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Source: Acta Neurobiologiae Experimentalis
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Total 638 results found since Jan 2013.
Bone marrow stromal cells attenuate oxygen and glucose deprivation followed by re ‑oxygenation‑induced brain microvascular endothelial cell injury
Acta Neurobiol Exp (Wars). 2022;82(3):398-407. doi: 10.55782/ane-2022-038.ABSTRACTIschemic stroke is a severe threat to the health of older individuals. Bone marrow mesenchymal stem cells (BMSCs) have been implicated in ischemic stroke. Urokinase‑type plasminogen activator (uPA) and its specific receptor (uPAR) are associated with the pathological process of ischemic stroke. However, the relationship between BMSCs and uPA/uPAR in ischemic stroke remains unclear. For simulating the occurrence of an ischemic stroke in vitro, human cerebral microvascular endothelial cells (HBMECs) were subjected to oxygen and glucose depriv...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Cui-Ni Fang Tao Song Xi Tao Shu-Fen Liu Zhen Feng Source Type: research
HIF ‑1α protects PC12 cells from OGD/R‑induced cell injury by regulating autophagy flux through the miR‑20a‑5p/KIF5A axis
Acta Neurobiol Exp (Wars). 2022;82(3):358-372. doi: 10.55782/ane-2022-034.ABSTRACTHypoxia inducible factor 1α (HIF‑1α) has been reported to play a key role in protecting neurons from ischaemic injury. However, the exact molecular mechanisms remain largely unclear. PC12 cells were exposed to oxygen glucose deprivation/reoxygenation (OGD/R) conditions to mimic ischaemic injury in vitro. The expression of the HIF‑1α mRNA, miR‑20a‑5p, and kinesin family member 5A (KIF5A) mRNA was tested using qRT-PCR. Levels of the HIF‑1α, LC3I/II, P62, LAMP2, cathepsin B (CTSB) and KIF5A proteins were determined using western bl...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Jing-Wei Cao Zhan-Bin Tang Ji-He Song Jia-Lin Yao Xiao-Meng Sheng Zhi-Qiang Su Source Type: research
Effect of intranasal administration of caffeine on mPFC ischemia ‑induced cognitive impairment in BALB/c mice
Acta Neurobiol Exp (Wars). 2022;82(3):295-303. doi: 10.55782/ane-2022-028.ABSTRACTCaffeine is a psychoactive compound used widely to enhance cognitive functions in human or animal studies. The present study examined the effects of caffeine on cognitive performance and inflammatory factors in mice with medial prefrontal cortex (mPFC) ischemia. Mice underwent a photothrombotic mPFC ischemic stroke and were treated with normal saline or caffeine at different doses intranasally for 7 days. The sham surgery animals received normal saline intranasally. The Morris water maze test and social interaction test were performed to asse...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Fatemeh Farokhi-Sisakht Mehdi Farhoudi Javad Mahmoudi Fereshteh Farajdokht Rana Kahfi-Ghaneh Saeed Sadigh-Eteghad Source Type: research
Bone marrow stromal cells attenuate oxygen and glucose deprivation followed by re ‑oxygenation‑induced brain microvascular endothelial cell injury
Acta Neurobiol Exp (Wars). 2022;82(3):398-407. doi: 10.55782/ane-2022-038.ABSTRACTIschemic stroke is a severe threat to the health of older individuals. Bone marrow mesenchymal stem cells (BMSCs) have been implicated in ischemic stroke. Urokinase‑type plasminogen activator (uPA) and its specific receptor (uPAR) are associated with the pathological process of ischemic stroke. However, the relationship between BMSCs and uPA/uPAR in ischemic stroke remains unclear. For simulating the occurrence of an ischemic stroke in vitro, human cerebral microvascular endothelial cells (HBMECs) were subjected to oxygen and glucose depriv...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Cui-Ni Fang Tao Song Xi Tao Shu-Fen Liu Zhen Feng Source Type: research
HIF ‑1α protects PC12 cells from OGD/R‑induced cell injury by regulating autophagy flux through the miR‑20a‑5p/KIF5A axis
Acta Neurobiol Exp (Wars). 2022;82(3):358-372. doi: 10.55782/ane-2022-034.ABSTRACTHypoxia inducible factor 1α (HIF‑1α) has been reported to play a key role in protecting neurons from ischaemic injury. However, the exact molecular mechanisms remain largely unclear. PC12 cells were exposed to oxygen glucose deprivation/reoxygenation (OGD/R) conditions to mimic ischaemic injury in vitro. The expression of the HIF‑1α mRNA, miR‑20a‑5p, and kinesin family member 5A (KIF5A) mRNA was tested using qRT-PCR. Levels of the HIF‑1α, LC3I/II, P62, LAMP2, cathepsin B (CTSB) and KIF5A proteins were determined using western bl...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Jing-Wei Cao Zhan-Bin Tang Ji-He Song Jia-Lin Yao Xiao-Meng Sheng Zhi-Qiang Su Source Type: research
