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Source: Brain and Development
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Total 35 results found since Jan 2013.
Improvement in a post-stroke pediatric patient with hemiplegia: Use of a hand-arm bimanual intensive therapy with hybrid assistive limb
We report a case of pediatric stroke in the chronic phase, in which a combination of novel treatments resulted in a significant improvement in physical function.
Source: Brain and Development - August 29, 2023 Category: Neurology Authors: Yoko Matsumoto, Yuji Yoshii, Akiyo Ikutomo, Mariko Yagi, Mio Nishimura, Yoko Kawasaki, Amanda Sarafian, Heakyung Kim, David P. Roye, Hiroko Matsumoto Tags: Case Report Source Type: research
MR vessel wall enhancement in a pediatric focal cerebral arteriopathy
We describe the case of a 7-year-old Japanese girl with right hemiplegia and dysarthria for 3 days. Brain MRI showed acute infarct in the left basal ganglia, and MRA and conventional cerebral angiogram detected vascular stenosis in the left distal internal carotid artery, left M1 and A1 segments.
Source: Brain and Development - February 17, 2023 Category: Neurology Authors: Shoko YOSHII, Rina FUKUI, Shinya HATTORI, Ryo YAMAGUCHI, Ryo FUJIMOTO, Hiromi AOYAMA, Taku OMATA Tags: Case Report Source Type: research
An exploratory study to identify neonatal arterial ischemic stroke: A single-center study
Neonatal arterial ischemic stroke (NAIS) presents as seizures, including convulsions, subtle seizures, and apnea, and most patients experience neurological sequelae. Diagnosis is often delayed owing to low test sensitivity. The present study aimed to identify the early clinical diagnostic factors for NAIS in neonates with seizures.
Source: Brain and Development - September 2, 2022 Category: Neurology Authors: Takashi Setoue, Shuichi Yatsuga, Kazutoshi Ito, Tatsuro Kodera, Yasuhiro Onda, Hiroyasu Kawano, Toshikazu Niimi, Tatsuki Miyamoto, Eiji Ohta, Shinichiro Nagamitsu Tags: Original article Source Type: research
Reply: Amnestic aphasia in MELAS can be epileptogenic
We thank Finsterer [1] for his interest of our article, “Thalamic aphasia associated with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes” [2].
Source: Brain and Development - July 7, 2022 Category: Neurology Authors: Yurie Sakata, Takuji Nakamura, Muneaki Matsuo Tags: Letter to the Editor Source Type: research
Amnestic aphasia in MELAS can be epileptogenic
Referring to the article by Sakata et al. we disagree with the diagnosis “thalamic aphasia” [1]. Since thalamic lesions can be associated with status epilepticus (SE) [2], it is crucial that SE has been ruled out2. Therefore, we should know if creatine-kinase (CK) was elevated to 5883 U/l due to myopathy, the stroke-like lesion (SLL), cardiomyopathy, or a SE. Becaus e periodic lateralised epileptiform discharges (PLEDs) can be the manifestation of a non-convulsive/minimal convulsive SE [3], we should know if a SE was recorded on electroencephalography (EEG) on hospital-day 8 and why midazolam was administered.
Source: Brain and Development - June 14, 2022 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
Thalamic aphasia associated with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes: A case report
Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with aphasia is a rare disorder, with the associated aphasia reported as either Wernicke ’s or Broca’s. Herein, we report a patient with MELAS complicated by thalamic aphasia.
Source: Brain and Development - May 10, 2022 Category: Neurology Authors: Yurie Sakata, Takuji Nakamura, Fumio Ichinose, Muneaki Matsuo Tags: Case Report Source Type: research
Subcortical infarction in a young adult with Hunter syndrome
Hunter syndrome (mucopolysaccharidosis type II, MPS II) is an X-linked lysosomal storage disease caused by deficiency of iduronate-2-sulfatase. Recently, stroke caused by embolization with Hunter syndrome has been reported. Here, we report the case of a 23-year-old Japanese man with Hunter syndrome who developed subcortical infarction by the mechanism similar to branch atheromatous disease (BAD).
Source: Brain and Development - February 3, 2022 Category: Neurology Authors: Motoya Kimura, Yoshiteru Azuma, Soutarou Taguchi, Mizuki Takagi, Hiromitsu Mori, Yasuto Shimomura, Jun-Ichi Niwa, Manabu Doyu, Akihisa Okumura Tags: Case Report Source Type: research
Reply to “Cortical cystic lesions – A typical endpoint of a stroke-like lesion”
We thank Drs. Finsterer and Zarrouk-Mahjoub for the letter written in response to our recently published article, “Linear cortical cystic lesions: Characteristic MR findings in MELAS patients” [1]. The reason we wrote the paper was that we noticed the high incidence of cortical cystic lesions (CCLs) in MELAS patients. Many of them were liner and limited within the cortex. On the other hand, CCLs have not be en observed in many cases with arterial infarction who don’t have mitochondrial disease. Generally speaking, cortical laminar necrosis is more common cortical MRI abnormalities of arterial infarction.
