17y). Eleven children had BAO. Aspirin or anticoagulati...
Source: Developmental Medicine and Child Neurology - February 17, 2013 Category: Child Development Authors: Ana Marissa Lagman‐Bartolome, Ann‐Marie Pontigon, Mahendranath Moharir, Daune L. Macgregor, Rand Askalan, Ivanna Yau, Gabrielle Deveber Tags: Original Article Source Type: research

Cerebrovascular disease in children with HIV‐1 infection
An estimated 3.2 million children worldwide have human immunodeficiency virus (HIV) infection. Antiretroviral therapy (ART) has resulted in prolonged survival, leading to an increase in complications previously recognized in adults. Children with HIV infection have increased risk of cerebrovascular disease from multiple aetiologies including HIV‐associated vasculopathy, opportunistic vasculitis, cardioembolism or coagulopathy, all of which may be secondary to the infection. Prevalence of cerebrovascular disease in HIV‐infected children is underestimated because of limited neuroimaging in low and middle income countries...
Source: Developmental Medicine and Child Neurology - February 18, 2016 Category: Child Development Authors: Charles K Hammond, Brian Eley, Nicky Wieselthaler, Alvin Ndondo, Jo M Wilmshurst Tags: Invited Review Source Type: research