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O68. Management of eclampsia and stroke during pregnancy
Conclusion These findings might aid the development of therapeutic strategies for pregnant women with eclampsia or stroke.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - August 31, 2015 Category: OBGYN Source Type: research

20 Defective placental bed vascular remodeling precedes manifestations of superimposed preeclampsia in stroke-prone spontaneously hypertensive rats
Conclusion Our data confirms the characterization of pregnant SHRSP as a model reproducing clinical diagnostic traits and the underlying placental pathology observed in preeclampsia superimposed on chronic hypertension. This novel model provides an attractive system for interventional studies and dissection of the multifactorial origins of hypertensive disorders of pregnancy.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 3, 2016 Category: OBGYN Source Type: research

O60. Treatment of hypertension in pregnancy
Conclusions According to recent guidelines, in the absence of randomised clinical trials recommendations how hypertension should be treated in pregnant women, can only be guided by experts’ opinion based on case reports and their meta-analyses.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - August 31, 2015 Category: OBGYN Source Type: research

KL 10 Animal models for gestational hypertension
Publication date: July 2017 Source:Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, Volume 9 Author(s): Christian Delles, Delyth Graham, Hannah L. Morgan, Heather Y. Small, Shona Ritchie The prevalence of cardiovascular diseases and particularly of hypertension is increasing worldwide. Consequently, the number of women with hypertension in pregnancy is also increasing. Several rodent models of hypertension have been characterised in depth but only few models exhibit the complex cardiovascular phenotype that is typically seen in human hypertension. The stroke-prone spontaneously hypertensi...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - August 13, 2017 Category: OBGYN Source Type: research

Assessment of total vascular resistance and total body water in normotensive women during the first trimester of pregnancy. A key for the prevention of preeclampsia
Conclusions High TVR during the first weeks of gestation may be an early marker of cardiovascular maladaptation more than the evaluation of water distribution and, in particular, with respect to the single blood pressure assessment. Moreover lower values of Inotropy Index could be an indicative of the worst cardiac performance.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - June 3, 2015 Category: OBGYN Source Type: research

O31. Magnesium homeostasis and gestational hypertension
Conclusion From a public health point of view, further studies on Mg homeostasis in pregnancy and intervention in terms of supplementation have a high priority, with the ultimate aim to develop prevention programs.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - August 31, 2015 Category: OBGYN Source Type: research

3 Is BP level achieved related to maternal and perinatal outcomes? A secondary analysis of bp values from the chips (control of hypertension in pregnancy study) randomised controlled trial
Conclusions Higher BP is a biomarker for adverse outcomes, even when target BP is low as in‘tight’ control. Although CHIPS showed that BP-lowering with antihypertensive therapy can reduce maternal risk (i.e., less severe hypertension), CHIPS did not show that perinatal risk is lowered (or increased). BP variability has a significant complex relationship with outcomes, possibly related to an adaptive response from the feto-placental unit. Our data suggest that when antihypertensive therapy is not achieving target BP values or BP is not stable, enhanced surveillance may be prudent.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 3, 2016 Category: OBGYN Source Type: research

27 The added value of the biomarkers sFlt-1, PlGF and their ratio on prediction of prolongation of pregnancy and maternal and fetal complications in (suspected) preeclampsia
Conclusions The biomarkers sFlt-1, PlGF and sFlt-1/PlGF ratio are strong predictors for maternal and fetal complications and pregnancy prolongation. Particularly the sFlt-1/PlGF ratio has much added value for the prediction of fetal complications and pregnancy prolongation.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 3, 2016 Category: OBGYN Source Type: research

Cerebral white matter lesions after pre-eclampsia
Conclusion Women who require 2 or more drugs to control blood pressure during pregnancy have an increased risk of developing cerebral white matter lesions after delivery.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 16, 2017 Category: OBGYN Source Type: research

Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study
Conclusion The CRADLE VSA, with integrated traffic light early warning system, can identify women who are hypertensive, at increased risk of severe pre-eclampsia complications and in need of escalation of care. Women who triggered a red light were at increased risk of kidney injury, magnesium sulfate use and CCU admission.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 16, 2017 Category: OBGYN Source Type: research

Maternal pre-eclampsia and long-term offspring health: Is there a shadow cast?
Publication date: April 2018 Source:Pregnancy Hypertension, Volume 12 Author(s): Sarah M. Goffin, José G.B. Derraik, Katie M. Groom, Wayne S. Cutfield Pre-eclampsia is a common pregnancy disorder with important short-term complications for mother and baby. Evidence suggests pre-eclampsia also has implications for the mother beyond pregnancy, as well as long-term effects on offspring health. Limited research has linked pre-eclampsia with changes in offspring blood pressure, BMI, and stroke risk. Underpinning mechanisms are poorly understood, but developmental programming may be involved. Research in this area has been hin...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 13, 2018 Category: OBGYN Source Type: research

Preeclampsia biomarkers: An assessment of maternal cardiometabolic health
Publication date: Available online 9 June 2018 Source:Pregnancy Hypertension Author(s): Genevieve Eastabrook, Tuba Aksoy, Samantha Bedell, Debbie Penava, Barbra de Vrijer Preeclampsia is a serious pregnancy condition defined as new-onset hypertension and proteinuria, commonly characterized as either early, ‘placental’, or late onset, ‘maternal’, using a cut-off of 34 weeks gestation. However, it may be more useful to differentiate between the vascular remodelling and placental invasion vs. inflammation and metabolic pathophysiology that underlie these forms of preeclampsia. Due to rising rates of obesity, the late...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - June 9, 2018 Category: OBGYN Source Type: research

Maternal pre-eclampsia and long-term offspring health: Is there a shadow cast?
Publication date: April 2018Source: Pregnancy Hypertension, Volume 12Author(s): Sarah M. Goffin, José G.B. Derraik, Katie M. Groom, Wayne S. CutfieldAbstractPre-eclampsia is a common pregnancy disorder with important short-term complications for mother and baby. Evidence suggests pre-eclampsia also has implications for the mother beyond pregnancy, as well as long-term effects on offspring health. Limited research has linked pre-eclampsia with changes in offspring blood pressure, BMI, and stroke risk. Underpinning mechanisms are poorly understood, but developmental programming may be involved. Research in this area has bee...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 5, 2018 Category: OBGYN Source Type: research

Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study
ConclusionThe CRADLE VSA, with integrated traffic light early warning system, can identify women who are hypertensive, at increased risk of severe pre-eclampsia complications and in need of escalation of care. Women who triggered a red light were at increased risk of kidney injury, magnesium sulfate use and CCU admission.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 5, 2018 Category: OBGYN Source Type: research

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