Effect of intranasal administration of caffeine on mPFC ischemia ‑induced cognitive impairment in BALB/c mice
Acta Neurobiol Exp (Wars). 2022;82(3):295-303. doi: 10.55782/ane-2022-028.ABSTRACTCaffeine is a psychoactive compound used widely to enhance cognitive functions in human or animal studies. The present study examined the effects of caffeine on cognitive performance and inflammatory factors in mice with medial prefrontal cortex (mPFC) ischemia. Mice underwent a photothrombotic mPFC ischemic stroke and were treated with normal saline or caffeine at different doses intranasally for 7 days. The sham surgery animals received normal saline intranasally. The Morris water maze test and social interaction test were performed to asse...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Fatemeh Farokhi-Sisakht Mehdi Farhoudi Javad Mahmoudi Fereshteh Farajdokht Rana Kahfi-Ghaneh Saeed Sadigh-Eteghad Source Type: research
Human albumin aggravates cerebral edema by disrupting the blood ‑brain barrier in a rat model of ischemic stroke
Acta Neurobiol Exp (Wars). 2022;82(3):284-294. doi: 10.55782/ane-2022-027.ABSTRACTCerebral edema and elevated intracranial pressure (ICP) are common complications observed following ischemic stroke. Osmotherapy has been used as a foundation to manage ICP induced by cerebral edema, and albumin is one of the most commonly used osmotic agents. The present study aimed to explore whether albumin lowered ICP by reducing cerebral edema when albumin elevated the colloid osmotic pressure (COP) of plasma. Sprague‑Dawley rats that underwent middle cerebral artery occlusion were used to assess COP and ICP. Magnetic resonance imaging...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Chunchang Li Shiying Zhang Xin Jiang Zhuo Li Yiqin Zhang Xusheng Li Hongguang Ding Hongke Zeng Source Type: research
Bone marrow stromal cells attenuate oxygen and glucose deprivation followed by re ‑oxygenation‑induced brain microvascular endothelial cell injury
Acta Neurobiol Exp (Wars). 2022;82(3):398-407. doi: 10.55782/ane-2022-038.ABSTRACTIschemic stroke is a severe threat to the health of older individuals. Bone marrow mesenchymal stem cells (BMSCs) have been implicated in ischemic stroke. Urokinase‑type plasminogen activator (uPA) and its specific receptor (uPAR) are associated with the pathological process of ischemic stroke. However, the relationship between BMSCs and uPA/uPAR in ischemic stroke remains unclear. For simulating the occurrence of an ischemic stroke in vitro, human cerebral microvascular endothelial cells (HBMECs) were subjected to oxygen and glucose depriv...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Cui-Ni Fang Tao Song Xi Tao Shu-Fen Liu Zhen Feng Source Type: research
HIF ‑1α protects PC12 cells from OGD/R‑induced cell injury by regulating autophagy flux through the miR‑20a‑5p/KIF5A axis
Acta Neurobiol Exp (Wars). 2022;82(3):358-372. doi: 10.55782/ane-2022-034.ABSTRACTHypoxia inducible factor 1α (HIF‑1α) has been reported to play a key role in protecting neurons from ischaemic injury. However, the exact molecular mechanisms remain largely unclear. PC12 cells were exposed to oxygen glucose deprivation/reoxygenation (OGD/R) conditions to mimic ischaemic injury in vitro. The expression of the HIF‑1α mRNA, miR‑20a‑5p, and kinesin family member 5A (KIF5A) mRNA was tested using qRT-PCR. Levels of the HIF‑1α, LC3I/II, P62, LAMP2, cathepsin B (CTSB) and KIF5A proteins were determined using western bl...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Jing-Wei Cao Zhan-Bin Tang Ji-He Song Jia-Lin Yao Xiao-Meng Sheng Zhi-Qiang Su Source Type: research
Effect of intranasal administration of caffeine on mPFC ischemia ‑induced cognitive impairment in BALB/c mice
Acta Neurobiol Exp (Wars). 2022;82(3):295-303. doi: 10.55782/ane-2022-028.ABSTRACTCaffeine is a psychoactive compound used widely to enhance cognitive functions in human or animal studies. The present study examined the effects of caffeine on cognitive performance and inflammatory factors in mice with medial prefrontal cortex (mPFC) ischemia. Mice underwent a photothrombotic mPFC ischemic stroke and were treated with normal saline or caffeine at different doses intranasally for 7 days. The sham surgery animals received normal saline intranasally. The Morris water maze test and social interaction test were performed to asse...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Fatemeh Farokhi-Sisakht Mehdi Farhoudi Javad Mahmoudi Fereshteh Farajdokht Rana Kahfi-Ghaneh Saeed Sadigh-Eteghad Source Type: research
