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Total 64 results found since Jan 2013.
Otitis Media Leads to Brain Abscess Presenting as Stroke
By Mikhail Elfond, DO; Esi Quayson, MD; & Joseph V.M. Kelly, MD, MBA
A 65-year-old man presented to the ED via EMS with symptoms of stroke. The paramedics stated his right-sided weakness and speech difficulty started 40 minutes prior to presentation in the ED. En route to the hospital, paramedics observed four episodes of facial twitching.
Vitals signs were significant for a rectal temperature of 100.2°F and a fingerstick blood sugar of 220 mg/dL. History of present illness was significant for a diagnosis of left otitis media treated with Augmentin and Vicodin at an urgent care center ...
Source: The Case Files - January 20, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Sneddon¿s syndrome: a comprehensive review of the literature
Sneddon?s syndrome (SS) is a rare non-inflammatory thrombotic vasculopathy characterized by the combination of cerebrovascular disease with livedo racemosa(LR).The Orpha number for SS is ORPHA820.It has been estimated that the incidence of SS is 4 per 1 million per annum in general population and generally occurs in women between the ages of 20 and 42?years. LR may precede the onset of stroke by years and the trunk and/or buttocks are involved in nearly all patients. The cerebrovascular manifestations are mostly secondary to ischemia (transient ischemic attacks and cerebral infarct). Other neurological symptoms range from ...
Source: Orphanet Journal of Rare Diseases - December 31, 2014 Category: Internal Medicine Authors: Shengjun WuZiqi XuHui Liang Source Type: research
Sneddon’s syndrome: a comprehensive review of the literature
Sneddon?s syndrome (SS) is a rare non-inflammatory thrombotic vasculopathy characterized by the combination of cerebrovascular disease with livedo racemosa(LR).The Orpha number for SS is ORPHA820.It has been estimated that the incidence of SS is 4 per 1 million per annum in general population and generally occurs in women between the ages of 20 and 42?years. LR may precede the onset of stroke by years and the trunk and/or buttocks are involved in nearly all patients. The cerebrovascular manifestations are mostly secondary to ischemia (transient ischemic attacks and cerebral infarct). Other neurological symptoms range from ...
Source: BioMed Central - December 31, 2014 Category: Journals (General) Authors: Shengjun WuZiqi XuHui Liang Source Type: research
Sneddon¿s syndrome: a comprehensive review of the literature
Sneddon’s syndrome (SS) is a rare non-inflammatory thrombotic vasculopathy characterized by the combination of cerebrovascular disease with livedo racemosa(LR). The Orpha number for SS is ORPHA820. It has been estimated that the incidence of SS is 4 per 1 million per annum in general population and generally occurs in women between the ages of 20 and 42 years. LR may precede the onset of stroke by years and the trunk and/or buttocks are involved in nearly all patients. The cerebrovascular manifestations are mostly secondary to ischemia (transient ischemic attacks and cerebral infarct). Other neurological symptoms range ...
Source: Orphanet Journal of Rare Diseases - December 31, 2014 Category: Internal Medicine Authors: Shengjun WuZiqi XuHui Liang Source Type: research
Talon noir: paring can eliminate the need for a biopsy
Introduction Talon noir (black heel or calcaneal petechiae) is a benign condition that appears as an asymmetric brown-black epidermal macule on the heel or elsewhere on the plantar foot. Punctate papillary dermal haemorrhages extend into the subcorneal space following shearing forces in an area of recurrent or sudden trauma.1 These lesions can mimic melanoma and haemorrhagic viral warts, especially in cases where there is no history of trauma. If the diagnosis of talon noir is considered, simple bedside tests can obviate the need for a biopsy to exclude malignant melanoma or unnecessary treatment for a presumed viral wart....
Source: Postgraduate Medical Journal - November 26, 2014 Category: Journals (General) Authors: Googe, A. B., Schulmeier, J. S., Jackson, A. R., Brodell, R. T. Tags: General practice / family medicine, Drugs: cardiovascular system, Pain (neurology), Stroke, Skin cancer, Screening (oncology), Radiology, Dermatology, Surgical diagnostic tests, General surgery, Epidemiology Images in medicine Source Type: research
Small nerve fiber pathology in critical illness documented by serial skin biopsies
Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness. © 2014 Wiley Periodicals, Inc.
Source: Muscle and Nerve - October 12, 2014 Category: Internal Medicine Authors: Miroslav Skorna, Roman Kopacik, Eva Vlckova, Blanka Adamova, Milena Kostalova, Josef Bednarik Tags: Research Article Source Type: research
Mystery Case: Cutaneous lesions in KRIT1-associated cerebral cavernous malformations
An asymptomatic 65-year-old man was seen because of a family history of cerebral cavernous malformations (CCM) and a positive test for the KRIT1/CCM1 (7q21.2) gene mutation. MRI of the brain showed multiple CCM (figure 1). The patient was noted to have innumerable skin lesions over the face, trunk, and limbs (figure 2). Cutaneous lesions occur in 9% of patients with familial CCM, particularly with KRIT1 mutations.1 These include red macules, nodular venous malformations, and hyperkeratotic cutaneous capillary-venous malformations.1 Skin biopsy shows collections of abnormal, dilated thin-walled blood vessels. Familial CCM s...
