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Predictive validity of developmental screening in young children with sickle cell disease: a longitudinal follow ‐up study
AimTo assess the predictive validity of developmental screenings in children with sickle cell disease (SCD) for academic outcomes and stroke risk. MethodParent questionnaires and medical record data were collected for a cohort receiving developmental screenings between September 2004 and May 2008 as toddlers or early school age. Screening outcomes were dichotomized (positive, negative) by a priori criteria. Questionnaires assessed school and social functioning, services received, and quality of life. Medical record data assessed general SCD morbidity and stroke risk. ResultsForty‐one toddlers (mean age 2y 5mo; 25 males, ...
Source: Developmental Medicine and Child Neurology - February 28, 2018 Category: Child Development Authors: Jeffrey Schatz, Alyssa M Schlenz, Kelsey E Smith, Carla W Roberts Tags: Original Article Source Type: research

Cerebrovascular disease in children with HIV‐1 infection
An estimated 3.2 million children worldwide have human immunodeficiency virus (HIV) infection. Antiretroviral therapy (ART) has resulted in prolonged survival, leading to an increase in complications previously recognized in adults. Children with HIV infection have increased risk of cerebrovascular disease from multiple aetiologies including HIV‐associated vasculopathy, opportunistic vasculitis, cardioembolism or coagulopathy, all of which may be secondary to the infection. Prevalence of cerebrovascular disease in HIV‐infected children is underestimated because of limited neuroimaging in low and middle income countries...
Source: Developmental Medicine and Child Neurology - February 18, 2016 Category: Child Development Authors: Charles K Hammond, Brian Eley, Nicky Wieselthaler, Alvin Ndondo, Jo M Wilmshurst Tags: Invited Review Source Type: research