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Lacunar Infarcts, but Not Perivascular Spaces, Are Predictors of Cognitive Decline in Cerebral Small-Vessel Disease Clinical Sciences
Conclusions—Although a feature of small-vessel disease, PvS are not a predictor of cognitive decline, in contrast to lacunes. This study highlights the importance of carefully differentiating between lacunes and PvS in studies investigating vascular cognitive impairment.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Philip Benjamin, Sarah Trippier, Andrew J. Lawrence, Christian Lambert, Eva Zeestraten, Owen A. Williams, Bhavini Patel, Robin G. Morris, Thomas R. Barrick, Andrew D. MacKinnon, Hugh S. Markus Tags: Aging, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Association of Progression of Carotid Artery Wall Volume and Recurrent Transient Ischemic Attack or Stroke Clinical Sciences
Conclusions—The annual progression of carotid wall volume is independently associated with recurrent ischemic cerebrovascular events, and this measurement has added value for intraplaque hemorrhage and fibrous cap rupture in predicting future events.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Mingming Lu, Peng Peng, Yuanyuan Cui, Huiyu Qiao, Dongye Li, Jianming Cai, Xihai Zhao Tags: Clinical Studies, Magnetic Resonance Imaging (MRI), Atherosclerosis Original Contributions Source Type: research

Quantifying Infarct Growth and Secondary Injury Volumes Clinical Sciences
Conclusions—The contributions of IG and AD to lesion expansion can be measured separately over time through the use of image registration. This approach can be used to combine imaging outcome data from computed tomography and MRI.
Source: Stroke - June 25, 2018 Category: Neurology Authors: George W.J. Harston, Davide Carone, Fintan Sheerin, Mark Jenkinson, James Kennedy Tags: Imaging, Ischemic Stroke Original Contributions Source Type: research

Spinal epidural hematoma as a stroke mimic
Spinal epidural hematoma is a rare disease with an annual incidence of 1 per 1,000,000 individuals;1 however, it is a critical stroke mimic.2 As patients with spinal epidural hematoma typically present with acute hemiparesis,3,4 such a presentation is not expected to be detected by a computed tomography (CT) scan of the brain, which is the most common neuroimaging choice in patients with an activated stroke code. Indeed, there are several case reports in which patients with spinal epidural hematoma were misdiagnosed with ischemic stroke and treated with anti-thrombotic therapy, including intravenous thrombolysis,5 –10 oc...
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Yuichiro Inatomi, Makoto Nakajima, Toshiro Yonehara Source Type: research

Diagnostic and Prognostic Blood Biomarkers in Transient Ischemic Attack and Minor Ischemic Stroke: An Up-To-Date Narrative Review
Transient ischemic attack (TIA) is a brief episode of focal neurological deficit, lasting less than 24 hours, and reaching its climax usually within minutes. Patients with an even tiny ischemic brain lesion on imaging are considered, on tissue-based criteria, to have a minor ischemic stroke (MIS), usually with mild and non-disabling symptoms.1 Although a consensus clinical definition for MIS is currently lacking, 5 working definitions based on information from head computed tomography (CT) scan and clinical examination have been developed by the National Institute of Neurological Disorder and Stroke (NINDS) rt-PA stroke study Investigators.
Source: Journal of Stroke and Cerebrovascular Diseases - January 10, 2022 Category: Neurology Authors: Matteo Foschi, Marina Padroni, Samir Abu-Rumeileh, Ahmed Abdelhak, Michele Russo, Lucio D'Anna, Maria Guarino Tags: Review Article Source Type: research

Time to ct scan imaging after symptom onset among ischeamic stroke patients presenting to a quaternary hospital in ghana
This study sought to determine the time of onset of symptoms to the time a CT imaging was done among patients presenting with acute stroke at the Korle-Bu Teaching Hospital.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2023 Category: Neurology Authors: F. Duodu, D. Brodie Mends, B. Agbinko-Djobalar, P. Pekyi-Boateng, M. Amerwornu, P Adjei, A Akpalu, K Nkromah Source Type: research

The Effects of Alteplase 3 to 6 Hours After Stroke in the EPITHET-DEFUSE Combined Dataset: Post Hoc Case-Control Study Original Contributions
Conclusions— The data provide further evidence that alteplase significantly attenuates infarct growth and increases reperfusion compared with placebo in the 3- to 6- hour time window in patients selected based on MR penumbral imaging. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00238537
Source: Stroke - December 24, 2012 Category: Neurology Authors: Ogata, T., Christensen, S., Nagakane, Y., Ma, H., Campbell, B. C. V., Churilov, L., Lansberg, M. G., Straka, M., De Silva, D. A., Mlynash, M., Bammer, R., Olivot, J.-M., Desmond, P. M., Albers, G. W., Davis, S. M., Donnan, G. A., for the EPITHET and DEFUS Tags: CT and MRI, Other imaging, Thrombolysis Original Contributions Source Type: research

Functional connectivity magnetic resonance imaging in stroke: an evidence‐based clinical review
Stroke is a common condition that may lead to various degrees of neurological deficit and long‐term disability. It has become increasingly recognized that cortical reorganization of neuronal networks plays a significant role in regaining function following a focal brain injury. However, the mechanisms involved in this process are still not fully understood. Resting‐state functional connectivity magnetic resonance imaging is a rapidly evolving scanning technique that has the potential to shed light into this neuronal rearrangement. A better understanding of the underlying neurological pathways may contribute to the deve...
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Ourania Varsou, Mary Joan Macleod, Christian Schwarzbauer Tags: Review Source Type: research