Source: Brain and Development - August 3, 2021 Category: Neurology Authors: Noriko Sato, Hidetoshi Ishigaki Tags: Reply Source Type: research
Combined medical therapy and neurosurgical revascularization preventing stroke in post-varicella angiopathy: Case report and review of literature
We report the first pediatric case with headache and PVA who was treated with surgical revascularization before the onset of ischemic events.
Source: Brain and Development - July 28, 2021 Category: Neurology Authors: Alessandro Iodice, Sara Signa, Mariasavina Severino, Domenico Tortora, Alice Zanetti, Giulia Amico, Gianluca Piatelli, Marta Bertamino, Marco Pavanello Tags: Case Report Source Type: research
Cortical cystic lesions – A typical endpoint of a stroke-like lesion
The interesting article by Ishigaki et al. about 71 patients with genetically confirmed mitochondrial disorders, of whom 21 presented with cortical cystic lesions (CCLs), and three with laminar cortical necrosis (LCN) [1], is appealing but raises concerns.
Source: Brain and Development - June 24, 2021 Category: Neurology Authors: Josef Finsterer, Sinda Zarrouk-Mahjoub Tags: Letter to the Editor Source Type: research
Linear cortical cystic lesions: Characteristic MR findings in MELAS patients
Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a progressive neurodegenerative disorder with stroke-like lesions. The common MRI findings are gyral swelling and high signal intensity on T2WI/FLAIR images crossing the vascular territories. We have observed a linear cystic lesion and a laminar necrosis in the affected cortices of MELAS patients. Herein, we evaluated these cortical MRI findings in each subtype of mitochondrial disease.
Source: Brain and Development - May 25, 2021 Category: Neurology Authors: Hidetoshi Ishigaki, Noriko Sato, Yukio Kimura, Eri Takeshita, Hirofumi Komaki, Emiko Chiba, Yoko Shigemoto, Yu-ichi Goto, Madoka Mori-Yoshimura, Masayuki Sasaki Tags: Original article Source Type: research
A rare infective cause of stroke in an immunocompetent child
Infections are a common cause of childhood stroke with variable presentation. The current case describes a rare infective cause of venous and arterial stroke in an immunocompetent girl with management implications.
Source: Brain and Development - August 23, 2020 Category: Neurology Authors: Juhi Gupta, Biswaroop Chakrabarty, Gagandeep Singh, Sonali Singh, Atin Kumar, Immaculata Xess, Prashant Jauhari, Sheffali Gulati Tags: Case Report Source Type: research
Fulminant cerebral venous thrombosis associated with the m.3243A > G MELAS mutation: A new guise for an old disease
We describe a novel presentation of MELAS-syndrome with severe cerebral venous thrombosis (CVT) and inflammation with a vasculopathy that affects the venous system as well.
Source: Brain and Development - July 21, 2019 Category: Neurology Authors: Marc Nikolaus, Anna Tietze, Leonille Schweizer, Angela M. Kaindl, Werner Stenzel, Markus Schuelke, Ellen Knierim Tags: Case Report Source Type: research
Transition from Leigh syndrome to MELAS syndrome in a patient with heteroplasmic MT-ND3 m.10158T > C
An m.10158T>C mutation in MT-ND3, encoding a subunit of respiratory complex I, causes early-onset Leigh syndrome (LS), mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS) syndrome, and LS and MELAS overlapping syndrome, presumably dependent on the ratio of heteroplasmy. Herein, we report a 4-year-old girl with heteroplasmic m.10158T>C mutation, showing an evolving age-dependent phenotype from LS to MELAS syndromes. She showed mild developmental delay during infancy, which was associated with magnetic resonance imaging lesions in the brain stem and basal ganglia.
Source: Brain and Development - June 5, 2019 Category: Neurology Authors: Atsuko Kori, Ikumi Hori, Tatsushi Tanaka, Kohei Aoyama, Koichi Ito, Ayako Hattori, Kyoko Ban, Yasushi Okazaki, Kei Murayama, Shinji Saitoh Tags: Case Report Source Type: research
Epileptic spasm and other forms of epilepsy in presumed perinatal arterial ischemic stroke in Turkey after more than 10 years follow-up: A single centre study
To identify the frequency of epilepsy and whether the association of epilepsy with clinical and neuroimaging findings in children with presumed perinatal arterial ischemic stroke (PPAIS).
Source: Brain and Development - April 15, 2019 Category: Neurology Authors: Gonca Bekta ş, Osman Kipoğlu, Edibe Pembegül Yıldız, Nur Aydınlı, Mine Çalışkan, Meral Özmen, Serra Sencer Tags: Original article Source Type: research