Source: Neurology - September 29, 2014 Category: Neurology Authors: Brownlee, W. J., Roxburgh, R. Tags: Other cerebrovascular disease/ Stroke, Other neurocutaneous disorders RESIDENT AND FELLOW SECTION Source Type: research
A Case Of Hemophagocytic Lymphohistiocytosis Syndrome In A Patient With Multiple Sclerosis On Fingolimod Therapy. (P2.206)
CONCLUSIONS:As far as we know, this syndrome has never been reported in fingolimod treated patients. EBV reactivation may have been the triggering factor of HLH in our patient. Whether fingolimod contributed to HLH, through a direct mechanism, or indirectly favoring EBV reactivation, remains unknown. Our case highlights the diagnostic challenge of HLH and the need of monitoring and reporting serious adverse events in patients exposed to new IMD. Study Supported by:Disclosure: Dr. Abreu has received personal compensation for activities with Bayer Pharmaceuticals Corporation, Novartis, and Biogen Idec. Dr. Peixoto has nothin...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Abreu, P., Peixoto, C., Carvalho, C., Santos, L., Sarmento, A., Jose Sa, M. Tags: MS and CNS Inflammatory Disease: Treatment Safety Source Type: research
Generalized Dilative Arteriopathy without Myopathy: A New Phenotype of Pompe Disease (P6.256)
Conclusion. This case demonstrates that LOPD may present as an isolated generalized dilative arteriopathy with repeated kidney and brain infarcts, and no myopathy. Pompe disease should be systematically screened in patients with generalized dilative arteriopathy.Disclosure: Dr. Echaniz-Laguna has received personal compensation for activities with Sanofi-Aventis Pharmaceuticals, Inc. Dr. Bataillard has nothing to disclose. Dr. Quenardelle has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Echaniz-Laguna, A., Bataillard, M., Quenardelle, V. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopthy (CADASIL) in Argentina (P2.123)
ConclusionsTo the best of our knowledge, this is the first cases series of patients with CADASIL in Argentina. Our findings are similar to those reported in the literature for other regions.Study Supported by:Disclosure: Dr. Hawkes has nothing to disclose. Dr. Wilken has nothing to disclose. Dr. Bruno has nothing to disclose. Dr. Pujol Lereis has nothing to disclose. Dr. Povedano has nothing to disclose. Dr. Taratuto has nothing to disclose. Dr. Taratuto has nothing to disclose. Dr. Ameriso has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Hawkes, M., Wilken, M., Bruno, V., Pujol Lereis, V., Povedano, G., Lubieniecki, F., Taratuto, A. L., Ameriso, S. Tags: Cerebrovascular Disease and Interventional Neurology: Behavioral, Cognitive, and Miscellaneous Source Type: research
Bilateral vertebral artery dissection, agenesis of both ICAs, and connective tissue aberrations
A 35-year-old woman presented with acute signs of stroke (appendix e-1 on the Neurology® Web site at www.neurology.org). After initial CT with angiography, MRI with time-of-flight angiography confirmed agenesis of both internal carotid arteries (ICA; figure 1A). It revealed bilateral vertebral artery (VA) dissections and ischemias in both middle artery territories (figure 1, A–E). Skin biopsy microscopy (figure 2) was consistent with ultrastructural connective tissue syndrome (uCTD), for which no further evidence was found apart from mild hypermobility of the finger joints. The underlying uCTD with structural ins...
Source: Neurology - April 8, 2013 Category: Neurology Authors: Lill, C. M., Gunther-Kunkel, K., Hoch, H., Paul, F., Grond-Ginsbach, C., Hausser, I., Zipp, F. Tags: Stroke in young adults, MRI, All Cerebrovascular disease/Stroke, Carotid artery dissection NEUROIMAGES Source Type: research
Stem Cells for Cell-Based Therapies
The world of stem cells
We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual:
Embryonic stem (ES) cells are also called totipotent cells.
The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc.
Each cell of early development is undifferentiated; that is, it is...
Source: ActionBioscience - December 28, 2012 Category: Science Authors: Ali Hochberg Source Type: news
Moderate systemic hypothermia decreases burn depth progression
Conclusions: Systemic hypothermia decreases burn depth progression in a rodent model and up-regulation of skin-protective genes and down-regulation of detrimental tissue remodeling genes by hypothermia may contribute to its beneficial effects.
Source: Burns : Journal of the International Society for Burn Injuries - November 13, 2012 Category: Cosmetic Surgery Authors: Julie A. Rizzo, Pamela Burgess, Richard J. Cartie, Balakrishna M. Prasad Tags: Articles Source Type: research