Clinical Outcomes Strongly Associated With the Degree of Reperfusion Achieved in Target Mismatch Patients: Pooled Data from the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Studies Clinical Sciences
Conclusion— The degree of reperfusion documented on perfusion-weighted imaging after reperfusion therapies corresponds closely with clinical outcomes in TMM patients. Reperfusion of ≥90% of the perfusion lesion is an appropriate goal for reperfusion therapies to aspire to.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Inoue, M., Mlynash, M., Straka, M., Kemp, S., Jovin, T. G., Tipirneni, A., Hamilton, S. A., Marks, M. P., Bammer, R., Lansberg, M. G., Albers, G. W., for the DEFUSE 1 and 2 Investigators Tags: Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

'Risky' Stroke Prevention Procedure May Be Safe In Some Patients
A major study published in the Lancet Neurology, funded by the Medical Research Council (MRC) and the Stroke Association, has found that stenting in the carotid artery (in the neck) is as safe as carotid artery surgery at reducing stroke risk in some patients. The research, which was part of the International Carotid Stenting Study (ICSS), reveals that stenting is equally as safe as surgery in patients who show few signs of changes to brain tissue (known as white matter lesions) in a brain scan...
Source: Health News from Medical News Today - July 15, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Validating Imaging Biomarkers of Cerebral Edema in Patients With Severe Ischemic Stroke
Background: There is no validated neuroimaging marker for quantifying brain edema. We sought to test whether magnetic resonance imaging (MRI)–based metrics would reliably change during the early subacute period in a manner consistent with edema and whether they would correlate with relevant clinical endpoints.Methods: Serial MRI studies from patients in the Echoplanar Imaging Thrombolytic Evaluation Trial with initial diffusion-weighted imaging (DWI) lesion volume>82 cm3 were analyzed. Two independent readers outlined the hemisphere and lateral ventricle on the involved side and calculated respective volumes at baseline...
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2012 Category: Neurology Authors: Albert J. Yoo, Kevin N. Sheth, W. Taylor Kimberly, Zeshan A. Chaudhry, Jordan J. Elm, Sven Jacobson, Stephen M. Davis, Geoffrey A. Donnan, Gregory W. Albers, Barney J. Stern, R. Gilberto González Tags: Original Articles Source Type: research

The Essential Can Be Invisible to the Eyes: The “Fogging Effect” Phenomenon in the Subacute Stage of Ischemic Stroke
We report a patient who presented with a vanishing stroke on a follow-up brain computed tomography scan, a condition known as the “fogging effect” phenomenon.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2012 Category: Neurology Authors: Irapuá Ferreira Ricarte, José Luiz Pedroso, Flávio Augusto Carvalho, Agessandro Abrahão, Raul Alberto Valiente, Maramélia Miranda Alves, Daniela Laranja Gomes, Gisele Sampaio Silva Tags: Case Reports Source Type: research

Fluorescent Molecular Peroxidation Products: A Prognostic Biomarker of Early Neurologic Deterioration After Thrombolysis Clinical Sciences
Conclusions— FMPPs might be a valuable biomarker of poor early neurological outcome and be related to the appearance of symptomatic intracranial hemorrhage in tissue plasminogen activator–treated patients, one of the most feared neurological complications after thrombolytic treatment of acute ischemic stroke.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Llombart, V., Dominguez, C., Bustamante, A., Rodriguez-Sureda, V., Martin-Gallan, P., Vilches, A., Garcia-Berrocoso, T., Penalba, A., Hernandez-Guillamon, M., Rubiera, M., Ribo, M., Eschenfelder, C., Giralt, D., Molina, C. A., Alvarez-Sabin, J., Rosell, A Tags: Cerebrovascular disease/stroke, Acute Cerebral Infarction, Intracerebral Hemorrhage, Thrombolysis, Oxidant stress Clinical Sciences Source Type: research

Nascent Deep Microbleeds and Stroke Recurrences
This study investigated the contributions of nascent deep MBs to stroke recurrence.Methods: We prospectively analyzed nascent deep MBs in patients admitted to our hospital who were treated for index strokes between April 2004 and November 2009. The number of nascent deep MBs was counted on T2∗-weighted MRI scans around 1 year after the index strokes, and compared to previous MRIs on admission. Stroke recurrence–free rate curves were generated using the Kaplan–Meier method using the log-rank test. The odds ratio for nascent deep MBs was derived using a multivariate logistic regression model that was based on recurren...
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2013 Category: Neurology Authors: Toshio Imaizumi, Shigeru Inamura, Ikuhide Kohama, Kazuhisa Yoshifuji, Tatsufumi Nomura, Katsuya Komatsu Tags: Original Articles Source Type: research

Intravenous Thrombolysis Resulting In Acute Ischemic Stroke Recanalization Can Lead To Cerebral Hyperperfusion Syndrome (P7.123)
Conclusion- Cerebral hyperperfusion syndrome after intravenous thrombolysis in acute ischemic stroke should be suspected in patients that achieve arterial recanalization and develop unexplained new neuropsychiatric manifestations.Disclosure: Dr. Ong has nothing to disclose. Dr. Yeo has nothing to disclose. Dr. Ting has nothing to disclose. Dr. Sinha has nothing to disclose. Dr. Teoh has nothing to disclose. Dr. Chan has nothing to disclose. Dr. Seet has nothing to disclose. Dr. Sharma has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ong, J., Yeo, L., Ting, E., Sinha, A., Teoh, H. L., Chan, B., Seet, C. S., Sharma, V. Tags: Cerebrovascular Disease and Interventional Neurology: Issues in Acute Stroke Treatment Source Type: research