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Experimental Cardiac Radiation Exposure Induces Ventricular Diastolic Dysfunction with Preserved Ejection Fraction.
CONCLUSION: Experimental cardiac radiation exposure resulted in diastolic dysfunction without reduced EF. These data provide insight into the association between cardiac radiation exposure and HFpEF risk and lend further support for the importance of inflammation related coronary microvascular compromise in HFpEF. PMID: 28550173 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 26, 2017 Category: Physiology Authors: Saiki H, Moulay G, Guenzel AJ, Liu W, Decklever T, Classic K, Pham L, Chen HH, Burnett JC, Russell SJ, Redfield MM Tags: Am J Physiol Heart Circ Physiol Source Type: research

Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction
Breast cancer radiotherapy increases the risk of heart failure with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radioresistant, but radiation specifically affects coronary microvascular endothelial cells, with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF. Global cardiac expression of the sodium-iodide symporter (NIS) was induced by cardiotropic gene (adeno-associated virus serotype 9) delivery to 5-w...
Source: AJP: Heart and Circulatory Physiology - August 11, 2017 Category: Cardiology Authors: Saiki, H., Moulay, G., Guenzel, A. J., Liu, W., Decklever, T. D., Classic, K. L., Pham, L., Chen, H. H., Burnett, J. C., Russell, S. J., Redfield, M. M. Tags: RESEARCH ARTICLE Source Type: research