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Mesenchymal stem cells in the treatment of ischemic stroke: progress and possibilities.
Authors: Doeppner TR, Hermann DM Abstract Stroke is a major cause of death and long-term disability in industrialized countries, and the only causal therapy for stroke comprises recombinant tissue plasminogen activator(rt-PA)-mediated recanalization of the occluded vessel. New experimental strategies focus on neuroregenerative approaches, among which the application of mesenchymal stem cells (MSCs) has gained increasing attention. MSCs, like other stem cells, have the capacity of unlimited self-renewal giving rise to differentiated cells from various cell lineages. Bone marrow (BM)-derived MSCs are the most frequen...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research

Meta-Analysis: The Clinical Application of Autologous Adult Stem Cells in the Treatment of Stroke
CONCLUSION: Most of the trials were early phase studies that focused on safety rather than efficacy. Stem cells have demonstrated breakthrough results in the field of regenerative medicine. Therefore, study design could be improved in the future by enrolling a larger patient population and focusing more on localized delivery rather than intravenous transplantation. Trials should also introduce a more standardized method of analyzing and reporting clinical outcomes to achieve a better comparable outcome and possibly recognize the full potential that these cells have to offer.PMID:35002259 | PMC:PMC8721025 | DOI:10.2147/SCCAA.S344943
Source: Stem Cells and Cloning: Advances and Applications - January 10, 2022 Category: Stem Cells Authors: Noora Hassani Sebastien Taurin Sfoug Alshammary Source Type: research

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