Bone marrow stromal cells attenuate oxygen and glucose deprivation followed by re ‑oxygenation‑induced brain microvascular endothelial cell injury
Acta Neurobiol Exp (Wars). 2022;82(3):398-407. doi: 10.55782/ane-2022-038.ABSTRACTIschemic stroke is a severe threat to the health of older individuals. Bone marrow mesenchymal stem cells (BMSCs) have been implicated in ischemic stroke. Urokinase‑type plasminogen activator (uPA) and its specific receptor (uPAR) are associated with the pathological process of ischemic stroke. However, the relationship between BMSCs and uPA/uPAR in ischemic stroke remains unclear. For simulating the occurrence of an ischemic stroke in vitro, human cerebral microvascular endothelial cells (HBMECs) were subjected to oxygen and glucose depriv...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Cui-Ni Fang Tao Song Xi Tao Shu-Fen Liu Zhen Feng Source Type: research
Human albumin aggravates cerebral edema by disrupting the blood ‑brain barrier in a rat model of ischemic stroke
Acta Neurobiol Exp (Wars). 2022;82(3):284-294. doi: 10.55782/ane-2022-027.ABSTRACTCerebral edema and elevated intracranial pressure (ICP) are common complications observed following ischemic stroke. Osmotherapy has been used as a foundation to manage ICP induced by cerebral edema, and albumin is one of the most commonly used osmotic agents. The present study aimed to explore whether albumin lowered ICP by reducing cerebral edema when albumin elevated the colloid osmotic pressure (COP) of plasma. Sprague‑Dawley rats that underwent middle cerebral artery occlusion were used to assess COP and ICP. Magnetic resonance imaging...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Chunchang Li Shiying Zhang Xin Jiang Zhuo Li Yiqin Zhang Xusheng Li Hongguang Ding Hongke Zeng Source Type: research
HIF ‑1α protects PC12 cells from OGD/R‑induced cell injury by regulating autophagy flux through the miR‑20a‑5p/KIF5A axis
Acta Neurobiol Exp (Wars). 2022;82(3):358-372. doi: 10.55782/ane-2022-034.ABSTRACTHypoxia inducible factor 1α (HIF‑1α) has been reported to play a key role in protecting neurons from ischaemic injury. However, the exact molecular mechanisms remain largely unclear. PC12 cells were exposed to oxygen glucose deprivation/reoxygenation (OGD/R) conditions to mimic ischaemic injury in vitro. The expression of the HIF‑1α mRNA, miR‑20a‑5p, and kinesin family member 5A (KIF5A) mRNA was tested using qRT-PCR. Levels of the HIF‑1α, LC3I/II, P62, LAMP2, cathepsin B (CTSB) and KIF5A proteins were determined using western bl...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Jing-Wei Cao Zhan-Bin Tang Ji-He Song Jia-Lin Yao Xiao-Meng Sheng Zhi-Qiang Su Source Type: research
Effect of intranasal administration of caffeine on mPFC ischemia ‑induced cognitive impairment in BALB/c mice
Acta Neurobiol Exp (Wars). 2022;82(3):295-303. doi: 10.55782/ane-2022-028.ABSTRACTCaffeine is a psychoactive compound used widely to enhance cognitive functions in human or animal studies. The present study examined the effects of caffeine on cognitive performance and inflammatory factors in mice with medial prefrontal cortex (mPFC) ischemia. Mice underwent a photothrombotic mPFC ischemic stroke and were treated with normal saline or caffeine at different doses intranasally for 7 days. The sham surgery animals received normal saline intranasally. The Morris water maze test and social interaction test were performed to asse...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Fatemeh Farokhi-Sisakht Mehdi Farhoudi Javad Mahmoudi Fereshteh Farajdokht Rana Kahfi-Ghaneh Saeed Sadigh-Eteghad Source Type: research
Human albumin aggravates cerebral edema by disrupting the blood ‑brain barrier in a rat model of ischemic stroke
Acta Neurobiol Exp (Wars). 2022;82(3):284-294. doi: 10.55782/ane-2022-027.ABSTRACTCerebral edema and elevated intracranial pressure (ICP) are common complications observed following ischemic stroke. Osmotherapy has been used as a foundation to manage ICP induced by cerebral edema, and albumin is one of the most commonly used osmotic agents. The present study aimed to explore whether albumin lowered ICP by reducing cerebral edema when albumin elevated the colloid osmotic pressure (COP) of plasma. Sprague‑Dawley rats that underwent middle cerebral artery occlusion were used to assess COP and ICP. Magnetic resonance imaging...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Chunchang Li Shiying Zhang Xin Jiang Zhuo Li Yiqin Zhang Xusheng Li Hongguang Ding Hongke Zeng Source Type: research
